81 research outputs found
Underwater Mediterranean image analysis based on the compute continuum paradigm
No full text14 pages, 11 figures, 6 tables.-- Data availability: Data will be made available on request: Francescangeli, Marco; Aguzzi, Jacopo; Marini, Simone; Martínez, Enoc; Nogueras, Marc; Toma, Daniel M.; Carandell, Matias; Masmitja, Ivan; Sarriá, David; García-Benadí, Albert; Cadena, Javier; Bghiel, Ikram; Artero Delgado, Carlota; Vidal, Neus; Gomáriz, Spartacus; Olivé Duran, Joaquim; Santamaria, Pep; Mànuel-Làzaro, Antoni; Río, Joaquín del; 2022; Underwater camera photos with manual tagging of fish species at OBSEA seafloor observatory from 2013 to 2014 [Dataset]; PANGAEA; https://doi.org/10.1594/PANGAEA.946149Human activity depends on the oceans for food, transportation, leisure, and many more purposes. Oceans cover 70% of the Earth’s surface, but most of them are unknown to humankind. This is the reason why underwater imaging is a valuable resource asset to Marine Science. Images are acquired with observing systems, e.g. autonomous underwater vehicles or underwater observatories, that presently transmit all the raw data to land stations. However, the transfer of such an amount of data could be challenging, considering the limited power supply and transmission bandwidth of these systems. In this paper, we discuss these aspects, and in particular how it is possible to couple Edge and Cloud computing for effective management of the full processing pipeline according to the Compute Continuum paradigmThis work was partially funded by the European Union - NextGenerationEU and by the Ministry of University and Research (MUR), National Recovery and Resilience Plan (PNNR), Mission 4, Component 2, Investment 1.5, project “RAISE - Robotics and AI for Socio-economic Empowerment” - (ECS00000035); The co-author Simone Marini is part of the critical mass of the RAISE Innovation Ecosystem.
It is also funded by the Project “National Biodiversity Future Center - NBFC” funded under the National Recovery and Resilience Plan (PNNR), Mission 4 Component 2 Investment 1.4 - Call for tender No. 3138 of 16 December 2021, rectified by Decree n.3175 of 18 December 2021 of Italian Ministry of University and Research funded by the European Union – NextGenerationEU; Project code CN_00000033, Concession Decree No. 1034 of 17 June 2022 adopted by the Italian Ministry of University and Research, CUP D33C22000960007.
The research was also supported by the ICM-CSIC “Severo Ochoa Centre Excellence” (CEX2019-000928-S) and the Research Unit Tecnoterra (ICM-CSIC/UPC) . Funds were also from DIGI4ECO (grant number 101112883 - GAP-101112883)Peer reviewe
Treatment of mild malnutrition and reduction of morbidity in major abdominal surgery: randomized trial on 153 patients]
No full textSevere malnutrition (defined as weight loss more than 10% in a period of six months) is considered an important risk factor in major abdominal surgery, because of a higher post-operative mortality and morbidity. The aim of our study is to assess the role of mild malnutrition (weight loss low than 10% in a period of six months) as a risk factor in major abdominal surgery and to evaluate the efficacy of therapy in order to improve outcomes in terms of in-hospital mortality, length of hospital stay and post-operative complications. Moreover, we evaluated serum albuminemia and lymphocyte count, important nutritional index, as predictive risk factors. We performed a randomized prospective trial, and admitted in our institution 153 adult patients, 43 with mild malnutrition and 110 without. The malnourished patients were randomized in two groups: the first one received oral immunonutrition (Impact Oral) for 7-10 days before surgery (22 pz), the second one received no nutritional support. We observed a higher number of complications in the non-treated malnourished patients (57%) versus both the treated malnourished patients (13.6%) and the normal group (19%) (p<0.001). Increased morbidity was observed in patients with serum albuminemia <2.8 gr/dl (69.2%) and with lymphocyte count <1.500 mm3 (57%). Nutritional enriched support demonstrated his efficacy in reducing morbidity, and length of hospital stay. Pre-operative oral immunonutrition might be suggested and established in all the patients with mild malnutrition that will be operated on major abdominal surger
Rectal cancer surgery with sphincter preservation: functional results related to the level of the anastomosis. Clinical and instrumental study
