62 research outputs found
Chen wai xia ju jian
No full text[v.1]. 總目 -- [v.2- 3]. 卷一至二. 清修妙論牋 : [二卷] -- [v.4-7 ]. 卷三至六. 四時調攝牋 : [四卷] -- [v.8-9 ]. 卷七至八. 起居安樂牋 : [二卷] -- [v.10-11 ]. 卷九至十. 延年却病牋 : [二卷] -- [v.12- 14]. 卷十一至十三. 飲饌服食牋 : [三卷] -- [v.15-17]. 卷十四至十六. 燕閑清賞牋 : [三卷] -- [v.18-19]. 卷十七至十八. 靈秘丹藥牋 : [二卷] -- [v.20]. 卷十九. 塵外遐舉牋.[v.1]. Zong mu -- [v.2- 3]. juan yi zhi er. Qing xiu miao lun jian : [er juan] -- [v.4-7 ]. juan san zhi liu. Si shi diao she jian : [si juan] -- [v.8-9 ]. juan qi zhi ba. Qi ju an yue jian : [er juan] -- [v.10-11 ]. juan jiu zhi shi. Yan nian que bing jian : [er juan] -- [v.12- 14]. juan shi yi zhi shi san. Yin zhuan fu shi jian : [san juan] -- [v.15-17]. juan shi si zhi shi liu. Yan xian qing shang jian : [san juan] -- [v.18-19]. juan shi qi zhi shi ba. Ling mi dan yao jian : [er juan] -- [v.20]. juan shi jiu. Chen wai xia ju jian.[高濂編] ; 鍾惺較閱.綫裝, 2函.框20.3x12.2公分, 9行18字. 白口, 四周黑邊, 單黑魚尾. 版心上鐫"遵生八牋", 中鐫卷次及子目題, 下鐫葉次.内封頁題"增補遵生八牋, 鍾伯敬先生重訂, 課花書屋藏板"前有高濓原序.《燕閑清賞牋》卷端題下鐫"古杭高濂深甫氏編次"《清修妙論牋》, 《起居安樂牋》, 《延年却病牋》, 《靈秘丹藥牋》分上, 下卷 ; 《飲饌服食牋》, 《燕閑清賞牋》分上, 中, 下卷 ; 《四時調攝牋》分春, 下[即"夏"], 秋, 冬卷.見《香港中文大學圖書館古籍善本書錄》(2001, p. 139)Xian zhuang, 2 han.Kuang 20.3 x 12.2 gong fen, 9 hang 18 zi. Bai kou, si zhou hei bian, dan hei yu wei. Ban xin shang juan "Zun sheng ba jian", zhong juan juan ci ji zi mu ti, xia juan ye ci.Nei feng ye ti "Zeng bu zun sheng ba jian, Zhong Bojing xian sheng chong ding, Ke hua shu wu cang ban"Qian you Gao Lian yuan xu."Yan xian qing shang jian" juan duan ti xia juan "Guhang Gao Lian shen fu shi bian ci""Qing xiu miao lun jian", "Qi ju an yue jian", "Yan nian que bing jian", "Ling mi dan yao jian" fen shang, xia juan ; "Yin zhuan fu shi jian", "Yan xian qing shang jian" fen shang, zhong, xia juan ; "Si shi diao she jian" fen Chun, xia [ji "Xia"], Qiu, Dong juan.Jian "Xianggang Zhong wen da xue tu shu guan gu ji shan ben shu lu" (2001, p. 139)[Gao Lian bian] ; Zhong Xing jiao yue
Parkinson’s disease etiology : beyond the brain and late adulthood
No full textDespite much effort investigating the etiology of Parkinson’s disease (PD), the causes and the exact mechanisms underlying the disease remain elusive. Braak’s hypothesis suggests that PD pathology may start in the enteric nervous system and later spread to the brain via the vagus nerve. This hypothesis is further extended to the dual-hit hypothesis suggesting that environmental neurotropic pathogens may contribute to PD development through nasal and gut gateways that are in direct connection with each other via inhalation and ingestion. Mounting evidence also suggests the importance of neuroinflammation in the pathogenesis of PD. In this thesis, I aimed to explore the etiology of PD focusing on developmental origins related to early infection and inflammation, gastrointestinal aspects, and olfactory function using various register and population based datasets.In Study I, we conducted a cohort study to examine developmental aspects of PD regarding early life infection, parental age at birth, multiple birth. We considered birth order, sibship size, birth seasonality, and flu activity in the year of birth as surrogates for early infection and inflammation. Overall, we found that early life characteristics were not associated with future risk of PD, indicating little support for the importance of early life aspects in PD etiology.In Study II, we evaluated vagotomy and its subtypes (truncal and selective vagotomies) in relation to PD risk in a matched cohort. We found that truncal vagotomy, with the nerve trunk fully resected, appeared to be associated with a decreased risk of PD more than five years after the surgery, while selective vagotomy was not associated with the risk of PD. The results provide preliminary evidence supporting Braak’s hypothesis.In Study III, we conducted a nested case-control study in the Swedish total population and a cohort study in Swedish twins to investigate irritable bowel syndrome (IBS) diagnosis as well as IBS based on self-reported symptoms in relation to