1,723,261 research outputs found
Petrology and genesis of cognate plutonic inclusions in andesites of East Coastal Range, Lutao and Lanhsu, Taiwan
No full textMineral compositions of primary phases in ultramafic rocks in the Coastal Range, eastern Taiwan: implication of source regions of these rocks
No full textThe coatomer protein beta'-COP, a selective binding protein (RACK) for protein kinase Cepsilon
No full textDistinct subcellular localization of activated protein kinase C (PKC) isozymes is mediated by their binding to isozyme-specific RACKs (receptors for activated C-kinase). Our laboratory has previously isolated one such protein, RACK1, and demonstrated that this protein displays specificity for PKCbeta. We have recently shown that at least part of the PKCepsilon RACK-binding site on PKCepsilon lies within the unique V1 region of this isozyme (Johnson, J. A., Gray, M. O., Chen, C.-H., and Mochly-Rosen, D. (1996) J. Biol. Chem. 271, 24962-24966). Here, we have used the PKCepsilon V1 region to clone a PKCepsilon-selective RACK, which was identified as the COPI coatomer protein, beta'-COP. Similar to RACK1, beta'-COP contains seven repeats of the WD40 motif and fulfills the criteria previously established for RACKs. Activated PKCepsilon colocalizes with beta'-COP in cardiac myocytes and binds to Golgi membranes in a beta'-COP-dependent manner. A role for PKC in control of secretion has been previously suggested, but this is the first report of direct protein/protein interaction of PKCepsilon with a protein involved in vesicular trafficking
Petrology and geochemistry of Neogene continental basalts and related rocks in Taiwan(II) Teschenites from Luku area
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