3,951 research outputs found
Natural and experimental infection of white spot syndrome virus (WSSV) in benthic larvae of mud crab Scylla serrata.
No full textMold allergen, pen C 13, induces IL-8 expression in human airway epithelial cells by activating protease-activated receptor 1 and 2.
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GIS-Based Cellular Automaton Model to allocate Kansas High Plains Irrigated Agriculture Land Use
No full texthttp://www.gis.ku.edu/gisday/2013/Platinum Sponsors
KU Institute for Policy & Social Research
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Bartlett & West
KU Department of Geography
KU Libraries
State of Kansas Data Access and Support Center (DASC)
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Kansas Biological Survey
KU Center for Global & International Studies
KU Environmental Studies Program
Bronze Sponsors
Global Information Systems
KU Center for Remote Sensing of Ice Sheets (CReSIS)
TREKK Design Group, LL
Characterization of cytokeratin 19-positive hepatocyte foci in the regenerating rat liver after 2-AAF/CCl4 injury.
No full textEffectiveness of Taiwanese traditional herbal diet for pain management in terminal cancer patients
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Natalia LL - artystka neoawangardowa
Full text linkThe paper shows Natalia Lach-Lachowicz (Natalia LL) as a neo avant-garde artist whose works in a specific maximalistic way are very close to the main currents of avant-garde trends: new mediality (photography), minimalism, conceptualism, performance, bodyart, pop-art, and feminist art. The author of the article concentrates mainly on the mutual influences of conceptualism, consumptionism, and feminism in Natalia LL’s works and pays attention to the emancipatory potential of her works of the seventies and the eighties
Energy flux in isotropic turbulence under large variations of external forcing
No full textWe investigate the response of energy flux in isotropic turbulence to step-function like perturbation in external forcing at large length scales. From both physical experiments and direct numerical simulations, we measured the evolution of the Eulerian velocity structure functions, such as , , before and after the perturbation in forcing. In both cases, we observed the cascade of the energy excess at large scales cascade through scales to the dissipative range, which can be used to study the dynamics of the cascade, and in particular, to estimate the relevant time scales
Vitamin D and innate immunity in pneumonia and COPD
No full textA resurgence of interest in vitamin D research has led to the discovery that it plays a role in an unexpectedly large number of biological processes, and that reduced levels of this hormone are implicated in a range of diseases. In fact, it is estimated that vitamin D is involved in the regulation of 3% of the human genome. Two genes containing the target sequence indicative of vitamin D regulation are those encoding LL-37 and hBD-2. These antimicrobial peptides are integral components of the innate immune system and act as natural antibiotics to help combat infection.
The respiratory epithelium exposes a large surface area to environmental pathogens, making the innate immune response extremely important in its defence. Microbial infection of the respiratory tract is the cause of pneumonia, and is implicated in cases of COPD exacerbation. This study aimed to determine whether a relationship existed between vitamin D, LL-37 and hBD-2 in 185 patients admitted to Waikato hospital with either condition. It was hypothesised that low vitamin D would correlate with reduced peptide levels, and that this would be associated with increased infection severity and higher mortality rates.
Peptide concentrations in patient plasma were measured by indirect ELISA and compared to 25D levels. Statistical analysis revealed no significant associations between vitamin D status, peptide levels and severity, but did show increased mortality in individuals with severe vitamin D deficiency or low LL-37.
Based on the significance of LL-37 as a predictor of mortality (particularly in COPD), development of a plasma screening method using MALDI-TOF mass spectrometry was attempted, as a potential means of identifying patients most at risk. The success of this method was limited however, as the low abundance and small size of the mature peptide caused detection problems.
A protocol for assessing the vitamin D binding protein (DBP) genotype was developed, as it influences baseline 25D levels and response to supplementation. The association between low vitamin D and mortality suggests that supplementation could improve survival rates and, as the supplement dose required for effectiveness is genotype-dependent, this method could allow determination of the appropriate amount to administer to at-risk individuals
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