No full textBACKGROUND/AIMS: Unsatisfactory functional results have been reported not only after coloanal anastomosis, but also after anterior resection with colorectal anastomosis. The aim of this study is to establish functional outcome predictive factors related to surgical technique and especially the real impact of residual rectum length to identify patients who could benefit from colonic pouch reconstruction. METHODOLOGY: Sphincter preservation was achieved in 214 of 327 patients who underwent surgery for rectal cancer. Patients have been subdivided according to the level of anastomosis measured by a rigid proctoscope from the anal verge. In 93 patients functional results have been assessed by clinical control and anorectal manometry. RESULTS: Functional alterations such as leakage (13%), incontinence (5%), urgency (5%) and difficulty in evacuation (10%) appeared in patients who underwent anterior resection with anastomosis 4 to 6 cm from the anal verge. Nevertheless, comparing anterior resection with anastomosis 6 to 8 cm and that with anastomosis 4 to 6 cm rectal compliance was the only parameter whose difference is statistically significant. CONCLUSIONS: This result makes us to believe that patients who undergo anterior resection with no more than 2-3 cm of residual rectum could benefit from a colonic pouch reconstruction
Ritmos biológicos en la cigala (Nephrops norvegicus L.): modulación ecológica y bases genéticas
No full textMemoria de tesis doctoral presentada por Valerio Sbragaglia para optar al grado de Doctor en Ciencias del Mar por la Universitat Politécnica de Catalunya (UPC), realizada bajo la dirección del Dr. Jacopo Aguzzi del Institut de Ciències del Mar (ICM-CSIC).-- 99 pages[EN] Nephrops norvegicus is an important fishery resource for Europe. Its rhythmic burrowing behavior is strictly related to catchability. Here I studied such behavior under laboratory conditions. I investigated the combined effect of light and current cycles demonstrating that tidal current is an important parameter to take in account in fishery management plan not only for Nephrops. Then I used a transcriptomics and RT-qPCR approach on cDNA extracted from the eyestalk to elucidate the putative molecular genetics mechanisms underlying circadian gene regulation. My data are in accordance with the current knowledge of the crustacean circadian clock, reinforcing the idea that the molecular clockwork of this group shows some differences with the established model in Drosophila melanogaster. Finally, I studied the burrow emergence behavior in group of 4 lobsters organized in dominance hierarchy demonstrating that lower ranks are more vulnerable to trawling. I hypothesized common neural mechanisms for agonistic and non-agonistic behaviors[ES] Nephrops norvegicus es un importante recurso pesquero. La emergencia rítmica de la madriguera afecta las capturas. He estudiado dicho comportamiento en laboratorio investigando el efecto de ciclos lumínicos y de corrientes demostrando que las mareas es un factor importante para gestionar el estado del recurso. Mediante técnica de secuenciación masiva y PCR en tiempo real sobre cDNA procedente del pedúnculo ocular he elucidado el presunto mecanismo molecular detrás de la regulación circadiana. Los resultados están de acuerdo con el conocimiento actual de relojes biológicos en crustáceos, reforzando la idea que la maquinaria molecular de este grupo muestra algunas diferencias respecto el modelo consolidado de Drosophila melanogaster. Finalmente, he estudiado el comportamiento de emergencia en grupos de 4 cigalas organizadas en una jerarquía de dominancia demostrando que los rangos más bajos son más vulnerables a ser capturados. Además he supuesto la existencia de mecanismos neuronales comunes entre comportamiento agonístico y non agonísticoThe author has been financed by a FPI pre-doctoral grant from august 2011 to July 2015 (BES-2011-045187). The research presented in this thesis was carried out in the framework of the project RITFIM (CTM2010-16274)Peer Reviewe
Towards naples ecological research for augmented observatories (NEREA): The NEREA-fix module, a stand-alone platform for long-term deep-sea ecosystem monitoring
No full textDeep-sea ecological monitoring is increasingly recognized as indispensable for the comprehension of the largest biome on Earth, but at the same time it is subjected to growing human impacts for the exploitation of biotic and abiotic resources. Here, we present the Naples Ecological REsearch (NEREA) stand-alone observatory concept (NEREA-fix), an integrated observatory with a modular, adaptive structure, characterized by a multiparametric video-platform to be deployed in the Dohrn canyon (Gulf of Naples, Tyrrhenian Sea) at ca. 650 m depth. The observatory integrates a seabed platform with optoacoustic and oceanographic/geochemical sensors connected to a surface transmission buoy, plus a mooring line (also equipped with depth-staged environmental sensors). This reinforced high-frequency and long-lasting ecological monitoring will integrate the historical data conducted over 40 years for the Long-Term Ecological Research (LTER) at the station “Mare Chiara”, and ongoing vessel-assisted plankton (and future environmental DNA-eDNA) sampling. NEREA aims at expanding the observational capacity in a key area of the Mediterranean Sea, representing a first step towards the establishment of a bentho-pelagic network to enforce an end-to-end transdisciplinary approach for the monitoring of marine ecosystems across a wide range of animal sizes (from bacteria to megafauna)
Treatment-free remission in Chronic Myeloid Leukemia harboring atypical BCR-ABL1 transcripts.
