1,721,517 research outputs found
Neuroprotective effects of adiponectin in focal cerebral ischemia
No full textpublished_or_final_versionabstractMedicineMasterMaster of Philosoph
Role of cerebral ischemia in cognitive impairment: clinical and experimental study
No full textpublished_or_final_versionabstractMedicineDoctoralDoctor of Philosoph
Heart rate variability and outcome in acute stroke
No full textpublished_or_final_versionMedicineMasterMaster of Philosoph
Neuroprotection of melatonin against experimental intracerebral hemorrhage
No full textpublished_or_final_versionMedicineDoctoralDoctor of Philosoph
Association of adiponectin gene variants and adiponectin level with ischemic stroke in a Chinese cohort
No full textpublished_or_final_versionMedicineMasterMaster of Philosoph
Evaluation of a novel post-stroke epilepsy model in the rat
No full textWith the development of treatment and reduction in mortality after stroke, current research focuses more on the disabilities of survivors. Post-stroke epilepsy (PSE) is one of the common complications of stroke. PSE is defined as recurrent epileptic seizures following stroke. Many stroke models have been used to study the mechanisms behind PSE. However, the low success rate of PSE in these models has been a major limitation. To address this problem, we have developed a novel rat model of PSE. In this PSE model, temporal lobe epilepsy (TLE) was induced one week after the creation of photothrombotic stroke. Video monitoring was used to estimate the frequencies of spontaneous recurrent seizures (SRS) 6 to 8 weeks after installation of TLE. Morris water maze (MWM), open field, and three hyperexcitability tests were used to analyse spatial memory, anxiety, and aggressivity, respectively. Our data revealed that the PSE group has an aggravated aggression intensity, impaired anxiety, brain atrophy, mossy fiber sprouting (MFS) when compared to the Lithium-pilocarpine (LIP) epilepsy group. However, there was no significant difference in SRS frequency. In addition, we evaluated the benefits of melatonin as a treatment in this PSE model. Our present results showed that melatonin mitigated impaired spatial memory and reduced impaired anxiety, aggression intensity and brain atrophy when compared to vehicle. Furthermore, melatonin attenuated the abnormal MFS, and decreased serum corticosterone concentration in brain tissues when compared to vehicle. However, melatonin did not significantly reduce SRS frequency.published_or_final_versionMedicineDoctoralDoctor of Philosoph
The clinical characteristics and thyroid hormone levels of neuro-long COVID among Hong Kong adults
No full textAccording to the US Centre for Disease Control and Prevention, Long COVID is defined by unexplained persistent symptoms lasting for 4 weeks or more upon the onset of acute infection. Over 30% of COVID-19 survivors experience persistent neurological, neuropsychological or neuropsychiatric symptoms, i.e. Neuro-Long COVID, which is debilitating and causes immense healthcare burden. At present, there is no consensus on Neuro-Long COVID management simply because of a lack of pathophysiological knowledge. The thyroid gland is a known target of COVID-19 infections. Thyroid hormones are important in regulating brain function, yet the association between thyroid hormone imbalance and Neuro-Long COVID remains unclear. We aim to better understand Neuro-Long COVID by describing 1) the epidemiology in Hong Kong adults; 2) the predictors and protective factors; 3) the association with thyroid hormone level; 4) the association with clinical assessment results and 5) a proposed definition for this novel syndrome.
A two-part cross-sectional study was conducted. First, a population-based online survey was performed among Hong Kong residents from April 2023 to May 2024. Demographics and information on COVID-19 infection(s) were collected. Further in-person assessments were conducted on a subset of participants to evaluate their neurological functioning. Serum samples were then collected to assess thyroid hormone levels. The Chi-square or Fisher’s exact test was used to compare group differences between demographic variables, as appropriate. Student’s t-test or one-way ANOVA was used to compare thyroid hormone levels between groups, as appropriate. Univariate and multivariate analyses were conducted to determine predictors of Neuro-Long COVID. Statistical significance was inferred when p <.05.
Among 5007 survey respondents, most general symptoms resolved within 4 weeks; fatigue (34.8%) was the most reported persistent symptom. Attention/concentration loss (34.4%) and memory disturbances (31.1%) are the most prevalent neurological persistent symptoms among COVID-19 survivors. Female sex, older age, community treatment facilities admission, pre-existing medical conditions, and repeated COVID-19 infections were significantly associated with an increased risk of developing Neuro-Long COVID; while reduced risk was observed in participants who were fully vaccinated. Pre-existing thyroid disorders were an independent risk factor of cognitive Neuro-Long COVID subtype. Among 378 subjects who participated in further assessments, individuals who scored lower in the MoCA memory subsection were more likely to develop Neuro-Long COVID. No significant differences between serum levels of free triiodothyronine (fT3) and thyroid stimulating hormone (TSH) were observed in the presence of Neuro-Long COVID and persistent fatigue, independently.
In summary, this thesis provided evidence regarding the epidemiology of Neuro-Long COVID in Hong Kong adults; the predictive value of pre-existing comorbidities, acute severe illness, and repeated infections; and the protective value of a full vaccination regimen for Neuro-Long COVID. Furthermore, thyroid function does not play an important role in the pathogenesis of Neuro-Long COVID. Based on our findings, the presence of ≥ 3 persistent neurological symptoms may serve as useful criteria for defining this novel syndrome. Future treatment guidelines for COVID-19 should reflect corresponding care for managing neurological symptoms among these high-risk populations.published_or_final_versionMedicineMasterMaster of Philosoph
Effectiveness of acupuncture in stroke rehabilitation
No full textpublished_or_final_versionMedicineDoctoralDoctor of Philosoph
Neuroprotection of melatonin in ischemic stroke models
No full textpublished_or_final_versionMedicineDoctoralDoctor of Philosoph
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