1,722,106 research outputs found
Cheng Chia-Jui (sous dir.), Clive M. Schmitthoffs Selected Essays on International Trade Law
No full textCheng Chia-Jui (sous dir.), Clive M. Schmitthoffs Selected Essays on International Trade Law. In: Revue internationale de droit comparé. Vol. 41 N°3, Juillet-septembre 1989. pp. 795-797
Cheng Chia-Jui (sous dir.), Clive M. Schmitthoffs Selected Essays on International Trade Law
No full textCheng Chia-Jui (sous dir.), Clive M. Schmitthoffs Selected Essays on International Trade Law. In: Revue internationale de droit comparé. Vol. 41 N°3, Juillet-septembre 1989. pp. 795-797
Induction of Non-Targeted Stress Responses in Mammary Tissues by Heavy Ions
No full textPurpose: Side effects related to radiation exposures are based primarily on the assumption that the detrimental effects of radiation occur in directly irradiated cells. However, several studies have reported over the years of radiation-induced non-targeted/ abscopal effects in vivo that challenge this paradigm. There is evidence that Cyclooxygenase-2 (COX2) plays an important role in modulating non-targeted effects, including DNA damages in vitro and mutagenesis in vivo. While most reports on radiation-induced non-targeted response utilize x-rays, there is little information available for heavy ions.
Methods and Materials: Adult female transgenic gpt delta mice were exposed to an equitoxic dose of either carbon or argon particles using the Heavy Ion Medical Accelerator in Chiba (HIMAC) at the National Institute of Radiological Sciences (NIRS) in Japan. The mice were stratified into 4 groups of 5 animals each: Control; animals irradiated under full shielding (Sham-irradiated); animals receiving whole body irradiation (WBIR); and animals receiving partial body irradiation (PBIR) to the lower abdomen with a 1 x 1 cm2 field. The doses used in the carbon ion group (4.5 Gy) and in argon particle group (1.5 Gy) have a relative biological effectiveness equivalent to a 5 Gy dose of x-rays. 24 hours after irradiation, breast tissues in and out of the irradiated field were harvested for analysis. Induction of COX2, 8-hydroxydeoxyguanosine (8-OHdG), phosphorylated histone H2AX (γ-H2AX), and apoptosis-related cysteine protease-3 (Caspase-3) antibodies were examined in the four categories of breast tissues using immunohistochemical techniques. Analysis was performed by measuring the intensity of more than 20 individual microscopic fields and comparing the relative fold difference.
Results: In the carbon ion group, the relative fold increase in COX2 expression was 1.01 in sham-irradiated group (p > 0.05), 3.07 in PBIR (p 0.05), 11.31 in PBIR (p 0.05), 8.41 in PBIR (p < 0.05) and 10.59 in WBIR (p < 0.05). Results for the argon particle therapy group showed a similar magnitude of changes in the various biological endpoints examined.
There was no statistical significance observed in Caspase-3 expression among the 4 groups.
Conclusions: Our data show that both carbon and argon ions induced non-targeted, out of field induction of COX2 and DNA damages in breast tissues. These effects may pose new challenges to evaluate the risks associated with radiation exposure and understanding radiation-induced side effects
Induction of Non-Targeted Stress Responses in Mammary Tissues by Heavy Ions
No full textPurpose: Side effects related to radiation exposures are based primarily on the assumption that the detrimental effects of radiation occur in directly irradiated cells. However, several studies have reported over the years of radiation-induced non-targeted/ abscopal effects in vivo that challenge this paradigm. There is evidence that Cyclooxygenase-2 (COX2) plays an important role in modulating non-targeted effects, including DNA damages in vitro and mutagenesis in vivo. While most reports on radiation-induced non-targeted response utilize x-rays, there is little information available for heavy ions.
