63 research outputs found
The role of blockchain as a security mechanism for electronic health records
No full textBlockchain technology provides a new way of decentralizing existing systems through its components. The application of blockchain in healthcare has the potential to revamp the existing centralized healthcare information systems. The electronic healthcare records (EHRs) are computerized format of medical records that include the collection of patient data which play a key role in the healthcare information systems. As the healthcare data is constantly shared among different untrusted parties, security of the EHRs is of prime importance, and blockchain provides a way to decentralize and secure the EHR systems. In this light, this thesis studies the role of blockchain as a security mechanism in the management of EHRs through the method of a literature survey. A classification method has been developed using existing works, to classify the literature, and analyse it according to the layered architecture of blockchain and the CIA triad. Through the survey, it is seen that the blockchain technology is a potential security solution for the decentralized management of EHRs, through its components- the consensus mechanism, Merkle tree structures, and public key cryptography. Further, it serves more as an added layer of security to the EHRs, rather than a direct mechanism, because the EHRs are not directly stored on the blockchain. The possible future research direction in this regard, is found in studying in detail the suitable consensus mechanisms for application in EHRs systems, and an evaluation of the technology in a real-world application.
The role of blockchain as a security mechanism for electronic health records
No full textBlockchain technology provides a new way of decentralizing existing systems through its components. The application of blockchain in healthcare has the potential to revamp the existing centralized healthcare information systems. The electronic healthcare records (EHRs) are computerized format of medical records that include the collection of patient data which play a key role in the healthcare information systems. As the healthcare data is constantly shared among different untrusted parties, security of the EHRs is of prime importance, and blockchain provides a way to decentralize and secure the EHR systems. In this light, this thesis studies the role of blockchain as a security mechanism in the management of EHRs through the method of a literature survey. A classification method has been developed using existing works, to classify the literature, and analyse it according to the layered architecture of blockchain and the CIA triad. Through the survey, it is seen that the blockchain technology is a potential security solution for the decentralized management of EHRs, through its components- the consensus mechanism, Merkle tree structures, and public key cryptography. Further, it serves more as an added layer of security to the EHRs, rather than a direct mechanism, because the EHRs are not directly stored on the blockchain. The possible future research direction in this regard, is found in studying in detail the suitable consensus mechanisms for application in EHRs systems, and an evaluation of the technology in a real-world application.
Blockchains’ Impact on Enhancing Physical Activity, Rehabilitation, Sport, and Exercise-Based Therapeutics : A Systematic Review
No full textBlockchain technology is increasingly recognized as a promising solution for managing health-related data, particularly in promoting well-being through physical activity. This is becoming more significant as the Internet of Things (IoT) and sport monitoring sensors continue to expand and become more available, leading to a growing number of users in sports and prolonged usage of these devices, which continuously capture large volumes of physical activity data. The substantial volume of data generated in sports and physical activities, combined with distinct concerns compared to medical and health-related information, makes this domain a unique case for blockchain applications. This paper presents a systematic review of blockchain applications in physical activity, exercise-based rehabilitation, fitness, sport, and exercise-based therapeutics (PARFSET). It specifically focuses on examining their quality attributes, including privacy, security, accountability, personalization, adherence, and extensibility. Our objective is to establish a foundational understanding of the benefits of a blockchain in PARFSET domains, particularly following the decline in initial hype for blockchain technology. We aim to provide a clearer perspective on potential applications, future advancements, and research directions. To this end, we assess the maturity levels of blockchain adoption in these areas and highlight specific examples where a blockchain contributes to enhanced data protection, user-centered customization, trust through accountability, and system scalability. Additionally, we present a hypothetical illustrative case to demonstrate how blockchain applications and their quality outcomes can be effectively integrated. Finally, the paper explores the challenges associated with blockchain implementation and outlines potential directions for future research
Analysis of Production, Impact, and Scientific Collaboration on Difficult Airway Through the Web of Science and Scopus (1981–2013)
No full textBackground: Bibliometrics, the statistical analysis of written publications, is an increasingly popular approach to the assessment of scientific activity. Bibliometrics allows researchers to assess the impact of a field, or research area, and has been used to make decisions regarding research funding. Through bibliometric analysis, we hypothesized that a bibliometric analysis of difficult airway research would demonstrate a growth in authors and articles over time.
Methods: Using the Web of Science (WoS) and Scopus databases, we conducted a search of published manuscripts on the difficult airway from January 1981 to December 2013. After removal of duplicates, we identified 2412 articles. We then analyzed the articles as a group to assess indicators of productivity, collaboration, and impact over this time period.
Results: We found an increase in productivity over the study period, with 37 manuscripts published between 1981 and 1990, and 1268 between 2001 and 2010 (P 9% for both WoS and Scopus, and CAGR for anesthesiology as a whole =0.64% in WoS, and =3.30% in Scopus. Furthermore, we found a positive correlation between the number of papers published per author and the number of coauthored manuscripts (P < .001). We also found an increase in the number of coauthored manuscripts, in international cooperation between institutions, and in the number of citations for each manuscript. For any author, we also identified a positive relationship between the number of citations per manuscript and the number of papers published (P < .001).
