130 research outputs found
A three-stage sequential surgical approach to a more efficient management of clinical stage 4 diabetic foot ulcers
No full textBackground:It has been a great challenge to treat clinical stage 4 Diabetic foot
ulcers (DFUs) due to high rates of major amputations and prolonged healing
time. This study aimed to assess the effectiveness of a three-stage sequential
surgical approach, which based on the Integrated Surgery Wound Treatment
(ISWT) mode, to manage clinical stage 4 DFUs and compare the benefit of
incorporating tibial cortex transverse transport (TTT) surgery at stage
3 treatment.
Methods: Twenty-three patients with clinical stage 4 DFUs aged 45–75 years
treated between January 2022 and February 2023 were retrospectively
analyzed. Eleven patients (Group A) received wound debridement, antibiotic-
loaded bone cement (ALBC) at stage 1 treatment, percutaneous transluminal
angioplasty (PTA), wound debridement, and ALBC at stage 2 treatment, and
skin grafting with TTT at stage 3 treatment, while twelve patients (Group B)
received the same treatment without TTT. Assessed clinical outcomes
included length of hospital stay, ulcer healing duration, ulcer recurrence rate,
reintervention (re)-PTA rate, amputation rate, mortality rate, visual analog
scale (VAS) scores, ankle-brachial index (ABI), and two-point discrimination
(2-PD) ability. The computed tomographic angiography (CTA) was used to
evaluate vascular hyperplasia.
Results: Group A showed no occurrences of re-PTA ( = 0.037) and similar
ulcer healing times ( = 0.975) compared to Group B. Ulcer outcome,
amputation, and mortality rate were also alike in the two groups ( > 0.05).
One year after surgery, Group A demonstrated improvement in VAS scores,
ABI, and 2-PD, while Group B showed no significant changes. Additionally,
Group A exhibited enhanced lower limb artery characteristics compared to
Group B.
Conclusion: The sequential three-stage approach based on the ISWT mode
effectively manages clinical stage 4 DFUs. Incorporating TTT surgery at stage
3 extends the benefits of PTA surgery
First-principles prediction of the native filament:dielectric interfaces for the possible filamentary switching mechanism in chalcogenide selector devices
No full textShape and Diffusion of Circular Polyelectrolytes in Salt-Free Dilute Solutions and Comparison with Linear Polyelectrolytes
No full textReview on Heat Generation of Rubber Composites
No full textRubber composites are extensively used in industrial applications for their exceptional elasticity. The fatigue temperature rise occurs during operation, resulting in a serious decline in performance. Reducing heat generation of the composites during cyclic loading will help to avoid substantial overheating that most likely results in the degradation of materials. Herein, we discuss the two main reasons for heat generation, including viscoelasticity and friction. Influencing factors of heat generation are highlighted, including the Payne effect, Mullins effect, interface interaction, crosslink density, bond rubber content, and fillers. Besides, theoretical models to predict the temperature rise are also analyzed. This work provides a promising way to achieve advanced rubber composites with high performance in the future
A recycled environmental friendly flame retardant by modifying para-aramid fiber with phosphorus acid for thermoplastic polyurethane elastomer
No full textReply to Kelder et al.: Does the Dorsal Mesenchymal Protrusion Act as a Temporary Pacemaker during Heart Development?
No full textA statistical study of proton conduction in Nafion®-based composite membranes: Prediction, filler selection and fabrication methods
No full text<i>para</i>-Aramid fiber modified by melamine polyphosphate and its flame retardancy on thermoplastic polyurethane elastomer
No full textWith the increasing applications of thermoplastic polyurethane elastomer (TPU), the fire risk and smoke hazard caused by TPU have aroused wide attention.</p
Effects of Chain Stiffness on Conformational and Dynamical Properties of Individual Ring Polymers in Shear Flow
No full textSerum Level of Fibroblast Growth Factor 21 Is Independently Associated with Acute Myocardial Infarction.
No full textFibroblast growth factor 21 (FGF21) has been described as a metabolic hormone critical for glucose and lipid metabolism. Previously, high levels of FGF21 were observed in patients with coronary heart disease and non-acute myocardial infarction (non-AMI). In this study, we investigated the changes in FGF21 levels in Chinese patients with AMI.We used ELISA to measure circulating FGF21 levels in 55 AMI patients and 45 non-AMI control patients on the 1st day after syndrome onset. All patients were followed-up within 30 days. FGF21 levels in AMI patients were significantly higher than those in non-AMI controls (0.25 (0.16-0.34) vs. 0.14 (0.11-0.20) ng/mL, P < 0.001). FGF21 levels reached the maximum within approximately 24 h after the onset of AMI and remained at high for 7 days, and the FGF21 level (OR: 16.93; 95% confidence interval (CI): 2.65-108.05; P = 0.003) was identified as an independent factor associated with the presence of AMI. On the 7th day, FGF21 levels were significantly higher in the patients who subsequently developed re-infarction within 30 days than in the patients who did not develop re-infarction (with vs. without re-infarction: 0.45 (0.22-0.64) vs. 0.21 (0.15-0.29) ng/mL, P = 0.014).The level of serum FGF21 is independently associated with the presence of AMI in Chinese patients. High FGF21 levels might be related to the incidence of re-infarction within 30 days after onset
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