the risk of PD. The results demonstrated that IBS was linked to an elevated risk of PD. The findings add additional evidence suggesting the importance of gut-brain-axis in PD development.In Study IV, we examined whether poor olfaction is associated with long-term mortality and potential explanations for such association among older adults in a community-based cohort. We found that poor olfaction was associated with higher long-term mortality and that part of the association was explained by neurodegenerative diseases, in particular, PD and dementia, and body weight loss.In summary, by taking advantage of Swedish nationwide registers, we provide some evidence supporting Braak’s hypothesis and the importance of the gut-to-brain axis in PD development. Our data, however, do not support the importance of developmental origins of PD. Additionally, we confirmed the association between poor olfaction and mortality in healthy older adults from the Health, Aging and Body Composition study and identified PD or dementia and body weight loss as part of the potential mechanisms underlying the association.List of scientific papersI. Liu B, Chen H, Fang F, Tillander A,Wirdefeldt K. Early-Life Factors and Risk of Parkinson’s Disease: A Register-Based Cohort Study. PLoS ONE. 2016;11(4). https://doi.org/10.1371/journal.pone.0152841 II. Liu B, Fang F, Pedersen NL, Tillander A, Ludvigsson JF, Ekbom A, Svenningsson P, Chen H, Wirdefeldt K. Vagotomy and Parkinson disease: a Swedish register-based matched-cohort study. Neurology. 2017; 88: 1996-2002. https://doi.org/10.1212/WNL.0000000000003961 III. Liu B, Sjölander A, Pedersen NL, Ludvigsson JF, Chen H, Fang F, Wirdefeldt K. Irritable Bowel Syndrome and Parkinson’s Disease Risk: A Swedish Register-based Study. [Manuscript]IV. Liu B, Luo Z, Pinto JM, Shiroma EJ, Tranah GJ, Wirdefeldt K, Fang F, Harris TB, Chen H. Poor olfaction predicts long-term mortality among older adults in a community-based cohort. [Submitted]</p
Designed Multifunctional Spider Silk Enabled by Genetically Encoded Click Chemistry
No full textSpider silk is recognized for its exceptional mechanical properties and biocompatibility, making it a versatile platform for developing functional materials. In this study, a modular functionalization strategy for recombinant spider silk is presented using SpyTag/SpyCatcher chemistry, a prototype of genetically encoded click chemistry. The approach involves AlphaFold2-aided design of SpyTagged spider silk coupled with bacterial expression and biomimetic spinning, enabling the decoration of silk with various SpyCatcher-fusion motifs, such as fluorescent proteins, enzymes, and cell-binding ligands. The silk threads can be coated with a silica layer using silicatein, an enzyme for silicification, resulting in a hybrid inorganic–organic 1D material. The threads installed with RGD or laminin cell-binding ligands lead to enhanced endothelial cell attachment and proliferation. These findings demonstrate a straightforward yet powerful approach to 1D protein materials.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.ImPhys/Maresca grou
Surfing Scanning Probe Nanolithography at Meters Per Second
No full textScanning probe lithography (SPL)
as a maskless approach with a
low tool price can pattern a variety of materials at a nanometer or
even atomic resolution. However, the throughput of conventional SPLs
is extremely low due to their limited scanning speeds. Here, we report
a high-speed, probe-based method to continuously pattern the substrate
surface at a linear velocity of meters per second. We demonstrated
direct writings of nanoscale patterns by using ultrafast electron-induced
deposition inside a nanoscale flow at a patterning frequency of 20
MHz. The fast scan motion of the writing probe is precisely controlled
by using self-adaptive hydro- and aerodynamics functions of a patterning
head. The microscale electro-hydrodynamic ejection and microfluid
channels are used to deliver the precursor at high scanning speeds.
