104 research outputs found
Traité de l’historien parfait (Shitong)
No full textOuvrage unique en son genre, car il nous ouvre les portes de l’atelier de l’historien chinois du Moyen Âge, le Traité de l’historien parfait (Shitong) fut composé sous la dynastie des Tang (618‑907) par un professionnel de l’histoire, employé de l’État impérial, le lettré Liu Zhiji (661‑721). Afin de réaliser son traité, à la fois théorique et pratique, l’auteur s’est appuyé sur plus de trois cents textes historiques dont beaucoup ont été depuis perdus.The Generalities on History (Shitong) is a unique work, because it opens the doors to a workshop that belonged to a Chinese historian of the Middle Ages. It was written under the Tang dynasty (618‑907) by a professional historian working for the Imperial State and a member of the literati, Liu Zhiji (661‑721). To write his treatise, which is at the same time theoretical and practical, the author relied on more than three hundred historical texts many of which were subsequently lost
Hierarchical Neurocognitive Model of Externalizing and Internalizing Comorbidity
No full textAbstract Mounting evidence suggests hierarchical psychopathology factors underlying psychiatric comorbidity. However, the exact neurobiological characterizations of these multilevel factors remain elusive. In this study, leveraging the brain-behavior predictive framework with a 10-year longitudinal imaging-genetic cohort (IMAGEN, ages 14, 19 and 23, N = 1,750), we constructed two neural factors underlying externalizing and internalizing symptoms, which were reproducible across six clinical and population-based datasets (ABCD, STRATIFY/ ESTRA, ABIDE II, ADHD-200 and XiNan, from age 10 to age 36, N = 3,765). These two neural factors exhibit distinct neural configurations: hyperconnectivity in impulsivity-related circuits for the externalizing symptoms and hypoconnectivity in goal-directed circuits for the internalizing symptoms. Both factors also differ in their cognitive-behavior relevance, genetic substrates and developmental profiles. Together with previous studies, these findings propose a hierarchical neurocognitive spectral model of comorbid mental illnesses from preadolescence to adulthood: a general neuropsychopathological (NP) factor (manifested as inefficient executive control) and two stratified factors for externalizing (deficient inhibition control) and internalizing (impaired goal-directed function) symptoms, respectively. These holistic insights are crucial for the development of stratified therapeutic interventions for mental disorders
Expanding the genetic spectrum for Chinese familial hypercholesterolemia population with six genetic mutations identified using a next‐generation sequencing‐based laboratory‐developed screening test
No full textAbstract Background This study was to reveal the prevalence of definite familial hypercholesterolemia (FH) in the hospital‐visiting population, determine the pathogenic mutation detection rate in clinically diagnosed definite FH patients, and expand the FH mutation spectrum in China. Methods Blood lipid profiles of 41,803 patients visiting the hospital were investigated and 4967 patients with clinical diagnoses of other metabolic diseases were excluded. One hundred and seventy‐three (0.41%) received a definite diagnosis of FH according to the Dutch Lipid Clinical Network Criteria‐Chinese Revised Version (DLCN‐CRV), and 18 patients subsequently agreed to undergo genetic testing. A next‐generation sequencing (NGS)‐based laboratory‐developed test covering the exonic regions of 24 lipid metabolism‐related genes was conducted alongside in silico analyses to identify possible FH mutations in 16 definite FH patients, according to the American College of Medical Genetics and Genomics (ACMG) criteria. Sanger sequencing was used to confirm mutations, and SWISS‐MODEL was used to simulate the molecular structures of the confirmed protein‐carrying mutations. Results The FH prevalence was 0.41% for the 41,803 individuals (DLCN‐CRV grade >8) and 25% of definite FH patients carried six FH pathogenic mutations (≥ACMG Class 4). All genetic variants were confirmed by Sanger sequencing. Five pathogenic variants on the LDLR gene (NM_000527: c.C1783T: p.R595W, c.T493G: p.W165G, c.G1879A: p.A627T, c.G682T: p.E228X, and exon10: c.G1432A: p.G478R) and one pathogenic variant on APOB (NM_000384: c.C10579T: p.R3527W) in 25% of the identified definite FH patients. Two pathogenic mutations, c.T493G (p.W165G) and c.C1783T (p.R595W), were added to the current genetic spectrum of FH in China. Conclusion This study contributes to improving the current FH detection rate and genetic screening strategies; it provides new directions for treatment, management, and drug development
A shared neural basis underlying psychiatric comorbidity
No full textAbstract Recent studies proposed a general psychopathology factor underlying common comorbidities among psychiatric disorders. However, its neurobiological mechanisms and generalizability remain elusive. In this study, we used a large longitudinal neuroimaging cohort from adolescence to young adulthood (IMAGEN) to define a neuropsychopathological (NP) factor across externalizing and internalizing symptoms using multitask connectomes. We demonstrate that this NP factor might represent a unified, genetically determined, delayed development of the prefrontal cortex that further leads to poor executive function. We also show this NP factor to be reproducible in multiple developmental periods, from preadolescence to early adulthood, and generalizable to the resting-state connectome and clinical samples (the ADHD-200 Sample and the Stratify Project). In conclusion, we identify a reproducible and general neural basis underlying symptoms of multiple mental health disorders, bridging multidimensional evidence from behavioral, neuroimaging and genetic substrates. These findings may help to develop new therapeutic interventions for psychiatric comorbidities
