751,954 research outputs found
Edward C. M. Chen, oral history interview and transcript
No full textThis recording and transcript form part of a collection of oral history interviews conducted by the Chao Center for Asian Studies at Rice University. This collection includes audio recordings and transcripts of interviews with Asian Americans native to Houston.Edward C. M. Chen, interviewed by Juean Chen and Clarissa Cox, June 4, 2010, in Houston, Texas
Jingyi-Chen/cloud_parcel_mode: cloud parcel model
No full textThis is the first release of the cloud parcel model developed by Jingyi Chen. The development of this model was supported by Stony Brook University and Brookhaven National Laboratory in 2012-2014 (adiabatic version) and 2015-2017 (entrainment-mixing with entrained aerosols).
The publications associated with this code is below:
Chen, J., Y. Liu, M. Zhang, and Y. Peng (2016), New understanding and quantification of the regime dependence of aerosol-cloud interaction for studying aerosol indirect effects, Geophysical Research Letter, 43, 1780–1787, doi:10.1002/2016GL067683.
Chen, J., Y. Liu, M. Zhang, and Y. Peng (2018), Height dependency of aerosol-cloud interaction regimes, Journal of Geophysical Research: Atmospheres, doi: 10.1002/2017JD027431.
Chen, J., Y. Liu and M. Zhang (2020), Effects of Lateral Entrainment-Mixing with Entrained Aerosols on Cloud Microphysics, Geophysical Research Letter, doi: 10.1029/2020GL087667
Participation of c-FLIP in NLRP3 and AIM2 inflammasome activation
No full textCellular FLICE-inhibitory protein (c-FLIP) is an inhibitor of caspase-8 and is required for macrophage survival. Recent studies have revealed a selective role of caspase-8 in noncanonical IL-1 beta production that is independent of caspase-1 or inflammasome. Here we demonstrated that c-FLIPL is an unexpected contributor to canonical inflammasome activation for the generation of caspase-1 and active IL-1 beta. Hemizygotic deletion of c-FLIP impaired ATP-and monosodium uric acid (MSU)-induced IL-1 beta production in macrophages primed through Toll-like receptors (TLRs). Decreased IL-1 beta expression was attributed to a reduced activation of caspase-1 in c-FLIP hemizygotic cells. In contrast, the production of TNF-alpha was not affected by downregulation in c-FLIP. c-FLIPL interacted with NLRP3 or procaspase-1. c-FLIP is required for the full NLRP3 inflammasome assembly and NLRP3 mitochondrial localization, and c-FLIP is associated with NLRP3 inflammasome. c-FLIP downregulation also reduced AIM2 inflammasome activation. In contrast, c-FLIP inhibited SMAC mimetic-, FasL-, or Dectin-1-induced IL-1 beta generation that is caspase-8-mediated. Our results demonstrate a prominent role of c-FLIPL in the optimal activation of the NLRP3 and AIM2 inflammasomes, and suggest that c-FLIP could be a valid target for treatment of inflammatory diseases caused by over-activation of inflammasomes
Enhancement of random lasing based on the composite consisting of nanospheres embedded in nanorods template
No full textC. C. Chen, 1918
No full textC. C. Chen, first Chinese student to attend the University of Maryland, 1918
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