Conclusions: We found a greater increase over time in the number of difficult airway manuscripts than for anesthesiology research overall. We found that collaboration between authors increases their impact, and that an increase in collaboration increases citation rates. Publishing in English and in certain journals, and collaborating with certain authors and institutions, increases the visibility of manuscripts published on this subject.Depto. de MedicinaFac. de MedicinaTRUEpu
2008 Author Recognition Bibliography
No full texthttps://scholarworks.gvsu.edu/authorrecognition/1006/thumbnail.jp
The helix-loop-helix transcriptional regulator Id4 is required for terminal differentiation of luminal epithelial cells in the prostate
No full textInhibitor of differentiation 4 (Id4), a member of the helix-loop-helix family of transcriptional regulators has emerged as a tumor suppressor in prostate cancer. In this study we investigated the effect of loss of Id4 (Id4-/-) on mouse prostate development. Histological analysis was performed on prostates from 25 days, 3 months and 6 months old Id4-/- mice. Expression of Amacr, Ck8, Ck18, Fkbp51, Fkbp52, androgen receptor, Pten, sca-1 and Nkx3.1 was investigated by immunohistochemistry. Results were compared to the prostates from Nkx3.1-/-mice. Id4-/- mice had smaller prostates with fewer and smaller tubules. Subtle PIN like lesions were observed at 6mo. Decreased Nkx3.1 and Pten and increased stem cell marker sca-1, PIN marker Amacr and basal cell marker p63 was observed at all ages. Persistent Ck8 and Ck18 expression suggested that loss of Id4 results in epithelial commitment but not terminal differentiation in spite of active Ar. Loss of Id4 attenuates normal prostate development and promotes hyperplasia/ dysplasia with PIN like lesions. The results suggest that loss of Id4 maintains stem cell phenotype of �luminal committed basal cells�, identifying a unique prostate developmental pathway regulated by Id4
TYPIFICATION OF TECTARIA PARADOXA (POLYPODIACEAE SUB-FAM. TECTARIOIDEAE)
No full textMAZUMDAR, J. 2017. Typification of Tectaria paradoxa (Polypodiaceae subfam. Tectarioideae). Reinwardtia 16(2): 93?95. — Aspidium paradoxum has not yet been lectotypified, because the original material is ambiguous. A specimen from the collections of A. Fée, the author of the species, was located in the herbarium of Montpellier (MPU), which is here designated as the lectotype for this species. It is now known as Tectaria paradoxa, a fern species widely distributed across tropical Asia.</jats:p
-174G/C Polymorphism in the Interleukin-6 Promoter Is Differently Associated with Prostate Cancer Incidence Depending on Race
No full textInterleukin-6 (IL-6), a pro-inflammatory cytokine, is involved in prostate cancer progression, including androgen independence. Serum IL-6 levels also correlate with prostate tumor burden, prostate-specific antigen levels and metastasis. Since circulating cytokine levels vary considerably inter-individually, such variation could be linked to genetic factors, including genetic polymorphism. The -174G>C/rs1800795 polymorphism in the IL-6 promoter is functionally relevant in terms of transcriptional regulation and disease association. We investigated a possible association of the -174G/C polymorphism with prostate cancer. Since significant racial disparities exist in prostate cancer incidence, we also investigated this association between the -174G/C polymorphism and prostate cancer in Caucasians and African-Americans, separately. Direct sequencing of the PCR amplicon from genomic DNA was used for genotyping rs1800795 in all subjects [age-matched controls (N = 140) and prostate cancer patients (N = 164)]. Sample size and power was calculated using the PGA software. We found the GG genotype to be associated with increased risk of prostate cancer in Caucasian subjects, whereas the CC genotype was associated with increased risk in the African-American sample set. Such a dimorphic genotypic association with cancer and race is unique and suggests a complex gene-gene and gene-environment interaction
A Modified Coupled Spectrophotometric Method to Detect 2-5 Oligoadenylate Synthetase Activity in Prostate Cell Lines
No full textBackground: 2-5 oligoadenylate synthetases (OAS) are interferon inducible enzymes that polymerizes ATP to 2-5-linked oligomers of adenylate (2-5As). As part of the innate immune response, these enzymes are activated by viral double stranded RNA or mRNAs with significant double stranded structure. The 2-5As in turn activate RNaseL that degrade single stranded RNAs. Three distinct forms of OAS exist in human cells (OAS1, 2 and 3) with each form having multiple spliced variants. The OAS enzymes and their spliced variants have different enzyme activities. OAS enzymes also play a significant role in regulating multiple cellular processes such as proliferation and apoptosis. Moreover, Single nucleotide polymorphisms that alter OAS activity are also associated with viral infection, diabetes and cancer. Thus detection of OAS enzyme activity with a simple spectrophotometric method in cells will be important in clinical research
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