12,946 research outputs found
100W fiberised linearly-polarized picosecond ytterbium doped fiber MOPA
Full text linkWe report a PM, fully-fiberised, picosecond fiber MOPA delivering 20 ps pulses at repetition rates up to 970 MHz and at average powers of up to 100 W
100W single mode single polarization picosecond ytterbium doped fibre MOPA frequency doubled to 530nm
No full textHigh average power laser sources operating in the picosecond (ps) regime are useful for a wide range of applications including frequency-doubling and pumping of OPOs. Gain switching (GS) of laser diodes provides a practical and low cost method to generate ps pulses at GHz repetition rates and mW average power levels. Such devices represent excellent seeds for high power fiber MOPAs allowing power scaling to the 100W regime and we recently reported average powers in excess of 300W from a 1060nm gain-switched FP laser seeded ytterbium doped fiber amplifier (YDFA) MOPA [1, 2]. However this system incorporated free space pump and signal coupling - greatly compromising the practicality of the system. Moreover, the output polarization was ill-defined limiting the utility of the system for many frequency conversion applications. Herein we present a fiberised, diode-seeded, YDFA MOPA system generating linearly polarized, diffraction-limited, 20ps pulses at repetition rates ranging from 113.5 MHz to 908 MHz and at average output powers in excess of 100W. This system represents a considerable improvement in practicality and performance relative to previous high power, fiber-based ps pulse sources [3]. The output of the MOPA was launched into an LBO crystal to generate 45W of green light
Wavelength tunable 10-GHz 3-ps pulse source using a dispersion decreasing fiber-based nonlinear optical loop mirror
Full text linkWe experimentally demonstrate the use of a dispersion decreasing fiber (DDF)-based nonlinear optical loop mirror (NOLM) for the generation of wavelength tunable soliton-like pulses at a repetition rate of 10 GHz. We compress ~12 ps Gaussian pulses from an electro-absorption modulator (EAM) (followed by 125 m of DCF for preliminary linear dispersion compensation) into 3 ps pedestal-free pulses using both high-order soliton compression and nonlinear switching effects within an 8.5 km DDF-based loop mirror. The output pulses from the DDF-based NOLM show considerable pedestal reduction compared to those obtained by directly compressing the EAM seed pulses via a single passage through the DDF. Wavelength tuning of the compressed pulses over a ~15 nm bandwidth (from 1541 to 1556 nm) is demonstrated without a significant increase in pulse duration or degradation in pulse quality
Effect of insulating-nanoparticles addition on ion current and voltage-holding ratio in nematic liquid crystal cells
No full textObservation on pathogenicity and epizootiology of Penaeus-monodon baculovirus (MBV) in cultured shrimp in Taiwan.
No full textAnti-PS IgG Immune Complexes Impair Macrophage Phagocytosis in SLE via LOX-Dependent Oxidative Stress
Full text linkHui Guan,1– 3,* Liqi Huang,1,* Yu Liu,1,* Enyi Zhu,4 Lefeng Chen,5 Weijie Li,2 Haiqi Wu,2 Xiaoying Zhang,6 Rencai Qin,2 Jingpeng Zheng,2 Yingqian Mo,5 Ming Zhong,1 Bihua Xu,7 Xiaoyan Dai,8 Qi Wei,2 Yunwei Chen,2 Qingwen Wang,7 Zhihua Zheng,1 Kongyang Ma,2 Chun Tang1 1Department of Nephrology, Center of Kidney and Urology, the Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, 518107, People’s Republic of China; 2Centre for Infection and Immunity Studies, School of Medicine, The Sun Yat-sen University, Shenzhen, 518107, People’s Republic of China; 3Department of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, People’s Republic of China; 4The Division of Nephrology, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangzhou, 510000, People’s Republic of China; 5Department of Rheumatology, Sun Yat-sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, 510120, People’s Republic of China; 6Health Management Center, the Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, 518107, People’s Republic of China; 7Department of Rheumatology and Immunology, Peking University Shenzhen Hospital, Shenzhen, 518036, People’s Republic of China; 8Clinical Research Institute, Hengyang Medical School, the second Affiliated Hospital, University of South China, Hengyang, 421002, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chun Tang, Email [email protected] Kongyang Ma, Email [email protected]: Systemic lupus erythematosus (SLE) is a severe autoimmune disease with systemic complications mediated by immune-complex formation. The elevated level of anti-phosphatidylserine (PS) IgG has been implicated in SLE pathogenesis. In this study, we aimed to explore the effector mechanisms of PS immune-complex during lupus development.Patients and Methods: Serological profiles of immune-complexes in SLE patients were analyzed. Immunofluorescence staining showed PS-IgG immune-complex deposition in kidney biopsies of lupus nephritis patients. C57BL/6J mice were immunized with PS for immune-complex and renal function assessment. The roles of PS-IgG immune-complex and lysyl oxidase (LOX) were validated from SLE PBMCs, THP-1 cell line and PS-immunized lupus mice. The intracellular reactive oxygen species (ROS) levels, and phagocytosis function were examined by flow cytometry in SLE PBMCs, THP-1 cell line and PS-immunized lupus mice. For in vitro treatment, the effects of antioxidant N-acetylcysteine (NAC) and LOX inhibitor β-Aminopropionitrile (BAPN) were verified in THP-1 cell line and cells from PS-immunized lupus mice.Results: SLE and lupus nephritis (LN) patients showed significant elevated circulating and glomerular PS-IgG immune-complex levels. ROC analysis indicated PS-IgG immune-complex as a strong biomarker in SLE and LN. Mechanistically, induced macrophages from SLE patients treated with PS-IgG immune-complex significantly increased cytoplasmic ROS levels, elevated LOX expression and exhibited dampened phagocytotic function. In mice, PS immunization triggered PS-IgG immune complex formation, increased LOX expression, immune-complex deposited glomerular nephritis, and impaired phagocytotic function of macrophages. NAC and BAPN treatment restored the phagocytotic function of human and murine macrophages.Conclusion: Our results indicate that PS-IgG immune-complex can directly impair macrophage phagocytotic functions via LOX mediated-oxidative stress and may serve as a novel biomarker for SLE.Keywords: systemic lupus erythematosus, anti-phospholipid antibodies, immune complex, macrophage
Further evidence for expression and function of the VEGF-C/VEGFR-3 axis in cancer cells.
No full textEffects of electromyography biofeedback-assisted relaxation on pain in patients with advanced cancer in a palliative care unit.
No full textPurification and biochemical characteristics of occlusion body of Penaeus-monodon-type baculovirus (MBV).
No full textBlind joint maximum likelihood channel estimation and data detection for single-input multiple-output systems
No full textA blind adaptive scheme is proposed for joint maximum likelihood (ML) channel estimation and data detection of single-input multiple-output (SIMO) systems. The joint ML optimization of the channel and data estimation is decomposed into an iterative optimization loop. An efficient global optimization algorithm termed as the repeated weighted boosting aided search is employed first to identify the unknown SIMO channel model, and then the Viterbi algorithm is used for the maximum likelihood sequence estimation of the unknown data sequence. A simulation example is used for demonstrating the efficiency of this joint ML optimization scheme designed for blind adaptive SIMO systems
- …
