103,256 research outputs found
Low noise high performance 50nm T-gate metamorphic HEMT with cut-off frequency f<sub>T</sub> of 440 GHz for millimeterwave imaging receivers applications
No full textThe 50 nm m-HEMT exhibits extremely high f<sub>T</sub>, of 440GHz, low F<sub>min</sub> of 0.7 dB, associated gain of 13 dB at 26 GHz with an exceptionally high Id of 200 mA/mm and gm of 950 ms/mm at low noise biased point
Off-take and slug transition at T-junction of vertical-up branch in the horizontal pipe
No full textThe off-take and the slug transition on air-water interface are experimentally investigated at the T-junction of the horizontal pipe with a vertical upward branch to simulate the loss-of-residual-heat-removal during a mid-loop operation in the Korea standard nuclear power plant. Scaling analysis is performed to scale down the experimental facility to the reference nuclear power plant. Two different diameters of branch pipes are used to verify the scaling laws and their scale effects. Air is used as working gaseous fluid and no water flow exists. Off-take behavior on horizontal stratified and slug flows is visually observed in the horizontal pipe. The experimental data are divided into three categories; onset of liquid entrainment at T-junction, onset of slug transition in the horizontal pipe, and discharge quality in the branch pipe. It is found out that the scale effect of the branch diameter on the onset of liquid entrainment is small and the existing correlations for it are applicable. Also, the onset of slug transition shows a discrepancy with Taitel-Dukler's correlation and has a strong influence on the discharge quality. New correlations for discharge quality are developed considering the critical dependency of the onset of slugging
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
Overview and Specification of the Built-In Types in Little Smalltalk
No full textThis document informally specifies the behavior of most of the key data types in the Little Smalltalk system.© 1991 Gary T. Leavens and Yoonsik Cheon. Permission is granted for you to make copies of this document for educational and scholarly purposes, but not for direct commercial advantage.</p
Study on the performance deterioration of flexible UWB antenna
No full textA flexible transparent film uwb antenna for
curved surfaces has been designed and developed for wireless communications. The antenna has demonstrated good performance over the entire UWB bandwidth. It can be
mounted on any conformal shape by virtue of the film properties of both the antenna as well as the substrate. The radiator and ground are both designed using AgHT-8 while
the substrate is of a polymer. The antenna is shown to be able to maintain its performance below the 10dB level throughout
the entire UWB bandwidth of 7.5GHz i.e from 3.1 GHz to 10.6 GHz as it is flexed through various radius of curvature thus providing an insight into how to overcome performance
deterioration in wearable antennas
Bayesian Nash equilibria and Bell inequalities
No full textGames with incomplete information are formulated in a multi-sector probability matrix formalism that can cope with quantum as well as classical strategies. An analysis of classical and quantum strategy in a multi-sector extension of the game of Battle of Sexes clarifies the two distinct roles of nonlocal strategies, and establish the direct link between the true quantum gain of game’s payoff and the breaking of Bell inequalities.Taksu Cheon and Azhar Iqba
Cellular heterogeneity of circulating CD4(+)CD8(+) double-positive T cells characterized by single-cell RNA sequencing
No full textCirculating CD4(+)CD8(+) double-positive (DP) T cells are associated with a variety of disease states. However, unlike conventional T cells, the composition of this population is poorly understood. Here, we used single-cell RNA sequencing (scRNA-seq) to analyze the composition and characteristics of the DP T cell population circulating in the peripheral blood of cynomolgus monkeys. We found that circulating DP T cells not only contain a large number of naive cells, but also comprise a heterogeneous population (CD4 CTL-, Eomes(+) Tr1-, Th2-, Th17-, Tfh-, Treg-, CD8 CTL-, and innate-like cells) with multiple potential functions. Flow cytometry analysis revealed that a substantial number of the naive DP T cells expressed CD8 alpha beta, as well as CD8 alpha alpha, along with high expression of CD31. Moreover, the CD4(hi)CD8(lo) and CD4(hi)CD8(hi) populations, which express high levels of the CD4 coreceptor, comprised subsets characterized by helper and regulatory functions, some of which also exhibited cytotoxic functions. By contrast, the CD4(lo)CD8(hi) population with high CD8 coreceptor expression comprised a subset characterized by CD8 CTL- and innate-like properties. Taken together, the data show that scRNA-seq analysis identified a more diverse subset of the circulating DP cells than is currently known, despite this population being very small.Y
CD4hiCD8low Double-Positive T Cells Are Associated with Graft Rejection in a Nonhuman Primate Model of Islet Transplantation
No full textPeripheral CD4/CD8 double-positive (DP) T cells are associated with autoimmune disorders, cancer, and viral infection. However, the relationship between organ transplantation and DP T cells is unclear. Here, we examined the functional characteristics of peripheral DP T cells and analyzed their significance with respect to islet graft rejection in a nonhuman primate model of islet transplantation. DP T cells were functionally equivalent to conventional CD4 and CD8 T cells in terms of helper and cytotoxic activity, respectively. DP T cells expressed high levels of CXCR5 and PD-1 and secreted IFN-γ, IL-4, and IL-21 in amounts equivalent to those secreted by CD4 or CD8 T cells; also, they produced large amounts of granzyme B and perforin. In addition, under steady-state conditions, DP T cells expressed eomesodermin (Eomes) and promyelocytic leukemia zinc finger (PLZF) proteins, both of which act as transcription factors in innate/memory-like T cells. The number of peripheral DP T cells in the islet transplantation model was high in the group that experienced graft rejection; this was not the case in the long-term survival group. Interestingly, numbers of effector memory T cells (TEM) within the DP T cell population increased significantly during islet graft rejection, as did those of TEM within the cytotoxic CD8 T cells. Furthermore, the most conspicuous of which was the increase of CD4hiCD8low T cell subpopulation at that point. Taken together, the data suggest that peripheral DP T cells showing an innate/memory-like phenotype have both helper and cytotoxic activity in vitro and that they may act as a novel biomarker for graft rejection after islet transplantation
Handwritten biographical information on Paulina T. McClung Merritt
No full textA handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
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