5 research outputs found

    Gestational weight gain standards based on the women enrolled in the Fetal Growth Longitudinal Study of the INTERGROWTH-21st Project : a prospective longitudinal cohort study

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    This project was supported by a generous grant from the Bill & Melinda Gates Foundation to the University of Oxford, for which we are very grateful.OBJECTIVE To describe maternal gestational weight gain (GWG) patterns in healthy pregnancies with good maternal and perinatal outcomes of women enrolled in the Fetal Growth Longitudinal Study of the INTERGROWTH-21st Project. DESIGN Prospective, longitudinal, observational multi-country study.SETTING Eight geographically diverse urban regions in Brazil, China, India, Italy, Kenya, Oman, UK and USA, April 2009 to March 2014. PARTICIPANTS Healthy, well-nourished and educated women, enrolled in the Fetal Growth Longitudinal Study component of the INTERGROWTH-21st Project, who had a body mass index (BMI) of ≥18.50 to ≤24.99 kg/m2 in the first trimester of pregnancy.MAIN OUTCOME MEASURES Maternal weight was measured using standardised methodology and identical equipment every 5±1 weeks from the first antenatal visit (<14+0 weeks’ gestation) to delivery. After ensuring that data from the study sites could be pooled, a multi-level, mixed effect, linear regression analysis for repeated measures, adjusted for gestational age was applied to produce the GWG values. RESULTS The within-site variance (59.6%) was six times higher than the between-sites’ variance (9.6%). Total mean GWG at 40 weeks’ gestation was 13.7 (SD 4.5) kg for women with a normal first trimester BMI. Fitted 3rd, 10th, 25th, 50th, 75th, 90th, and 97th smoothed GWG centiles by exact week of gestation are provided with equations for the mean and standard deviation to calculate any desired centiles according to gestational age in exact weeks. CONCLUSIONS This is the largest standardised study of healthy, well-nourished women ever to monitor GWG prospectively in a multi-country setting. The centiles generated are very robust and should help guide recommendations on optimal GWG worldwide.Peer reviewe

    Consuming the jihad : an enquiry into the subculture of internet jihadism

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    Recent years have seen a great deal of interest in phenomena such as Al Qaida ‘terrorism’, Islamic ‘radicalism’ or, increasingly, ‘jihadism’ - on the Internet. However, as I argue in this thesis, much work in these areas has been problematic for a number of reasons. Much literature has been narrowly focused on the security issues which it pre-judges the content to raise, and has therefore taken some aspects too literally while ignoring others. Conversely, where authors have addressed ‘jihadi’ content or ‘electronic jihad’ as a phenomenon unto itself, they have had difficulty making sense of it within religious studies or political communication frameworks. In this dissertation, I propose an alternative approach. Deliberately eschewing frameworks based on pre-existing conceptions of religion or politics, I draw, instead, on the academic literature on fandom and subcultural media consumption. Using this conceptual lens, I attempt to analyse jihadism on the Internet (which I define in terms of online consumption of, and identification with self-described ‘jihadi’ content) as a subcultural phenomenon on its own terms. I argue that, without necessarily denying the role that beliefs and ideals expressed in ‘jihadi’ content may sometimes have in sustaining the physical violence of the ‘global jihad’, the cultural practices which constitute Internet jihadism have a tactical logic of their own which may not always coincide with the ‘strategic’ interests of ‘global jihad’. By better understanding what ‘ordinary' jihadis, most of whom will never participate in violence, get out of their practices, and how they negotiate the apparent contradictions of their situation, I suggest that we may be better placed to understand not only why some jihadis ‘fail’ to negotiate these contradictions, but also, perhaps, to raise questions about how popular media consumption works more generally

    Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity

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    The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the presence of variants in each gene. An ensemble of LASSO logistic regression models was used to identify the most informative Boolean features with respect to the genetic bases of severity. The Boolean features selected by these logistic models were combined into an Integrated PolyGenic Score that offers a synthetic and interpretable index for describing the contribution of host genetics in COVID-19 severity, as demonstrated through testing in several independent cohorts. Selected features belong to ultra-rare, rare, low-frequency, and common variants, including those in linkage disequilibrium with known GWAS loci. Noteworthily, around one quarter of the selected genes are sex-specific. Pathway analysis of the selected genes associated with COVID-19 severity reflected the multi-organ nature of the disease. The proposed model might provide useful information for developing diagnostics and therapeutics, while also being able to guide bedside disease management. © 2021, The Author(s)

