48 research outputs found
Fattori che influenzano il valore – Le sinergie applicate al caso Yoox-Net a Porter
No full textIl valore delle sinergie come componente del prezzo in un’operazione di M&A, Il caso YNAP e le sinergie, Perché molte operazioni di M&A falliscono: la difficoltà
di implementare le sinergi
Utilizzare le metodologie di valutazione in ottica di M&A – L’analisi del caso Yoox-Net a Porter
No full textFornire gli strumenti per poter esercitarsi a utilizzare i metodi di valutazione aziendale attraverso un caso pratico: l’acquisizione di Yoox-Net a Porter da parte di Richemont
Evidenziare i passaggi pratici nelle analisi di valutazione in ottica di M&A e i maggiori pregi e difetti dei vari metodi utilizzati nella pratic
Il ruolo degli investitori istituzionali nei processi di M&A – il Private Equity
No full textDefinire il private equity e fornire un quadro introduttivo dei meccanismi di funzionamento dei fondi preposti a tale attività
Comprendere i contesti tipici degli interventi del private equity e l’impat- to economico di tali operazioni sulla crescita e sulla trasformazione delle aziende
Comprendere la struttura di questa tipologia di operazioni, i fattori chiave di successo e le leve di creazione del valor
Metabolic syndrome among children and adolescents from Southern Italy: Contribution from the Calabrian Sierras Community Study (CSCS)
No full textPsychiatric referral in the terminally ill patient
No full textThe distinction between physiological and dysfunctional emotions in end-of-life care may be hard, for a twofold reason: on the one hand, the patient as a subject, with specific clinical features, personality, system of values; on the other hand, the clinical judgment by involved health professionals, particularly their specific cut-offs in discrimination between normal suffering and psychopathology. Both excessive/untimely medicalization and underestimation of medical conditions such as anxiety, depression, suicidal ideation, and insomnia may be a risk while dealing with end-of-life patients. Prompt, reliable psychiatric diagnosing contributes significantly to the major goal of dignity in death. The aims of a psychiatric consultation for patients with end-stage diseases should be: controlling concomitant psychiatric symptoms, managing pain and physical symptoms, assisting patient and relatives in the crisis-management, mediating conflicts between patient, family and ward personnel, and planning advocacy
Epigenetic regulation of Wnt7b expression by the cis-acting long noncoding RNA Lnc-Rewind in muscle stem cells
No full textSkeletal muscle possesses an outstanding capacity to regenerate upon injury due to the adult muscle stem cells (MuSCs) activity. This ability requires the proper balance between MuSCs expansion and differentiation which is critical for muscle homeostasis and contributes, if deregulated, to muscle diseases. Here, we functionally characterize a novel chromatin-associated lncRNA, Lnc-Rewind, which is expressed in murine MuSCs and conserved in human. We find that, in mouse, Lnc-Rewind acts as an epigenetic regulator of MuSCs proliferation and expansion by influencing the expression of skeletal muscle genes and several components of the WNT (Wingless-INT) signalling pathway. Among them, we identified the nearby Wnt7b gene as a direct Lnc-Rewind target. We show that Lnc-Rewind interacts with the G9a histone lysine methyltransferase and mediates the in cis repression of Wnt7b by H3K9me2 deposition. Overall, these findings provide novel insights into the epigenetic regulation of adult muscle stem cells fate by lncRNAs
Low dose chromium-polynicotinate or policosanol is effective in hypercholesterolemic children only in combination with glucomannan