Research on Starbucks marketing strategy and future development means based on 4P model
No full textChina is the largest developing country in the world, which determines that China is a huge potential coffee consumption market, and also determines that China is bound to become a lucky place for Starbucks. This paper for the research object, through the literature method, questionnaire survey, mathematical statistics method to analyze the marketing environment of Starbucks, combined with the analysis of 4P theory, found that the Starbucks product features, high price, offline stores, promotions to attract customers, promotion is not enough. In this regard, Author have proposed the specific characteristics of the product. In terms of improving the service level and price, the market segment is mainly based on customer demand, the channel mainly focuses on communicating with customers and improving the marketing experience, and the promotion mainly focuses on creating response measures in line with consumers. Suitable for the marketing of domestic coffee and beverage industry such as Starbucks
Un historien sur le banc des accusés : Liu Zhiji juge Wei Shou
No full textInternational audienceIn Liu Zhiji's Generalities on History (Shitong 史通), Wei Shou 魏收 (506-572) appears to be the counter-model of the ideal historian. Judged as partial, unfair and servile to the political power that employed him (the Northern Qi), Wei Shou, author of the Book of Wei (Weishu 魏書), is indeed the bugbear of the critic. The article aims to examine the formal and ideological particularities of the Book of Wei, as brought out by Liu Zhiji 劉知幾 (661-721). The numerous comments of Liu Zhiji shows that the question of political legitimity, especially the antagonism Northern states vs Southern states, count for much in his judgements on the historical works of and on the Early Medieval period (220-589).Dans le Traité de l'historien parfait (Shitong 史通) de Liu Zhiji 劉知幾 (661-721), Wei Shou 魏收 (506-572) fait figure de contre-modèle de l'historien idéal. Jugé partial, injuste et servile envers le pouvoir politique qui l'employait, les Qi du Nord, Wei Shou, l'auteur du Livre des Wei (Weishu 魏書), est la véritable bête noire du critique. L'article se propose d'examiner les spécificités formelles et idéologiques du Livre des Wei telles que les a mises en lumière Liu Zhiji. Les multiples commentaires de ce dernier montrent que les questions de légitimité politique, notamment l'antagonisme États du Nord vs États du Sud, pèsent de tout leur poids dans son appréciation des œuvres historiques du haut Moyen Âge (220-589)
Un historien sur le banc des accusés : Liu Zhiji juge Wei Shou
No full textInternational audienceIn Liu Zhiji's Generalities on History (Shitong 史通), Wei Shou 魏收 (506-572) appears to be the counter-model of the ideal historian. Judged as partial, unfair and servile to the political power that employed him (the Northern Qi), Wei Shou, author of the Book of Wei (Weishu 魏書), is indeed the bugbear of the critic. The article aims to examine the formal and ideological particularities of the Book of Wei, as brought out by Liu Zhiji 劉知幾 (661-721). The numerous comments of Liu Zhiji shows that the question of political legitimity, especially the antagonism Northern states vs Southern states, count for much in his judgements on the historical works of and on the Early Medieval period (220-589).Dans le Traité de l'historien parfait (Shitong 史通) de Liu Zhiji 劉知幾 (661-721), Wei Shou 魏收 (506-572) fait figure de contre-modèle de l'historien idéal. Jugé partial, injuste et servile envers le pouvoir politique qui l'employait, les Qi du Nord, Wei Shou, l'auteur du Livre des Wei (Weishu 魏書), est la véritable bête noire du critique. L'article se propose d'examiner les spécificités formelles et idéologiques du Livre des Wei telles que les a mises en lumière Liu Zhiji. Les multiples commentaires de ce dernier montrent que les questions de légitimité politique, notamment l'antagonisme États du Nord vs États du Sud, pèsent de tout leur poids dans son appréciation des œuvres historiques du haut Moyen Âge (220-589)
AV-MaskEnhancer: Enhancing Video Representations through Audio-Visual Masked Autoencoder
No full textLearning high-quality video representation has shown significant applications
in computer vision and remains challenging. Previous work based on mask
autoencoders such as ImageMAE and VideoMAE has proven the effectiveness of
learning representations in images and videos through reconstruction strategy
in the visual modality. However, these models exhibit inherent limitations,
particularly in scenarios where extracting features solely from the visual
modality proves challenging, such as when dealing with low-resolution and
blurry original videos. Based on this, we propose AV-MaskEnhancer for learning
high-quality video representation by combining visual and audio information.
Our approach addresses the challenge by demonstrating the complementary nature
of audio and video features in cross-modality content. Moreover, our result of
the video classification task on the UCF101 dataset outperforms the existing
work and reaches the state-of-the-art, with a top-1 accuracy of 98.8% and a
top-5 accuracy of 99.9%.Comment: 2023 IEEE 35th International Conference on Tools with Artificial
Intelligence (ICTAI
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