488 research outputs found
Structure of the class C orphan GPCR GPR158 in complex with RGS7-Gβ5
No full textThe orphan GPR158 receptor belongs to the class C GPCR family and interacts with the regulator of G protein signaling 7 (RGS7)-Gβ5 complex. Here, the authors present the cryo-EM structure of human GPR158, which reveals that the extracellular domain contains a PAS domain, and they also determine the structures of GPR158 in complex with either one or two RGS7-Gβ5 heterodimers and discuss implications for the signaling mechanism
Structures of the GPR158-RGS7-Gb5 Complex: Fine-Tuning Mechanism of Signal Transduction
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Evolution of broadband network management system using an AOP
No full textIn broadband networks, dynamic service change affects the management system because of the variability in time to market, transmission quality and transport system. Therefore, reusability and maintainability become the important quality factors in Network Management System (NMS). An aspect-oriented software development method is a feasible solution for the evolvability of NMS. In this paper, we propose a method to generate aspects in a standard management information model using Aspect Conversion and Metric Calculation (ACMC) algorithm. We applied it ITU-T M.3100 and evaluated it via the ratio of reduced redundancy in point of crosscutting concerns
A microfluidic platform for a investigation on the effects of a physicochemical stimulation to the behaviors of cells
No full textClaudias Restoration of Hand-Stained History: The Bluest Eye and Blues
No full textThis paper explores how Blues resists the language of mass media in Toni Morrisons The Bluest Eye. Mass media reproduce and spread commodified images of white feminine beauty which is idealized from the viewpoint of white men. Encountering these images repeatedly, girls are socialized to imitate them and sexualized by men. Pecola, who is an ugly black girl in the novel, imagines that she can erase her black body and identifies with images of white girls. The more Pecola digests those images, the more her body loses corporeality and becomes abstract. Claudia, another black girl, however, thinks that by removing her bodily traits she loses her memory and history engraved in her skin. Pecola, who prays to transform into a pretty white girl, is not be able to see her black body and eventually goes mad. Mass media does not register Pecolas history and even the black community does not remember her. Her dead baby symbolizes the lifeless future of the black community where nothing is remembered and cherished. Having grown up, Claudia tries to remember and create meaning to Pecolas tragedy. For this, Claudia goes back to Blues her mother used to sing, which purifies the body from abstract images of mass media. In the end, Claudias Blues which is not separated from bodily experience, leaves mysophobic white culture hand-stained
Abstract 3289: Cutaneous melanocytic nevi and risk of melanoma deaths in women and men: a prospective study
No full textAbstract
Background: Increased number of common acquired melanocytic nevi (moles) has been associated with an increased risk of melanoma. It is unclear whether melanocytic nevi may predict melanoma deaths. We prospectively examined the association between number of melanocytic nevi and risk of melanoma deaths based on 77316 women from the Nurses’ Health Study (NHS) and 32454 men from the Health Professionals Follow-up Study (HPFS).
Methods: In both cohorts, diagnosis of melanoma was reported biennially and pathologically confirmed. Deaths were confirmed by next of kin or the National Death Index. Information on the number of moles with ≥3 mm diameter on the upper extremity was collected in 1986. We used Cox regression models to evaluate the associations between number of melanocytic nevi and risk of melanoma deaths in the overall cohorts as well as only among melanoma cases.
Results: A total of 2450 cases of melanoma were documented (1545 in NHS and 905 in HPFS), out of which we identified 192 incident deaths due to melanoma (87 in NHS and 105 in HPFS) during the follow-up (1986-2012). Increased number of melanocytic nevi was associated with melanoma deaths; the multivariate-adjusted hazard ratio (HR) for 3 or more melanocytic nevi compared with no nevi on the upper extremity was 2.55 (95% confidence interval (CI): 1.52-4.28) for women and 3.97 (95% CI: 2.54-6.22) for men. A secondary analysis further found that increased number of melanocytic nevi was associated with both lethal melanoma (melanoma cases that died of melanoma) and non-lethal melanoma. Among melanoma cases, increased number of melanocytic nevi was independently associated with risk of melanoma deaths in men, with a HR of 1.89 (95% CI: 1.17-3.05) for 3 or more melanocytic nevi. The association persisted even after adjusting for Breslow thickness of melanoma and appeared particularly stronger among those with lower Breslow thickness (P for interaction=0.03). However, number of melanocytic nevi was not significantly associated with risk of melanoma deaths among melanoma cases in women (HR=1.03, 95% CI: 0.61-1.76 for 3 or more nevi).
Conclusion: Increased number of melanocytic nevi was significantly associated with risk of melanoma deaths in our cohorts of women and men. A high number of melanocytic nevi may independently predict the risk of melanoma deaths among men with melanoma.
