5,121 research outputs found
Short-term effects of air pollution and temperature on daily morbidity in Chiang Mai Thailand
Get PDFAir pollution is associated with mortality and morbidity worldwide. Hot and cold temperature is also related to increased deaths and possibly hospital visits and admissions in many settings. Climate change is anticipated to pose increasing risks of deaths and illnesses associated with air pollution and temperature variations, particularly in developing world. To date, research studies about health effects of air pollution and temperature have been conducted in developed countries with cool climate more than in developing countries with subtropical or tropical climate. Furthermore, studies to identify susceptible populations are still limited. This study aims to investigate heath effects of air pollution and temperature and to identify people who are more susceptible to air pollution and temperature in a developing, tropical country, Thailand.
A regression analysis of retrospective time series data was employed to assess the shortterm effects of air pollution and temperature on daily out-patient visits and hospital admissions in Chiang Mai, Thailand, from October 2002 to September 2006. Generalised negative binomial regression was used to model the relationships between the exposure and health outcomes, controlling for seasonal patterns and other possible potential confounders. Lag effects up to 4 days for air pollution, and up to 13 days for temperature were considered. Effect modification by age, sex, occupation, season, and previous out-patient visits before admissions were also examined.
There were positive, but not significant, effects of air pollution for some pollutants (particularly for S02), with notably larger effect sizes compared to previous studies in Western countries. There was evidence of hot temperature effects (though wide confidence intervals), with an increase in diabetic visits of 26.3% (95% Cl, 7.1% to 49.0%), and in circulatory visits of 19.2% (95% Cl, 7.0% to 32.8%) for each 1°C increase in temperature above 29°C. There was a rise of both the visits (3.7% increase, 95% Cl, 1.5% to 5.9%) and admissions (5.8% increase, 95% Cl, 2.3% to 9.3%) due to intestinal infectious disease for each 1°C increase across the whole temperature range. Despite no statistically significant differences between subgroups, air pollution effects were stronger in the elderly, females and manual workers, whereas temperature effects were stronger in the elderly, male and unemployed people.
This study suggests that while there was little evidence of air pollution effects, there was significant evidence of high temperature effects on daily morbidity in Chiang Mai. The elderly seemed to be more vulnerable to the daily changes of both air pollution and temperature
Building a medical decision support system for colon polyp screening by using fuzzy classification trees
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The SSC of the Generalised Jahangir’s Graph Jm,k and its Algebraic Characterizations
No full textIn this article, we present important combinatorial and algebraicproperties of spanning simplicial complex (SSC) of the generalised Jahangir’sgraph Jm,k. We describe the relation to find f−vectors associatedto Δs(Jm,k) and determine the Hilbert series for the SR-ring KΔs(Jm,k).In the end, we present the associated primes of the facet ideal IF(Δs(Jm,k))and the Cohen-Macaulay characterization of the SR-ring of Δs(Jm,k).AMS (MOS) Subject Classification Codes: Primary 13-P10, Secondary 13-F20, 13-C14, 13-H10.Corresponding Author: Agha KashifKey Words: Simplicial Complexes, f-vectors, Spanning Trees, Face Ring, Hilbert Series, CohenMacaulay
To <i>JM</i> on Its 75th Anniversary
No full text This article discusses how Journal of Marketing ( JM) has influenced marketing science and practice by publishing articles on substantive topics relevant to customers, managers, organizations, markets, and society. The journal's 75th anniversary coincides with the 50th anniversary of the Marketing Science Institute (MSI). Frequently, JM and MSI have collaborated to address important substantive marketing issues identified in MSI's Research Priorities. The author highlights seminal articles on brand equity; business-to-business marketing (including sales force management); connecting marketing information, metrics, and strategy; consumer behavior; innovation, new product development. and product management; marketing orientation and capabilities; and market research, methodology and services. She also draws attention to articles that have won the Sheth Foundation/ JM Award and the H. Paul Root Award. The article describes how JM‘s knowledge dissemination is amplified by powerful social network effects. Ideas in JM articles diffuse through the business community, influencing the mind-set of managers worldwide. </jats:p
JM-20, a Benzodiazepine-Dihydropyridine Hybrid Molecule, Inhibits the Formation of Alpha-Synuclein-Aggregated Species
No full text\ua9 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.Studies showed that JM-20, a benzodiazepine-dihydropyridine hybrid molecule, protects against rotenone and 6-hydroxydopamine neurotoxicity. However, its protective effects against cytotoxicity induced by endogenous neurotoxins involved in Parkinson’s disease (PD) pathogenesis have never been investigated. In this study, we evaluated the ability of JM-20 to inhibit alpha-synuclein (aSyn) aggregation. We also evaluated the interactions of JM-20 with aSyn by molecular docking and molecular dynamics and assessed the protective effect of JM-20 against aminochrome cytotoxicity. We demonstrated that JM-20 induced the formation of heterogeneous amyloid fibrils, which were innocuous to primary cultures of mesencephalic cells. Moreover, JM-20 reduced the average size of aSyn positive inclusions in H4 cells transfected with SynT wild-type and synphilin-1-V5, but not in HEK cells transfected with synphilin-1-GFP. In silico studies showed the interaction between JM-20 and the aSyn-binding site. Additionally, we showed that JM-20 protects SH-SY5Y cells against aminochrome cytotoxicity. These results reinforce the potential of JM-20 as a neuroprotective compound for PD and suggest aSyn as a molecular target for JM-20
Uterine transplantation: a promising surrogate to surrogacy?
No full textUterine transplantation: a promising surrogate to surrogacy?
Grynberg M1, Ayoubi JM, Bulletti C, Frydman R, Fanchin R.
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Abstract
Infertility due to the inability of the uterus to carry a pregnancy ranks among the most unresolved issues in reproductive medicine. It affects millions of women worldwide who have congenital or acquired uterine affections, often requiring hysterectomy, and potentially represents a considerable fraction of the general infertile population. Patients suffering from severe uterine infertility are currently compelled to go through gestational surrogacy or adoption; both approaches, unfortunately, deprive them of the maternal experience of pregnancy and birth. Uterine transplantation represents an outstanding, yet complex, perspective to alleviating definitive uterine infertility. In the past decades, a number of scientific experiments conducted both in animals and women, focusing on uterine transplantation, have led to promising results. Collectively, these findings undoubtedly constitute a sound basis to clinically apply uterine transplantation in the near future. This paper is, however, an overview not only of the extent and limitations of accumulated scientific knowledge on uterine transplantation, but also its ethical implications, in an effort to define the actual place of such an approach among the therapeutic arsenal for alleviating infertility.
© 2011 New York Academy of Sciences
Translation and interpretation: Translation redundancy reconsidered
No full textInterpretation is an integral part of the process of translating. This article raises the question of whether interpretation fo a literary work by a translator should be guided by extratextual factors or not. The discussion is illustrated with examples taken from David Hawkes' translation of a Chinese classic, A Dream of Red Mansions. As the work of a scholar-translator, Hawkes' version is richly supplemented with disclosures concerning the characters and explanations of the cultural environment embodied in the novel. In many cases, however, this translation procedure is redundant and explanatory, enlightening the readers but at the same time robbing them of the pleasure of literary interpretation and cultural exploration. By means of this illustration of translation redundancy, the author points out that there is difference between a scholar who helps the interpretation fo a work and a translator who presents a work close to its original version. It is particularly important to pay attention tot his difference in literary translations in a cross-cultural situation involving two enormously different cultures.Language & LinguisticsA&HCI0ARTICLE1,SI115-12
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