207 research outputs found
Robert Bly
No full textRobert Bly visited The College at Brockport in March 1970, December 1971, and April 1974. He is a poet, author, and activist known for Iron John: A Book About Men (1990).Archived web contentSUNY BrockportWriters Forum Author Photo
Robert Bly
No full textRobert Bly visited The College at Brockport in March 1970, December 1971, and April 1974. He is a poet, author, and activist known for Iron John: A Book About Men (1990).https://digitalcommons.brockport.edu/writers_photos/1005/thumbnail.jp
Robert Bly and the Twofold Consciousness
No full textHow beautiful to walk out at midnight in the moonlight/ dreaming of animals. It is samplings of Robert Bly\u27s poetry such as these which have prompted Eliot Weinberger to wonder, What kind of windbag and language slob would write such a line? But there are also such fine and startling images as The bare trees more dignified than ever or lamplight that falls on all fours in the grass, which Ian Hamilton admires. Hayden Carruth has encapsulated the view of many of Bly\u27s readers, who regard him as one of the most annoying and exciting poets of the 1960\u27s and 1970\u27s. Paul Ramsey has seen him as a political crank who invents wantonly cruel lies in the process of charging the government with cruelty and lies. William Heyen believes he is a Romantic in the Yeats strain, his Silence in the Snowy Fields comparable to a cluster of gnats. This converts Heyen unwillingly to praise of Bly\u27s poems: It will be impossible for me to discuss my change of mind rationally, but I\u27ve come to believe that my reservations about Bly were only nigglings, that measuring the accomplishment of his work against petty objections is something like dismissing Moby Dick because Melville loses track of his point of view. Bly is free from the inhibitions of critical dictates many of us have regarded as truths. These are not the voices of critics talking in their usual calm, confident tones about the tenor of an author \u27s work. Who is the poet Robert Bly who so influenced a generation of readers among which he was widely read and whose work has been the source of so much vexation and praise by critics and readers alike? He is a 58 year old Madison, Minnesota, farmer\u27s son. Bly was the second son his brother James was one and a half years older. Their mother, Alice Aws Bly, worked at the courthouse in Madison for many years, and the Bly children were cared for by Marie Schmidt. In addition, a hired farm hand named Art Nelson lived with the Bly’s for nine years. Bly described his father, Jacob, as a man who was both a reader and a farmer. Later it was Robert who became the reader of books and his brother James who became the farmer
Expression of integrin α5β1 and the relationship to collagen and elastin content in human suprarenal and infrarenal aortas
No full textThe infrarenal aorta is especially prone to the development of aneurysm, suggesting an intrinsic structural and molecular difference in different parts of the aorta. Previous study from this laboratory has implicated a potential role of integrin α5β1 in maintaining aortic integrity. The aim of this study was to investigate the expression of integrin α5β1 and the relationship to collagen and elastin content between 2 different aortic segments. In this study, the variation of smooth muscle cells and the localization of integrin α5β1 in the suprarenal and infrarenal aorta tissues removed from organ donors were studied immunohistochemically. The biochemical analysis for matrix proteins and integrin α5β1 protein was done by Western Blot on the corresponding tissues. All interested protein content was normalized to the smooth muscle α-actin protein. No significant difference of smooth muscle cells density between the 2 segments of aortas was observed. Integrin α5β1 was localized in the outer layer of all aortic media. The authors found that the ratio of collagen/elastin in infrarenal aortas was significantly increased 2-fold because elastin content in infrarenal aortas decreased 49% as compared with suprarenal aortas. Integrin α5β1 content relative to its specific ligand-collagen - did not differ between these 2 different aortic segments. These results suggest that the infrarenal aorta differed biochemically from the suprarenal aorta. A decrease in infrarenal elastin without a corresponding decrease in collagen and integrin α5β1 may affect the compliance and integrity of the distal aorta. These intrinsic anatomic differences may be important in the susceptibility of the infrarenal aortas to aneurysm formation. ©2005 Westminster Publications, Inc.link_to_subscribed_fulltex