Citation Format: Wen-Qing Li, Hao Geng, Eunyoung Cho, Abrar Qureshi. Cutaneous melanocytic nevi and risk of melanoma deaths in women and men: a prospective study [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 3289. doi:10.1158/1538-7445.AM2017-3289</jats:p
Abstract 1917: AXL inhibition in ovarian cancer stem-like cells increases chemo-sensitivity
No full textAbstract
Cancer stem-like cells (CSCs), a small population of cancer cells with regenerative potential, may lead to the initiation and progression of secondary tumors. Long-term chemotherapeutic drug treatment can also result in the generation of a drug resistant population of cancer stem cells. In this study we have isolated CD44+ and CD117+ enriched ovarian cancer stem-like cells from primary cultured ascites cells removed from ascites fluid of naïve ovarian cancer patients. AXL, a type I receptor tyrosine kinase family member, is found to be over-expressed in ovarian cancer stem-like cells. Cell viability assays showed that ovarian CSCs are chemo-resistant to concentration dependent paclitaxel treatment. AXL was inhibited using a R428 and cell viability assays and apoptotic assays in the presence of paclitaxel were performed, which made the CSCs chemo sensitive. Si-RNA based inhibition of AXL also displayed a similar pattern of improving the sensitivity of the stem-like cells to the chemotherapeutic drug. PI3-kinase/Akt signaling pathway has also been shown to be involved in decreasing the cell viability during the inhibition of AXL. In conclusion, this study establishes the role of AXL, a receptor tyrosine kinase, as one of the key proteins influencing the chemo resistance in ovarian cancer stem-like cells.
Citation Format: Jin-Young Kim, Hyewon Chung, So-Jin Shin, Eunyoung Ha, Chi-Heum Cho. AXL inhibition in ovarian cancer stem-like cells increases chemo-sensitivity [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 1917. doi:10.1158/1538-7445.AM2017-1917</jats:p
New Product Development Utilizing Kimchi Lactobacillus and Adaptation to Manufacturing Process
No full text학위논문(석사) -- 서울대학교대학원 : 농업생명과학대학 푸드테크학과, 2023. 8. 이기원.In the global market, there has not been a beer brand that represents Korea. As K-Food is becoming more famous and being more acknowledged in the global market, there must be a K-beer since Food is always being paired with beer or wine in trendy food service industry. There are many well-known global beer brands in the global market already, so we need to develop a beer with distinct Korean characteristic to be differentiated from them.
Thus, we decided to utilize Kimchi Lactobacillus to develop sour beer recipe and produce this type of beer without any quality issues raised in the current production line.
Through this research, it is proved that Kimchi Lactobacillus can be used to brew sour beer and that mass production of Sour Beer is possible without any quality issues. It is now possible to launch K-Beer in the global market with distinctive Korean character.글로벌 시장에서 대한민국을 대표하는 맥주 브랜드는 아직 부재하다. K-Food가 나날이 발전하고 세계적으로 전파되고 있는 상황에서 더더욱 대한민국을 대표하는 맥주가 절실히 필요하다. 이미 세계적인 글로벌 맥주 브랜드들이 많기 때문에 대한민국 맥주의 차별성과 특별함을 나타내는 맥주가 필요하다고 판단되어 대한민국을 대표하는 식품인 김치로부터 유래한 유산균을 활용하여 Sour Beer를 개발하고 일반 공정에 품질영향 없이 적용하여 생산·공급해보고자 이 연구를 시작하였다.
이번 연구를 통해 공정적으로 어려운 Sour Beer의 대량 생산이 가능해짐을 확인하였고, Sour Beer에 일반적으로 사용되는 Lactobacillus가 아닌 대한민국 전통 음식인 김치 유산균으로도 Sour Beer 제조가 충분히 가능한 점을 확인하였다. 소비자들의 다양성에 대한 니즈에 맞는 제품 다변화가 기능해졌으며, 글로벌 시장에서 대한민국만의 차별점을 내세울 수 있는 맥주 출시가 기능해졌다.제 1 장 서 론 01
제 1 절 연구 배경 01
제 2 절 연구 목적 및 내용 01
제 2 장 이론적 배경 03
제 1 절 Sour Beer의 개념 및 정의 03
제 2 절 글로벌 Sour Beer 현황 04
제 3 절 국내 Sour Beer 현황 05
제 3 장 연구개발 내용 06
제 1 절 맥주 양조 공정 06
제 2 절 균주 선정 07
제 3 절 레시피 제작 12
제 4 절 이화학 분석 15
제 4 장 공정적용 18
제 1 절 파일럿 스케일 생산 18
제 2 절 제품 생산을 위한 행정 절차 18
제 5 장 결론 21
제 1 절 연구개발 성과 21
제 2 절 글로벌 시장 진출 계획 22
참고문헌 26
Abstract 27석
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