Methods and Materials: Adult female transgenic gpt delta mice were exposed to an equitoxic dose of either carbon or argon particles using the Heavy Ion Medical Accelerator in Chiba (HIMAC) at the National Institute of Radiological Sciences (NIRS) in Japan. The mice were stratified into 4 groups of 5 animals each: Control; animals irradiated under full shielding (Sham-irradiated); animals receiving whole body irradiation (WBIR); and animals receiving partial body irradiation (PBIR) to the lower abdomen with a 1 x 1 cm2 field. The doses used in the carbon ion group (4.5 Gy) and in argon particle group (1.5 Gy) have a relative biological effectiveness equivalent to a 5 Gy dose of x-rays. 24 hours after irradiation, breast tissues in and out of the irradiated field were harvested for analysis. Induction of COX2, 8-hydroxydeoxyguanosine (8-OHdG), phosphorylated histone H2AX (γ-H2AX), and apoptosis-related cysteine protease-3 (Caspase-3) antibodies were examined in the four categories of breast tissues using immunohistochemical techniques. Analysis was performed by measuring the intensity of more than 20 individual microscopic fields and comparing the relative fold difference.
Results: In the carbon ion group, the relative fold increase in COX2 expression was 1.01 in sham-irradiated group (p > 0.05), 3.07 in PBIR (p 0.05), 11.31 in PBIR (p 0.05), 8.41 in PBIR (p < 0.05) and 10.59 in WBIR (p < 0.05). Results for the argon particle therapy group showed a similar magnitude of changes in the various biological endpoints examined.
There was no statistical significance observed in Caspase-3 expression among the 4 groups.
Conclusions: Our data show that both carbon and argon ions induced non-targeted, out of field induction of COX2 and DNA damages in breast tissues. These effects may pose new challenges to evaluate the risks associated with radiation exposure and understanding radiation-induced side effects
shaohu/MGWR: MGWR Python Implementation Release
No full textRelease the Python Implementation of the algorithm for Gradient-based optimization for Multi-scale Geographically Weighted Regression
<ul>
<li>Main Developer Xiaodan Zhou <a href="mailto:[[email protected]](mailto:[email protected])">[[email protected]](mailto:[email protected])</a></li>
<li>Other contributers Hu Shao<a href="mailto:[[email protected]](mailto:[email protected])">[[email protected]](mailto:[email protected])</a>; Cheng-Chia Huang <a href="mailto:[[email protected]](mailto:[email protected])">[[email protected]](mailto:[email protected])</a>;</li>
</ul>
Time's Arrow, December 8, 1995
Full text linkThis is the concert program of the Time's Arrow performance on Friday, December 8, 1995 at 8:00 p.m., at the Tsai Performance Center, 685 Commonwealth Avenue, Boston, Massachusetts. Works performed were Three Songs for Soprano and Chamber Ensemble by Cheng Chia Wu, Octet by Galina Ustvolskaya, Alarums and Excursions by Joyce Mekeel, and Chain I by Witold Lutoslawski. Digitization for Boston University Concert Programs was supported by the Boston University Humanities Library Endowed Fund
Supplementary_Table - The Potential Effect of Different Doses of Ionizing Radiation on Genes and Disease
No full textSupplementary_Table for The Potential Effect of Different Doses of Ionizing Radiation on Genes and Disease by Cheng-Chia Lin, Lawrence Shih-Hsin Wu and Kuei-Fang Lee in Dose-Response</p
Statistical and fuzzy approach for database security
Full text linkA new type of database anomaly is described by
addressing the concept of Cumulated Anomaly in this
paper. Dubiety-Determining Model (DDM), which is a
detection model basing on statistical and fuzzy set
theories for Cumulated Anomaly, is proposed. DDM
can measure the dubiety degree of each database
transaction quantitatively. Software system
architecture to support the DDM for monitoring
database transactions is designed. We also
implemented the system and tested it. Our
experimental results show that the DDM method is
feasible and effective
Measurements and model prediction of the solid–liquid equilibria of organic binary mixtures
No full text- …
