3,651 research outputs found
CompB (J-113397), selectively and competitively antagonizes nociceptin activation of inwardly rectifying K(+) channels in rat periaqueductal gray slices.
No full text[Nphe(1)]N/OFQ-(1-13)-NH(2) is a competitive and selective antagonist at nociceptin/orphanin FQ receptors mediating K(+) channel activation in rat periaqueductal gray slices
No full text
[Nphe(1)]N/OFQ-(1-13)-NH(2) is a competitive and selective antagonist at nociceptin/orphanin FQ receptors mediating K(+) channel activation in rat periaqueductal gray slices.
No full textPharmacological characterization of nociceptin/orphanin FQ receptors, a novel opioid receptor family, in the midbrain periaqueductal gray.
No full textProteomic identification of biomarkers related to Helicobacter pylori-associated gastroduodenal disease: challenges and opportunities.
No full text[Nphe(1)]N/OFQ-(1-13)-NH2 is a competitive and selective antagonist at nociceptin/orphanin FQ receptors mediating K+ channel activation in rat periaqueductal gray slices
No full textA novel member of the opioid related receptor family, the nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor was identified
and demonstrated to be involved in many physiological functions including pain regulation. [Nphe1]N/OFQ-(1-13)-NH2 (Nphe) is a
novel peptide antagonist of NOP receptors, developed using peripheral preparations. We have quantitatively investigated the interaction
of Nphe with N/OFQ, the endogenous ligand of NOP receptors, in the midbrain ventrolateral periaqueductal gray (PAG), a crucial brain
region for N/OFQ-induced reversal of opioid analgesia, using the patch-clamp recording technique in brain slices. N/OFQ concentrationdependently
activated an inwardly rectifying K+ current in response to hyperpolarization ramps from 60 to 140 mV. Nphe concentration-
dependently attenuated the K+ current activated by N/OFQ without changing its reversal potential. The presence of Nphe rightshifted
the concentration-response curve to N/OFQ in a parallel manner. The Schild plot analysis yielded a slope of 1.16 and a pA2
value of 6.64 that is similar to those obtained in peripheral preparations. At concentrations up to 3 μM, Nphe affected neither the
membrane current per se, nor the inwardly rectifying K+ current activated by [D-Ala2, N-Me-Phe4,Gly-ol5]-enkephalin or baclofen, a
mu-opioid and GABAB receptor agonist, respectively. It is concluded that Nphe acts as a pure, selective and competitive antagonist at
native NOP receptors of ventrolateral PAG neurons
Semiparametric Regression Analysis of Panel Count Data: A Practical Review
Full text linkPeer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/149207/1/insr12271_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/149207/2/insr12271.pd
Up-regulation of Inhibitory Natural Killer Receptors CD94/NKG2A with Suppressed Intracellular Perforin Expression of Tumor-Infiltrating CD8+ T Lymphocytes in Human Cervical Carcinoma.
No full text- …
