567 research outputs found
Correction：Roles of FoxP3-positive Regulatory T Cells in Lymphoid Follicle Formation Associated with Lung Squamous Cell Carcinoma
No full textCorrection to：Roles of FoxP3-positive Regulatory T Cells in Lymphoid Follicle Formation Associated with Lung Squamous Cell Carcinoma
Morimichi Nishihira, Nakazato Yoshimasa, Ikuma Wakamatsu, Sumiko Maeda, Takashi Inoue, Osamu Araki,
Yoko Karube, and Masayuki Chida
Correction to：Dokkyo Journal of Medical Sciences 47（1）：9-13, 2020.
In the original publication of the article, Figure 1 were published incorrectly. The corrected Figure 1 is given in this Correction.journal articl
S-Nitrosylation in Organs of Mice Exposed to Low or High Doses of γ-Rays: The Modulating Effect of Iodine Contrast Agent at a Low Radiation Dose
No full textThe covalent addition of nitric oxide (NO•) onto cysteine thiols, or S-nitrosylation, modulates the activity of key signaling proteins. The dysregulation of normal S-nitrosylation contributes to degenerative conditions and to cancer. To gain insight into the biochemical changes induced by low-dose ionizing radiation, we determined global S-nitrosylation by the “biotin switch” assay coupled with mass spectrometry analyses in organs of C57BL/6J mice exposed to acute 0.1 Gy of cesium-137 γ-rays. The dose of radiation was delivered to the whole body in the presence or absence of iopamidol, an iodinated contrast agent used during radiological examinations. To investigate whether similar or distinct nitrosylation patterns are induced following high-dose irradiation, mice were exposed in parallel to acute 4 Gy of cesium-137 γ rays. Analysis of modulated S-nitrosothiols (SNO-proteins) in freshly-harvested organs of animals sacrificed 13 days after irradiation revealed radiation dose- and contrast agent-dependent changes. The major results were as follows: (i) iopamidol alone had significant effects on S-nitrosylation in brain, lung and liver; (ii) relative to the control, exposure to 0.1 Gy without iopamidol resulted in statistically-significant SNO changes in proteins that differ in molecular weight in liver, lung, brain and blood plasma; (iii) iopamidol enhanced the decrease in S-nitrosylation induced by 0.1 Gy in brain; (iv) whereas a decrease in S-nitrosylation occurred at 0.1 Gy for proteins of ~50 kDa in brain and for proteins of ~37 kDa in liver, an increase was detected at 4 Gy in both organs; (v) mass spectrometry analyses of nitrosylated proteins in brain revealed differential modulation of SNO proteins (e.g., sodium/potassium-transporting ATPase subunit beta-1; beta tubulins; ADP-ribosylation factor 5) by low- and high-dose irradiation; and (vi) ingenuity pathway analysis identified major signaling networks to be modulated, in particular the neuronal nitric oxide synthase signaling pathway was differentially modulated by low- and high-dose γ-irradiation.Peer reviewe
Measurement of stress and strain development around a pile in a photoelastic granular material
No full textThis paper presents the results of model pile penetration in a photoelastic material. The soil in this test is represented by an assembly of photoelastically sensitive glass particles. This allows for the determination of stresses in the assembly by the photoelastic method. Displacements around the pile are measured using digital image correlation. Tests were performed in a medium dense particle assembly. The development of stresses and strains, in particular the development of horizontal stress, around the pile tip and pile shaft is quantified and presented in this paper.Geo-engineerin
Hierarchical neural network model of the visual system determining figure/ground relation
No full textCXCL10-CXCR3 enhances the development of neutrophil-mediated fulminant lung injury of viral and nonviral origin
No full textCXCL10-CXCR3 Enhances the Development of Neutrophil-mediated Fulminant Lung Injury of Viral and Nonviral Origi
Massively parallel solver for the high-order Galerkin Least-Squares method
No full textThesis (S.M.)--Massachusetts Institute of Technology, Computation for Design and Optimization Program, 2009.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Cataloged from student submitted PDF version of thesis.Includes bibliographical references (p. 85-91).A high-order Galerkin Least-Squares (GLS) finite element discretization is combined with massively parallel implicit solvers. The stabilization parameter of the GLS discretization is modified to improve the resolution characteristics and the condition number for the high-order interpolation. The Balancing Domain Decomposition by Constraints (BDDC) algorithm is applied to the linear systems arising from the two-dimensional, high-order discretization of the Poisson equation, the advection-diffusion equation, and the Euler equation. The Robin-Robin interface condition is extended to the Euler equation using the entropy-symmetrized variables. The BDDC method maintains scalability for the high-order discretization for the diffusion-dominated flows. The Robin-Robin interface condition improves the performance of the method significantly for the advection-diffusion equation and the Euler equation. The BDDC method based on the inexact local solvers with incomplete factorization maintains the scalability of the exact counterpart with a proper reordering.by Masayuki Yano.S.M
Red emission phosphor for real‐time skin dosimeter for fluoroscopy and interventional radiology
No full textChanges in the light condition and the density of regenerating Chamaecyparis obtusa individuals after selection cutting practice at the Akasawa Experimental Forest, Kiso, Nagano Prefecture.
No full textThis data provide the location and topographic wetness index of each quadrat, the changes in the light conditions and the densities of Chamaecyparis obtusa individuals after selection cutting practice, and small seedling (HThe long-term experimental research for
ca. 30 years was accomplished by the cooperation and collaboration among many
researchers and investigation staffs including the author, Mr. Kuniyuki Arai,
Mr. Tetsuya Sengoku, Dr. Takeshi Morisawa, Mr. Haruhiko Mimura, Mr. Naoaki
Tate, Mr. Masayuki Imamura, and Mr. Hiromichi Kushima.</div
The Idea of Non-verbal Rule in Early Warring States Thought and Its Incorporation into the Concept of Cheng
No full text本文旨在釐清中國古代政治哲學中的「非語言」因素及其在統治學?之功能和意義。為進?此一工作，筆者具體?證中國古代思想家為何懷疑語言統治之功效，並探究他們試圖以何種方式取代語言的統治效能。在郭店楚簡和上博楚簡的文獻中，對只靠語言法?統治人民之嫌?廣泛可?。並且，?考察郭店《?子》中的「非語言統治」相關?述，我們並未發現「儒」「道」相對?的思想框架。據此本文指出：在郭店楚簡和上博楚簡思想形成的戰國早期，「非語言統治」之政治思想應該是?分學派的普遍觀點。本文也將分析此種「非語言統治」的概?和主張逐步被「誠」概?涵攝的?況。戰國中後期以後的文獻，開始使用「誠」概?以提出?完整的「非語言統治」?述。In the course of development of political thought during the Warring States Period and Qin-Han Empires, our general impression is that aristocratic court decorum was replaced by positive law. On the other hand, however, disbelief in verbal order by rulers has been expressed in various Warring States political discourses. Indeed, a group of thinkers believed that the establishment of a high level of morality would enable rulers to establish authority over the people without the help of any verbal decree. Interestingly, such ideas often appear in the newly excavated Guodian Bamboo texts. From this viewpoint, the paper will explicate several concepts and arguments that support the idea of such “non-verbal rule” mainly in the Guodian texts, and trace the process by which these ideas are crystallized into the idea of cheng (sincerity/co-creativity) in the mid-late Warring States and Qin-Han texts. In doing so, the author hopes that this research can delineate the process of theorization of main conceptual terms which were essential for the discussion of socio-political issues arising in Warring States political discourse
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