No full textDiscontinuation of tyrosine kinase inhibitors (TKI) is the main goal today in the field of Philadelphia positive chronic myeloid leukemia (Ph + CML) and the criteria to attempt the interruption of therapy are well defined and rely on the possibility to regularly monitor the BCR-ABL1 transcript. Patients harboring atypical transcripts are automatically excluded from protocols due to the absence of a standardized method of quantification of their minimal residual disease (MRD). We report here the outcome of 6 patients with atypical transcripts with a long follow up whose MRD was followed in three cases with digital PCR during their treatment free remission (TFR)
Retrospective analysis of 260 patients with essential thrombocythemia: iwg-mrt (ipset model; passamonti et al, blood 2012) prognostic score is a good predictor of survival
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Actions louder than words: reading narrative silence as literary creation in the Brontës
No full textThe purpose of this study is to interrogate how women's silences in Victorian literature, and in the Brontë canon more specifically, are calculated to facilitate female expression through diverse modes of creative and expository narrative. As a response to second-wave feminist scholarship and its emphasis on female silence as oppressive, this thesis considers the role of metafiction in Charlotte Brontë's Jane Eyre (1847), Emily Brontë's Wuthering Heights (1847), and Anne Brontë's The Tenant of Wildfell Hall (1848), in order to refocus attention from their heroines' subdued dialogue to more forceful, and often covert, forms of narrative control. Each chapter centers on a separate heroine, spanning the works' mid-century publication dates (1847-1848), in chronological order. The first chapter juxtaposes Jane Eyre as a largely silent character in volumes I and II, against her position as narrator, pseudo-author, and inevitably, editor, in the creation and publication of her autobiography – roles that develop in the third volume. Chapter 2 centres on Catherine Earnshaw's narrative authority through the haunting, as well as enchanting effect of her journal in Wuthering Heights. The third and final chapter then investigates Helen Graham's censorial command over her life story as a counter-narrative, opposite the community's gossip, in The Tenant of Wildfell Hall. Ultimately, this project examines the protagonists' interactions with books, letters, and journals and the way that those actions capitalize on the (often understated) power of silence in order to incorporate gendered perspectives and social criticisms into the mid-century novel, and by extension, the greater public's consciousness.Le but de cette étude est de comprendre le silence des femmes victoriennes, particulièrement dans le canon des Brontës, non comme obstacle, mais bien comme élément calculé pour faciliter l'expression féminine. Afin de répondre aux préoccupations soulevés par la deuxième vague féministe quant à la dimension oppressive du silence, le rôle de la métafiction sera considéré dans les livres suivants – Jane Eyre (1847), de Charlotte Brontë; Wuthering Heights (1847), de Emily Brontë; et The Tenant of Wildfell Hall (1848), d'Anne Brontë – ce qui permettra de valoriser le contrôle narratif exercé subtilement par leurs héroïnes, en dépit de leur silences qui témoignerait d'une subjugation oppressive. Chaque chapitre se concentre sur une héroïne différente dans chacune des oeuvres, selon l'ordre chronologique de leurs dates de parutions, entre 1847-1848. Dans le premier chapitre, le silence du personnage de Jane Eyre dans les volumes I et II est juxtaposé au rôle qu'elle développe dans le troisième volume, en tant que narratrice, auteure, et éditrice de son autobiographie. Le deuxième chapitre met en évidence l'autorité narrative de Catherine Earnshaw par le biais de son journal enchanteur dans Wuthering Heights. Le troisième et dernier chapitre se penche sur la commande censoriale que dispose Helen Graham dans The Tenant of Wildfell, pour opposer les rumeurs de la communauté quant au récit de sa vie. Ultimement, ce projet examine la manière que les protagonistes capitalisent sur le pouvoir mal compris du silence en se servant de livres, de lettres et de journaux, pour incorporer des perspectives féminines et des critiques sociales dans le roman victorien ainsi que par extension, dans la conscience du public
Bosutinib in the Real-Life Treatment of Chronic Phase Chronic Myeloid Leukemia (CML) Patients Aged > 65 Years Resistant/Intolerant to Frontline Tyrosine-Kynase Inhibitors
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