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Mrs. Ili-mliirk-* .-(Torts hi* tititnlttnl „ ' and k: per ram nl i ..- *ln* fis'.i.t.-. .,-. Ill-era) petiHls4 n* o Ktsinisb AithtI.-h, m.iri* i.i up ihnn i - ,r j war erttrtn lie illixl In iH-irn'r Msr.->. j — — 31. WIS Ills l-anrlj wa* taken to flwi i Summer Cleis nf *luik tin Iftc Pisnulnrlf I ■T*'«"" "'id ti-s*-. in Fslrviess' i-s-iih-i.t* i Tbr iLimm-r sMnlbi *••- lb. naht iibh I- there, not far frmn the shaft sshlrh i tul^oi'lZriu .""'m' (**^thrii '-j*^ '" !f**! a*f**J th* »T*r*' l,f Mrt- Heodrlcks.-- j CSIion M,-. ILnha^IIeai,! sVrwNut*. VhV, -^i**" O'V Star. (a.-1 si..! sr. (nr ihr- ln-r.ffit .,' all tvllti b>. ,r> ' —-—___^ I ««r*'i*.1 -'" I.H-, „.-. ......tn.. - ... Ptanr.. i.* iin,.,,™, i ,.[,,,( ,,.. IH |**lterns nre sure to lie* follow**! S^7..m!ur'llV.*->h..r'r!»,1\., I- .rsa I IDOr, tL*!* "E0"0 n*,r* " *'"*"•»>* American Red - + War Fund THE RECORD MONDAY June 18 TUESDAYJune19.£3,756.177bta/ TUESDAY June 19 .£3,756.17 7bta/3,756.17 WEDNESDAY June 20 £1,253.33 rota/5,009.50THURSDAYJune215,009.50 THURSDAY June 21 Total FRIDAYJune22 FRIDAY June 22 Total SATURDAYJune23 SATURDAY June 23 Total MONDAYJune25Total MONDAY June 25 Total + DON'T DELAY OASSIFIED ADVERTISEMENTS Mrs. Harland to Give Lecture Course in Pale Alto lira Haalar A. Harlan, ot Harkaler.: who baa bppn a guoat ot Mrs. K. 0. ' OrMO... durlna ute w,..-k npMlts in' ^ \ZL ">°°l ",' , '^'Jtl*,'-..W"'*»*~''^ "o* W C. TtsM.ll sraaklr tocture courta of six tobaerln- -jJTy-^^ «-7-ti tlon lecturoa upoo tbe historical aco-'0*^* POR RKWT Wantad—Baby bagrr 1° goodj For HenI -June 1, mofJtrn t-rsjon farslsbad flat, slaapias porah. Adtlta onlj. 427 KlpIIaj rtrawL 5 :t-tJ-slk notalnc aod geographic study of war' Waotesl—rosltlon la small famllj conditions and problems, gtrlof also b-r Japaaaaa womao cttrreot *ar ereots and tbelr Inter- f*bon« 3tlJ. pretatinn | Further snnouncemaol will be | *-V*nt«d—To hoy or lease la Ptlo ado -next week, turee win t,.. open to both men tod womnn |by latter. P. O. Box 211. Pah) Alto. Mrs Harland has been a deep stu- 8-12-lw* dent of these probtems and their on- ■ denying caoaatnl for a number of years For Hent—Three rooms, an moo- pUla root, ay |»d well fornUhed. Phooa Paie «-U-It* , Alto SUM. 2-2-U Heat—Furnished S-room These weekly lee ■A,t0 * tao^axn 6 to 6 room house in .boose; ,.*«plng porch, ruaca. tor- i to both men tod \*°°* lDt**A**t Olre foil t**ortietrJara,d4ao;ai5.J21Unr.oinare.F.7t»WWeretnodelbtUteUteat11eipertenracoaou.AtrialwilljsinceyoaSolares.Pbone20.ForRantFlatof4rooiaesnditleepla,porcb;moderaixaTaattyle.iQce.Eaqvlre530Lalrarttt7t?a112t/ForRant.Lars;etSBDyfaralahedWantedTonnewomanwouldroomsuiublefor1or2;rttntng.liketoretanykindofworkbythewater.Rentreasonable.521Freer.hourexceptwashingandcooklncsonstreet.lltifdhMrs.JamesFloodGivesai5. J21 Unr.oin are. F*. 7t»W We retnodel btU te Uteat 11 eipertenra coaou. A trial will j since yoa Solares. Pbone 20. For Rant—Flat of 4 rooiae snd i tleepla**, porcb; mo-dera ixaTaa- ttyle. i*Qce. Eaqvlre 530 L'alrarttt7 t?a •1 12-t/ For Rant.—Lars;e tSBDy faralahed Wanted—Tonne woman would room suiuble for 1 or 2; rttntng .like to ret any kind of work by the'water. 'Rent reasonable. 52*1 Freer . hour except washing and cooklnc son street. 'll-t-if-dh Mrs. James Flood Gives 15,000 to Red Crossl^rromr '"^tvS*** Continued from page 11 ['.