Differential expression of integrin α5β1 in human abdominal aortic aneurysm and healthy aortic tissues and its significance in pathogenesis
No full textBackground Abdominal aortic aneurysm (AAA) is a common aged disease of human aorta with increasing incidence. It is characterized by dramatic vascular remodeling via proteolysis and degradation of matrix proteins. Integrins are important cellular receptors for matrix proteins, which may have an association with pathological remodeling. The present study was undertaken to analyze the expression of integrin subunits in human aneurysmal aortas and with healthy aortic tissues as controls. Materials and methods The expression of integrin genes in AAA specimens and healthy human aortic tissues was detected by RT-PCR technique. The correlation of variation and distribution of smooth muscle cells (SMCs) and integrin protein expression in the corresponding tissues were studied immunohistochemically. Results The gene transcripts coding for integrin α4, α5, αV, β1, β3, β5, and β6 subunits were constitutively expressed in the normal aortas. Only gene expressions of integrin α5 and β1 were significantly decreased by 81% and 85%, respectively, in AAA specimens (P < 0.005) when compared with healthy aortic specimens. No age dependence of the expression of integrin α5β1 genes was found. Significant reduction of medial SMC density was confirmed in corresponding AAA compared with control aortas. Immunoreactivity of integrin α5β1 receptor was found to be exclusively localized within the medial layer of the parallel normal aortic sections, whereas this protein was absent in the destructive media of aneurysmal aortic sections. Conclusions The marked decrease in integrin α5β1 expressions was unique to aneurysmal aortic tissues and correlated to a decrease in density of SMCs, which are the major cells in maintaining the structure stability of normal aortas. As integrin α5β1 specifically binds fibronectin and collagen, those results may suggest that the absence of integrin α5β1 activity impair matrix protein attachment and alter the architecture in aortic media thereby lead to the deformity of aorta and aneurysm formation. © 2004 Elsevier Inc. All rights reserved.link_to_subscribed_fulltex
Differential secretion of prostaglandin E2, thromboxane A 2and interleukin-6 in intact and ruptured abdominal aortic aneurysms
No full textRuptured abdominal aortic aneurysm (AAA) contributes largely to aneurysm-related morbidity and mortality. An inflammatory gene, COX-2, was found to be widely expressed in AAA. However, the involvement of COX-2 metabolites and other inflammatory mediators in the disease and particularly in AAA rupture still needs elucidation. The purpose of the present study was to evaluate the secretion of inflammatory mediators and the expression of macrophages in aneurysms and determine their significance in ruptured AAA. Aortic tissue was harvested at time of aortic reconstructive surgery for the group of intact AAA (n=20) and ruptured AAA (n=10) or at time of organ harvest for normal aortic tissue (n=4). Aortic explant cultures were immediately established and the culture medium was collected after 72 h. Specific enzyme-linked immunoassorbent assays were used to quantify COX-2 metabolites and inflammatory cytokines. Inflammatory macrophage cells were also quantified in the corresponding aortic walls immunohistochemically. Differences in the secretory levels of inflammatory metabolites and the macrophage quantity in all groups were assessed. All three explant culture groups secreted detectable levels of studied COX-2 metabolites, including PGE2, PGF2α, PGI2 and TxB 2 and inflammatory cytokines, including interleukin (IL)-1β, IL-6, IL-8 and IL-10. The secretory levels of PGE2, TXB2 and IL-6 were highest in the ruptured AAA explant cultures and statistically higher than those in intact AAA cultures (p>0.05). The secretion of those inflammatory mediators and the local expression of macrophages in ruptured aneurysm probably reflects the active inflammatory processes in the aortic lesions. A means of modifying the inflammatory process in the wall of AAAs might play an important role in preventing aneurysm rupture.link_to_subscribed_fulltex
Can local secretion of prostaglandin E2, Thromboxane B 2, and interleukin-6 play a role in ruptured abdominal aortic aneurysm?