No full textObjective: A low-fat, fiber-rich diet is the first step in the management for hypercholesterolemic children. Glucomannan (GM) is a natural fiber that has been demonstrated to lower total and LDL-cholesterol. The use of high-dose chromium-polynicotinate (CP) and policosanol (PC) has also shown cholesterol-lowering benefits. We aimed at investigating the effects of low-dose CP or PC and their GM combination in hypercholesterolemic children. Methods: A double-blind trial was conducted in 120 children (60 M, 60 F, 9 ± 4 years, median 9.6 years, range: 3-16 years) randomly assigned to 5 neutraceutical and 1 placebo (only resistant starch) 8-week treatment groups. Fasting blood glucose (FBG), total cholesterol (CholT), triglycerides (TG), HDL and LDL cholesterol were considered. Results: GM combination of low-dose CP or PC reduced CholT and LDL without changing HDL, TG and FBG. The highest post-treatment changes were seen after GM combination with CP (CholT 85 ± 3% and LDL 85 ± 5%, of pretreatment) which was significantly (p < 0.01) less than with low-dose CP or PC and starch. When GM was associated with starch, there was no lipid lowering effect, which was an unexpected finding as compared to previous data with GM and no starch. No adverse effects were reported. Conclusion: This is the first report to show the cholesterol-lowering efficacy of GM combined treatment with low-dose CP or PC. Further studies are needed to investigate the best combinations and doses of nutraceutics to be added to the standard GM treatment. The potential negative association of GM and nutraceutics with starch is clearly shown. © 2013 Elsevier Ireland Ltd
Discoloration of the smalt pigment: experimental studies and ab initio calculations
No full textSmalt is a blue pigment used by many European artists in mural and easel paintings, mainly in the period from the XV to XVIII century. It is a potassium glass where cobalt is added to the glassy matrix to get the blue hue. The pigment deteriorates with age, changing its colour from an intense blue to a grey-yellowish hue, causing severe problems in the conservation of the paintings. In this study a set of specimens of smalt dispersed in linseed oil was prepared and artificially aged to simulate the progressive deterioration of the pigment in a painting on canvas. The artificially aged smalt specimens were compared with some samples of naturally aged smalt taken from a banner painted at the end of XV century by Luca Signorelli, the “Baptism of Jesus”. A multi-technique approach, including SEM-EDX, spectro-colorimetry, X-ray absorption spectroscopy and ab initio calculations, was used to understand the progressive discoloration and to reveal its correlation with changes occurring in the pigment structure
Arterial blood pressure and serum lipids in a population of children and adolescents from Southern Italy: The Calabrian Sierras Community Study (CSCS)
No full textBackground: Lipid standards in Italy are lacking in children and adolescents whereas those for blood pressure (BP) were derived from US surveys. Methods: In a 14-town community in Southern Italy 1657 (64%) of 2594 children aged 6-14 years were enrolled and anthropometric, BP, lipid and glucose serum levels were obtained. Results: Average systolic BP was 101 +/- 11 (60-150) mm Hg and cholesterol (CholT) level was 156 +/- 28 (57-264) mg/dl. There were positive (p<0.00001) age-trends for systolic BP and body mass index (BMI) in both genders whereas age-trends for CholT and heart rate were negative (p<0.00001). A negative age-trend in both genders was also seen for non-HDL cholesterol (p<0.03). Based on 95% percentile gender and age distributions, there were 177 (10.68%) hypertensive (HT) and 82 (4.94%) hypercholesterolemic (HC) children or adolescents. Univariately, HT had higher (p<0.00001) height, weight, BMI, arm circumference, hips, waist, diastolic BP and waist/height, whereas HC had higher LDL-, HDL and non-HDL-cholesterol and triglycerides (p<0.01). Systolic BP was predicted (r(2)=0.2810, p=0.00001) by age (t=2.319, p<0.0205), male gender (t=3.179, p<0.0015), glucose (t=2.357, p<0.0186), height (t=2.473, p<0.0135), arm circumference (t=3.313, p<0.0009) and heart rate (t=4.161, p<0.00001). CholT was related inversely (r(2)=0.1399, p=0.00001) to height (t=-3.928, p<0.0001), weight (t=-3.922, p<0.0001) and waist/height (t=-4.797, p<0.00001) and directly to BMI (t=3.064, p<0.0022), waist (t=5.149, p<0.0000), triglycerides (t=11.332, p<0.00001) and female gender (t=-2.041, p<0.0414). Conclusion: In these Southern Italian children and adolescents systolic BP and CholT are related with anthropometric and other variables, not confined to height. BP is lower than previously reported. (C) 2012 Elsevier Ireland Ltd. All rights reserved
