1,721,160 research outputs found
Reply to comments by Laffon et al.: Liver SUV versus stage in Hodgkin's lymphoma: the total amount of uptake may play a role in the inverse relationship
No full textProstate Cancer: From Molecular Imaging to Immunological and Target Therapies
No full textProstate cancer (PCa) is one of the most common malignancies and a leading cause of cancer-related deaths, affecting a million people worldwide with a particularly high burden in countries with a low human development index [...
Decoupled association between <sup>18</sup>F-FDG and <sup>18</sup>F-FDOPA uptake in a carcinoid of the thymus
No full text18F-choline PET/CT pitfalls in image interpretation: An update on 300 examined patients with prostate cancer
No full textObjectives: 18F-choline PET/CT is an important diagnostic tool in the management of patients with prostate cancer (PC). The aim of this study was to describe and discuss some abnormal sites of uptake that we observed, not due to PC recurrence.
Patients and Methods: Three hundred patients were submitted to 18F-choline PET/CT for staging or restaging of PC. Whole-body PET/CT was acquired 40 minutes after the 18F-choline administration.
Results: We found abnormal uptake of the tracer, not related to PC, in 48/300 patients (16%). Most of these findings were due to inflammatory processes. Furthermore, some malignant conditions, such as a case of colon cancer, a case of bladder carcinoma, and a multiple myeloma, were diagnosed. Mild uptake was also detected in some benign diseases, such as thymoma, adrenal adenoma, and sarcoidosis. Six patients showed focal brain uptake in correspondence to a meningioma.
Conclusions: It is necessary for nuclear physicians, during clinical practice, to consider the possibility of 18F-choline uptake in some benign or malignant conditions for the intrinsic pharmacologic property of the tracer. An accurate medical investigation, correlative imaging with CT and/or MRI with contrast agents, laboratory data, and above all, histologic examination are often necessary for correct diagnosis
A case of intracranial meningioma detected by 18F-choline PET/CT and examined by PET/MRI fusion imaging
No full textInnovative implantable medical devices: the role of polymers, and nano- and biotechnology
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Patient-specific left atrium contraction quantification associated with atrial fibrillation: A region-based approach
No full textBackground and objectives: Atrial fibrillation (AF) is a widespread cardiac arrhythmia that significantly impacts heart function. AF disrupts atrial mechanical contraction, leading to irregular, uncoordinated, and slow blood flow inside the atria which favors the formation of clots, primarily within the left atrium (LA). A standardized region-based analysis of the LA is missing, and there is not even any consensus about how to define the LA regions. In this study we propose an automatic approach for regionalizing the LA into segments to provide a comprehensive 3D region-based LA contraction assessment. LA global and regional contraction were quantified in control subjects and in AF patients to describe mechanical abnormalities associated with AF. Methods: The proposed automatic approach for LA regionalization was tested in thirteen control subjects and seventeen AF patients. After dividing LA into standard regions, we evaluated the global and regional mechanical function by measuring LA contraction parameters, such as regional volume, global and regional strains, regional wall motion and regional shortening fraction. Results: LA regionalization was successful in all study subjects. In the AF group compared with control subjects, results showed: a global impairment of LA contraction which appeared more pronounced along radial and circumferential direction; a regional impairment of radial strain which was more pronounced in septal, inferior, and lateral regions suggesting a greater reduction in mechanical efficiency in these regions in comparison to the posterior and anterior ones. Conclusion: An automatic approach for LA regionalization was proposed. The regionalization method was proved to be robust with several LA anatomical variations and able to characterize contraction changes associated with AF
Molecular and Metabolic Imaging of Castration-Resistant Prostate Cancer: State of Art and Future Prospects
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