771 research outputs found
Magnetic field effects on T-c and the pseudogap onset temperature in cuprate superconductors
No full textPair excitations, collective modes, and gauge invariance in the BCS-Bose-Einstein crossover scenario
No full textA precursor superconductivity approach to the magnetic field effects in the pseudogap phase
No full textMagnetic-field effects in the pseudogap phase: A competing energy gap scenario for precursor superconductivity
No full textIncreased serum high-mobility group box-1 and cleaved receptor for advanced glycation endproducts levels and decreased endogenous secretory receptor for advanced glycation endproducts levels in diabetic and non-diabetic patients with heart failure
No full textAims: High-mobility group box-1 (HMGB1) is a ligand for the receptor for advanced glycation endproducts (RAGE). An
HMGB1–RAGE interaction has been implicated in cardiac dysfunction. We assessed the association of HMGB1
and RAGE isoforms with heart failure (HF) in diabetic and non-diabetic patients.
Methods and results:
We assayed serum levels of HMGB1, cleaved RAGE (cRAGE), endogenous secretory RAGE (esRAGE), high-sensitivity
C-reactive protein (hsCRP), and N-terminal pro-brain natriuretic peptide (NT-proBNP) in parallel with assessment
of left ventricular volumes and function in 125 diabetic and 222 non-diabetic Chinese patients with chronic HF.
Of the total, 79 diabetic patients without HF and 220 normal subjects served as diabetic and normal controls,
respectively. Serum HMGB1, cRAGE, hsCRP, and NT-proBNP levels were higher and, in contrast, esRAGE levels
lower in HF patients than in subjects without HF (for all; P , 0.01), with higher levels of cRAGE and hsCRP in diabetic
HF vs. non-diabetic HF patients (P , 0.01). For HF patients—with or without diabetes—HMGB1 levels correlated
positively with left ventricular end-diastolic and end-systolic volumes (r 1⁄4 0.267 and r 1⁄4 0.321, respectively) and
NT-proBNP values (r 1⁄4 0.497), and were inversely related to ejection fraction (r 1⁄4 20.461; all P , 0.001). Serum
cRAGE levels correlated with NT-proBNP values (r 1⁄4 0.451) and New York Heart Association functional class
(r 1⁄4 0.402; both P , 0.001). Multivariable regression analysis revealed that HMGB1, cRAGE, and esRAGE were consistently
associated with HF in diabetic and non-diabetic patients.
Conclusion: Heart failure patients have increased serum HMGB1 and cRAGE and decreased esRAGE levels, and these are related
to the severity of HF in both diabetic and non-diabetic patients. Such associations are worth further investigation
The origin of the pseudogap phase: precursor superconductivity versus a competing energy gap scenario
No full textPARALLEL EXISTENCE OF EPSTEIN-BARR-VIRUS (EBV) POSITIVE AND NEGATIVE CELLS IN A SPORADIC CASE OF BURKITT-LYMPHOMA
No full textStatistical Testing of Optimality Conditions in Multiresponse Simulation-Based Optimization (Replaced by Discussion Paper 2007-45)
Full text linkThis paper derives a novel procedure for testing the Karush-Kuhn-Tucker (KKT) first-order optimality conditions in models with multiple random responses.Such models arise in simulation-based optimization with multivariate outputs.This paper focuses on expensive simulations, which have small sample sizes.The paper estimates the gradients (in the KKT conditions) through low-order polynomials, fitted locally.These polynomials are estimated using Ordinary Least Squares (OLS), which also enables estimation of the variability of the estimated gradients.Using these OLS results, the paper applies the bootstrap (resampling) method to test the KKT conditions.Furthermore, it applies the classic Student t test to check whether the simulation outputs are feasible, and whether any constraints are binding.The paper applies the new procedure to both a synthetic example and an inventory simulation; the empirical results are encouraging.stopping rule;metaheuristics;RSM;design of experiments
Characteristics of colliding sea breeze gravity current fronts: a laboratory study
Full text linkAuthor Posting. © The Author(s), 2017. This is the author's version of the work. It is posted here under a nonexclusive, irrevocable, paid-up, worldwide license granted to WHOI. It is made available for personal use, not for redistribution. The definitive version was published in Quarterly Journal of the Royal Meteorological Society 143 (2017): 1434–1441, doi:10.1002/qj.3015.Sea and land breeze circulations driven by surface temperature differences between
land and sea often evolve into gravity currents with sharp fronts. Along narrow
peninsulas, islands and enclosed seas, sea/land breeze fronts from opposing shorelines
may converge and collide and may initiate deep convection and heavy precipitation.
Here we investigate the collision of two sea breeze gravity current fronts in an
analogue laboratory setting. We examine these collisions by means of ‘lock-exchange’
experiments in a rectangular channel. The effects of differences in gravity current
density and height are studied. Upon collision, a sharp front separating the two currents
develops. For symmetric collisions (the same current densities and heights) this front is
vertical and stationary. For asymmetric collisions (density differences, similar heights)
the front is tilted, changes shape in time and propagates in the same direction as the
heavier current before the collision. Both symmetric and asymmetric collisions lead to
upward displacement of fluid from the gravity currents and mixing along the plane
of contact. The amount of mixing along the collision front decreases with asymmetry.
Height differences impact post-collision horizontal propagation: there is significant
propagation in the same direction as the higher current before collision, independent
of density differences. Collisions of two gravity current fronts force sustained ascending
motions which increase the potential for deep convection. From our experiments we
conclude that this potential is larger in stationary collision fronts from symmetric
sea breeze collisions than in propagating collision fronts from asymmetric sea breeze
collisions.National Science Foundation Grant Number: OCE-0824636;
Office of Naval Research Grant Number: N00014-09-1-0844;
National Aeronautics and Space Administration Grant Number: NASA NNX14A078
A Dominant Dissociation Mode of cis-Dichloroethylene on Si(100)2 x 1: Adjacent Si Dimer Double Dechlorination
No full text- …
