384,505 research outputs found
Changes in penicillin-binding proteins during the life cycle of Micromonospora
No full textThe penicillin-binding proteins (PBPs) of Micromonospora were studied. Only one PBP (48,000 mol weight) was found in membranes isolated from primary mycelia, whereas three PBPs were observed in secondary mycelia and designated PBP 1 (89,000 mol weight), PBP2 (69,000) and PBP3 (48,000). Both the unique PBP produced by primary mycelia and PBP3 of secondary mycelia had the same affinity for penicillin which was higher than that of PBP2 and 3. The role of these proteins in the cell life cycle of Micromonospora is discussed
"Closing the R&D Gap, Evaluating the Sources of R&D Spending"
Get PDFBoth spending and tax policies have been implemented in the United States with the goal of stimulating private sector research and development (R&D). Karier questions whether current R&D policy, especially the research and experimentation tax credit, can contribute to closing the gap between nondefense expenditures on R&D in the United States and such expenditures in other countries, such as Japan and Germany. He also explores possible changes to our current R&D policy to make it more effective.
Validity of the Novel Taiwan Lymphoscintigraphy Staging and Correlation of Cheng Lymphedema Grading for Unilateral Extremity Lymphedema
No full textOBJECTIVE: The aim was to validate the new Taiwan Lymphoscintigraphy Staging, correlate it with Cheng Lymphedema Grading (CLG) and evaluate the treatment outcomes of unilateral extremity lymphedema. BACKGROUND: No consensus has been reached for diagnosis and staging for patients with lymphedema among medical specialties. METHODS: We included 285 patients with unilateral extremity lymphedema using lymphoscintigraphy. Lymphoscintigraphy was correlated to clinical symptoms and signs, and classified into normal lymphatic drainage, partial obstruction, and total obstruction. Inter- and intraobserver reliability of Taiwan Lymphoscintigraphy Staging, correlation between Taiwan Lymphoscintigraphy Staging and clinical findings were conducted. Patients were categorized in "surgical" (n = 154) or "nonsurgical" (n = 131) groups for outcome evaluation. RESULTS: Lymphoscintigraphy found 11 patients (3.9%) with normal lymphatic drainage, 128 (44.9%) with partial obstruction, and 146 (51.2%) with total obstruction. Taiwan Lymphoscintigraphy Staging showed high interobserver agreement [intraclass correlation coefficient: 0.89 (95% confidence interval, 0.82-0.94)], and significantly correlated to computed tomography volumetric difference (r = 0.66, P < 0.001) and CLG [intraclass correlation coefficient: 0.79 (95% confidence interval 0.72-0.84)]. At a mean follow-up of 31.2 ± 2.9 months, significant improvement in the circumferential difference (from 23.9% ± 17.6% to 14.6% ± 11.1%; P = 0.03) with a mean circumferential reduction rate of 40.4% ± 4.5% was found in surgical group. At a mean follow-up of 26.6 ± 8.7 months, the nonsurgical group had increase of mean circumferential difference from 24.0% ± 17.2% to 25.3% ± 19.0% (P = 0.09), with a mean circumferential reduction rate was -1.9% ± 13.0%. CONCLUSIONS: The Taiwan Lymphoscintigraphy Staging is a reliable diagnostic tool, correlated with clinical findings and CLG, aiding in the selection of the appropriate treatment to achieve favorable long-term outcomes in unilateral extremity lymphedema
El vestido habla: Alice Munro y Kai Cheng Thong
No full textEl objetivo del presente artículo es estudiar los diversos códigos atribuidos a la indumentaria en el corpus literario seleccionado a tal efecto y analizar cómo las identidades de los personajes son rediseñadas a través de ellos. Examinaremos cómo los sujetos de las obras de las autoras canadienses Alice Munro y Kai Cheng Thom hacen uso de la indumentaria como herramienta a través de la cual se ajustan a las normas impuestas o, por el contrario, subvierten los discursos hegemónicos
Endosymbiotic copepods may feed on zooxanthellae from their coral host, Pocillopora damicornis
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