1,721,132 research outputs found

    ICT for all: Where do we stand?

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    Although its importance is undeniable, designing in a more inclusive way is not yet fully adopted in the field of design and planning, whose reference continues to be the standard man. An approach which not only excludes people with disabilities, but also other categories that diverge from the physical and cognitive characteristics of the standard human model, such as women, the elderly, and children. This problem affects different contexts and can be observed especially in the area of Information and Communication Technologies (ICTs), which are often designed without taking into account the peculiarities that distinguish these categories of users. Referring to the categories affected by the digital divide, the article reflects on the need to promote specific methodologies, such as Universal Design and User-centered Design, so that attitudinal and psychological issues related to different categories of users are considered

    Evolution of the Human chromosome 7: new information from the mapping of William-Breuren locus on non human primates chromosomes.

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    Human chromosome 7 (HSA7) derives, by a pericentric inversion and a paracentric inversion, from an ancestral chromosome homologous to chromosome 10 of Pongo pygmaeus (the Asiatic Orang-Utan). Nevertheless the genesis of this autosome during primates evolution is not clear. Even if chromosome painting shows that HAS 7 synteny is highly conserved, GTG-banding comparison in Hominoidea and Cercopithecoidea indicates the probable occurrence of complex rearrangements during the evolution. In this study we used a single locus FISH approach, a powerful tool to detect fine rearrangements, in order to investigate the evolution of HAS 7. We report the chromosome mapping of Williams-Beuren syndrome locus (WS - HSA 7q11.23) on Macaca fascicularis (MFA), Cercopithecus (Chlorocebus) aethiops (CAE) and Trachypithecus cristatus (TCR) (Cercopithecoidea, Primates). The probe hybridises on all species tested and demonstrates the occurrence of rearrangements like fusion, fission and pericentric plus paracentric inversions respectively in MFA, CAE and TCR. Together with the first chromosome mapping of WS locus in Cercopithecoidea, this study confirms that single locus mapping is a very efficacious tool for the analysis of chromosomal rearrangements as it gave the opportunity to have a fine molecular confirmation to proposed banding patterns homologies

    Scienza e valori morali

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    Il saggio discute criticamente la tesi della neutralità morale della scienza e delle applicazioni tecnologiche della scienza
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