59 research outputs found
The role of junctional adhesion molecule JAM1a during hemogenic endothelial cell specification in zebrafish embryos
No full textHemogenic endothelial cells (HECs) refer to the endothelial cells that have the potential to become hematopoietic stem cells/ progenitor cells that can undergo a cell behavior called endothelial hematopoietic transition (EHT) in zebrafish. The budding HSPCs from the aorta later will differentiate into multiple blood lineages and continuously replenish hematopoietic system. It is of great importance to understand the fate commitment and development of the HECs. However, the complex mechanism determining the HECs and conventional endothelial cells (ECs) fate has never been delineated very clearly. So far, we know that etv2-notch signaling axis is essential for the HECs fate commitment and my research aims to perfect this network. Jam1a is a cell-cell adhesion molecule that are expressed in endothelial cells, epithelial cells and pronephros in zebrafish. A study indicated the role of jam1a in HECs specification. It suggested that the jam1a provide close interactions to another JAM family member on somitic cells, making the cell accessible to the notch ligand therefore cells with activated notch signaling can be committed into HECs. In my study, I further prove that jam1a is indispensable for HECs formation due to runx1 expression level decrease in both jam1a morphant and mutant. However, it remains unclear if jam1a take part in the HECs regulation in other way expect for its intrinsic feature as an adhesion molecule. Some studies indicate that jam1a may also be regulated by etv2. Therefore, more investigations should be conducted exploring the relationship between etv2 and jam1a.</p
道枢论(Daoshulun)-The theory of the Pivot of the Dao
No full textThis paper proposes The theory of the Pivot of the Dao (Daoshulun,DSL), aiming to investigate certain issues through the lens of recursivity and non-recursivity. The paper is divided into two main sections:
The first section systematically expounds the theoretical foundation of the D-P framework, defining the dialectical relationship between recursivity (P) and non-recursivity (D). Through five core propositions, DSL asserts that the essence of hierarchical evolution lies in the eternal game of recursive chains.
The second section explores DSL’s division of rationality, the ethics of artificial intelligence (AI) under DSL, and an interpretation of the latent laws governing scientific development.
The D-P framework offers a unified explanation for the hierarchical interactions, limitations, and evolutionary patterns of complex systems. Its methodological discussions encompass AI ethics, philosophy of science, and social governance.
© 蒋柯帆 2025. This is a preprint version licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). This version supersedes all previous versions uploaded prior to March 13, 2025, which did not carry an explicit license. You are free to share and adapt this material for non-commercial purposes, provided you give appropriate credit to the author. For commercial use, please contact the author.
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考虑室内呼吸暴露风险的人群引流控制策略研究
No full textIn order to explore impacts of crowd intervention strategies on indoor respiratory exposure risks during major pandemics, a variety of crowd motion scenarios were established in general indoor conditions based on improved pedestrian dynamics model and respiratory infection probability model. Then, multi-agent simulation technology was utilized to simulate impacts of strategies, including protection optimization, pedestrian flow optimization and route optimization, on the exposure risks. The results show that indoor respiratory exposure risks are mainly determined by total pedestrian flow, individuals’ stay length, movement route planning and duration of stay in contaminated areas. The carryover effect will be formed due to pedestrians’ obedience behavior of social distancing, which will further increase exposure time to contaminated areas. The lower pathogen permeability of masks, and the greater space ventilation are, the lower infection probability the crowd will face.System Engineerin
An Adversarial Machine Learning Method Based on OpCode N-grams Feature in Malware Detection
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Three-dimensional reconstruction-guided modified arterial-based complexity scoring system for nephron-sparing surgery: comparative outcomes of on-clamp and off-clamp tumor enucleation in renal cell carcinoma
No full textBackgroundVarious modalities of nephron-sparing surgery (NSS) exist; however, a comprehensive standard for determining the most suitable approach for specific kidney cancer patients remains elusive. This study aims to establish a novel scoring system that will assist urologists in formulating tailored surgical plans.MethodsWe conducted a comparative assessment of perioperative and prognostic data for these surgical types, alongside tumor contact surface area and arterial-based complexity of 205 patients for classification and regression analysis. Finally, a modified arterial-based complexity (mABC) scoring system was developed to enhance this assessment methodology.ResultsDespite no statistical differences in demographic data, we found that the off-clamp tumor enucleation (TE) group experienced greater estimated blood loss, drainage, catheterization, and longer hospital stays compared to the other two groups. However, this group also had shorter surgical times and less kidney function impairment, particularly in patients with renal dysfunction. Subgroup analysis indicated that when the mABC score was ≥4, patients in the off-clamp TE group showed significant increases in the rate of reduction in eGFR, blood loss, postoperative complications, postoperative drainage volume, and postoperative hospital days compared to patients in the other two groups.ConclusionsThe findings indicate that patients with fewer challenges in renal surgery may benefit from off-clamp TE, while those facing greater difficulty may find on-clamp TE more appropriate. This distinction, based on mABC scoring criteria, emphasizes the importance of tailoring the surgical approach to individual patient needs.Trial RegistrationOur study has been approved by the Ethics Committee of The Fourth Affiliated Hospital of Zhejiang University School of Medicine (K2023003) on 10/02/2023 and by clinical trials (NCT05790122) on 27/03/2023
The High-Strain-Rate Impacts Behaviors of Bilayer TC4-(GNPs/TC4) Composites with a Hierarchical Microstructure
No full textTi matrix composites (TMCs) are promising structural materials that meet the increasing demands for light weight the automobile and aircraft industries. However, the room temperature brittleness in the traditionally homogeneous reinforcement distribution of TMCs limits their application in high-strain-rate impact environments. In the present study, novel bilayer TMCs with hierarchical microstructures were designed by the laminated combination of graphene nanoplatelet (GNPs) reinforced TC4 (Ti-6Al-4V) composites (GNPs/TC4) and a monolithic TC4. Meanwhile, the configuration of the microstructure, impact performance V50, and deformation modes of the bilayered TC4-(GNPs/TC4) plate was investigated. The plates were fabricated via field-assisted sintering technology (FAST). It turned out that the TC4-(GNPs/TC4) plate with a 7.5 mm thickness against a 7.62 mm projectile exhibited greater impact performance (V50~825 m/s) compared to the TC4 and GNPs/TC4 single-layer plates. The plate failure modes were dependent on the microstructure while the failure behaviors seemed to be influenced by the hierarchical configuration. This work provided a new strategy for utilizing TMCs in the field of high-strain-rate impact environments
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