One patterning head can carry parallel probes to further enhance the
patterning throughput. This low-cost, maskless patterning method opens
new avenues to develop high-throughput nanomanufacturing techniques
Construction of Mo/Mo2C@C modified ZnIn2S4 Schottky junctions for efficient photo-thermal assisted hydrogen evolution
No full textPhotocatalytic water splitting on noble metal-free photocatalysts for H2 generation is a promising but challenging approach to realize solar-to-chemical energy conversion. In this study, Mo/Mo2C nanoparticles anchored carbon layer (Mo/Mo2C@C) was obtained by a one-step in-situ phase transition approach and developed for the first time as a photothermal cocatalyst to enhance the activity of ZnIn2S4 photocatalyst. Mo/Mo2C@C nanosheet exhibits strong absorption in the full spectrum region and excellent photo-thermal conversion ability, which generates heat to improve the reaction temperature and accelerate the reaction kinetics. Moreover, metallic Mo/Mo2C@C couples with ZnIn2S4 to form ZnIn2S4–Mo/Mo2C@C Schottky junction (denoted as ZMM), which prevents the electrons back transfer and restrains the charge recombination. In addition, conductive carbon with strong interfacial interaction serves as a fast charge transport bridge. Consequently, the optimized ZMM-0.2 junction exhibits an H2 evolution rate of 1031.07 μmol g−1 h−1, which is 41 and 4.3 times higher than bare ZnIn2S4 and ZnIn2S4–Mo2C, respectively. By designing novel photothermal cocatalysts, our work will provide a new guidance for designing efficient photocatalysts
Rapid and sensitive detection of mud crab Scylla serrata reovirus by a reverse transcription loop-mediated isothermal amplification assay
No full textPrecision Characterization of Site-Specific <i>O</i>‑Acetylated Sialic Acids on <i>N</i>‑Glycoproteins
No full textO-Acetylation is a common modification
of sialic
acid, playing a significant role in glycoprotein stability, immune
response, and cell development. Due to the lack of efficient methods
for direct analysis of O-acetylated sialoglycopeptides
(O-AcSGPs), the majority of identified O-acetylated sialic acids (O-AcSia) until now had
no glycosite/glycoprotein information. Herein, we introduced a new
workflow for precise interpretation of O-AcSGPs with
probability estimation by recognizing the characteristic B and Y ions
of O-AcSias. With further optimization of mass spectrometry
parameters, the method allowed us to identify a total of 171 unique O-AcSGPs in mouse serum. Although the majority of these O-AcSGPs were at a relatively low abundance compared with
their non-O-acetylated states, they were mainly involved
in peptidase/endopeptidase inhibitor activities. The method paves
the way for large-scale structural and functional analyses of site-specific O-AcSias in various complex samples as well as further identification
of many other similar chemical modifications on glycoproteins
Incidence of influenza-like illness (ILI) by year of birth.
No full textNational burden of ILI in Sweden from 1932 to 1970, data in 1947–1949 were excluded due to low report rates.</p
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