No full textBackground: Our laboratory has previously shown that the levels of secreted prostaglandin E2 (PGE2), Thromboxane B2 (TxB2), and interleukin-6 (IL-6) by aortic explant cultures were high in patients with ruptured abdominal aortic aneurysm (AAA). In the present study, we sought to examine the secretory levels of these inflammatory mediators in aortic explant cultured from a group of AAAs rupturing at a certain size and a group that did not rupture at that size. It was thought that such a comparison might reveal the contribution of those inflammatory mediators to the risk of AAA rupture. Materials and methods: All subjects had abdominal computed tomography (CT) scans to determine the size of the aneurysm, and surgical aortic tissue was collected from both nonruptured AAAs (18 with a mean size of 6 + 0.5 cm [range: 5-7 cm] and 12 with a mean size of 8 + 0.1 cm [range: 7.01-10 cm]) and ruptured AAAs (10 with a mean size of 5.8 + 0.3 cm [range: 5-7 cm] and 10 with a mean size of 7.8 + 0.1 cm [range: 7.01-10 cm]). Aortic explant cultures from different sizes of aneurysms were immediately established and the culture media were collected 72 h later. Results: The levels of PGE2, TxB2, and IL-6 secreted in the cultured medium were quantified by specific enzyme-linked immunosorbent assays (ELISA). The secretary levels of PGE2, TxB2, and IL-6 were significantly higher in ruptured AAAs than in nonruptured AAAs of similar diameter. However, there was no correlation between these three inflammatory mediators and the size of AAA. Conclusions: This study shows that these inflammatory mediators may play a role in the progression toward rupture but may not be responsible for the expansion of AAA. © 2007 Société Internationale de Chirurgie.link_to_subscribed_fulltex
Nelly Bly
No full textA man sings about his wife adn their home.https://egrove.olemiss.edu/kgbsides_uk/1761/thumbnail.jp
The Adventures of Juan, the Fox: Argentine Tales and Fables
No full textEight stories, moving from shorter fables to expanded fables or folktales. The first two are traditional fables: "The Fox and the Jaguar" about sharing and "The Doe and the Fawn" about obeying a parent. The foreword is correct: the longer stories contain familiar fable motifs, like a farming partner cleverly choosing either what is above or what is below ground depending on the crop. Each story has a pleasant multi-colored illustration on a separate title-page that repeats the names of the author and illustrator. The name of the author is then repeated again on the next page, together with the story's title again. Several stories have a second and even a third image. This is apparently a print-upon-demand book.Edith Rusconi Kaltovic
Changes in inflammatory response after endovascular treatment for type B aortic dissection
No full textThis present study aims to investigate the changes in the inflammatory markers after elective endovascular treatment of Type B aortic dissection with aneurysm, as related to different anatomical features of the dissection flap in the paravisceral perfusion. Consecutive patients with type B aortic dissections with elective endovascular stent graft repair were recruited and categorized into different groups. Serial plasma levels of cytokines (Interleukin-1β, -6, -8, -10, TNF-α), chemokines (MCP-1), and serum creatinine were monitored at pre-, peri- and post-operative stages. The length of stent graft employed in each surgery was retrieved and correlated with the change of all studied biochemical parameters. A control group of aortic dissected patients with conventional medication management was recruited for comparing the baseline biochemical parameters. In total, 22 endovascular treated and 16 aortic dissected patients with surveillance were recruited. The endovascular treated patients had comparable baseline levels as the non-surgical patients. There was no immediate or thirty day-mortality, and none of the surgical patients developed post-operative mesenteric ischaemia or clinically significant renal impairment. All surgical patients had detectable pro-inflammatory mediators, but none of the them showed any statistical significant surge in the peri-operative period except IL-1β and IL-6. Similar results were obtained when categorized into different groups. IL-1β and IL-6 showed maximal levels within hours of the endovascular procedure (range, 3.93 to 27.3 higher than baseline; p = 0.001), but returned to baseline 1 day post-operatively. The change of IL-1β and IL-6 at the stent graft deployment was statistically greater in longer stent graft (p>0.05). No significant changes were observed in the serum creatinine levels. In conclusion, elective endovascular repair of type B aortic dissection associated with insignificant changes in inflammatory mediators and creatinine. All levels fell toward basal levels post-operatively suggesting that thoracic endovascular aortic repair is rather less aggressive with insignificant inflammatory modulation. © 2012 Cheuk et al.published_or_final_versio
- …