-tails of ihe method to he ■-'I in a.t'onipllah this reaull -tj announced ttter T!.t o ., i ** from Elloi Wads worth, rluitrninn of me Atunrlr^n "i**. snd tnaj1 help lo rtetf ihe Wantts.1 Hon mh leaning and gar ■I. nir.;- bj John K M.-wion I* O ; Hog 25] I-bIo Alio 2*20*l*aT" For Rent—Modern --room cottage, sleeping porch and gxrags. ■■:■: :;■ ■■■:■■ fnrnlshed.f2*>. fi44 Byroa w-lS-lw* Wanted i rhlldren t> I mountaltia For Rent—Nice single room and refined nurse for -1 ■> room sulle. also a 3-roOm snlta. 'hool age to go to nrst floor AH clean, pleaaant and li" .*sj Pb PA 1101 furnbhod 154 Hamilton Ph. 482W * 30-lt ■ t-15 lm Wanted '.Voman to do light up- Kor Ren' $1*. 4-room flat, for- bnatlnn in man? minds ' *talrs work aod he\p with baby: nuhed. water and Ksrbajo paid by 'good "-ages Phone "ttJ Ci:*-t.' owner 3:2 Hamilton arenae. l-iillowing iirs iln. names wblcb -- - - ■ - - — - «-l»-tf ll ■ ons-dua had todt*. of Pslo \lto Wanted Position as -eKular gar- eoi-le she base > ontrihutexl | deoet by Japanese man l*.0 lo 270 I nino aerrlre t"*r month v[ Mlraks Ij>* Alloa. « 13-2W sir* r s. ,i* KtsrsMl Mr- t T de FnrtWl Me* uiir,i JsU-.sf.i, \ T d* Forest I. - ' lar* (iOUllon J..im II Wtttltaans Mjr* P. UatermSD Ji*nnlr lles-nej t.i-.,rgr HcLacblaa i>r U w. Aa*Ua* tt I* lll*tlt-p Iji Vetrr at Hon Ml** I'-l-sr* Page Mi*. *s h liradfor.1 11 \\ OOtJ Ml-*. M*rgnr>-t M.IjstliUo i jru* (a Ilaaldwin **4*ui|e* A. SmlUi Mr nml Mr* H 1 Perry Mlsa Helen Krep*. ■I U ItlstM- I-' K. tHsl-n J. KlBlt St>og (*tn~s» llir-1* (1.1 ri;: John "*U*»r*rli I'jiss-sni Jcuriin II. I.. Kloan Miir^iu.-i M I'l-aaajtW-s i.ertrtul.- I. (arr*Hr** 1 ol in M i,icgi>rj V A. KPTr—y I'rannt-J.i \ .1.— iitun li. K. Merrer J. s-.Lirr, Hi.iiil J. Kvans Mr. snd Mr* I. II Klngliam Mr*. J V Smith tl. I., lteaser Mr*.. I. I.. Iteanet I. I 1'iitlrr Mi*. i:.i. lift , oa, ti n. L- Co<1x Mrs- CA f.,-kt.-, M F Congdon Mr*. Amanda A Qj, O. F Fsi-rls P O Employees OSvid K.rkwccu r. J. Larifldon D. I. Grover lisrnice Grover C M Lynch J H. Phillips J W. Paulaen Mtaa E '■' Bproat Mrs E C T*,0itS Thoits flros i F Keeps Mrs. S M McKec '•i us Stalls McKee Mrs. F. M Wends*«a'd * C. Hob**-1 Brrrnce '. '■•-■-.■. -c - i LaufaM M Te—ot MISS E D Hmcs Mi-e. M A B Rlr;f Jchn A. ;>)■_ '•■ F C. Thiels w Oarale ' Sydney Sm.tl- U C. Seaoraaa M.SS F E Cor, Anna M Odyce SWII'.Ista*. |;„l..-s sii.i.m in LliU roil l, ("ompa.-o our sort, at JO [>er i ' las* Tou ;; >:■ for Arm's name ! lams qui- k i >sos. Phone 30 FOR bALS. For Rent Nir* furnished (-room house wlih foodern rons-enlencss t'lo*id m-tgliborhood :. *6 Warertey l-lt-21 For Kent During summer, cona- i'letety furnished up to-date 5-roooi Imngalo* steeping porch, garage with bedroom, garden. |60. water lorladed Hoi J Times ofBce •s-iri-if H>,rniinre ^» ihe piece reasonable Call 704| Kor Rent or Hal*- -4-room nous*, rti'ulars 4-14 lw* <3( Fbii*00 street Terms Phone P For Bale '':■.-*;.. a good toiod riding 1-otn centle safe for fatr ■J-refi Phon* M "H 4-12-tf L.43R before H a m or after • l.Latla C Tate. 130 Cowper street «-4-tf Snlr Studebaker 20 in flnr me* hanpal nni lire* Barf aln at lido in* »tre**t or Bos R Times S-U-«t For Rem -2 furnished buDplow and tarago. tie For Sale 100 laying hen*, year old. Owner going t*-ast. will tell ■ heap \*M>I' a.": Kor**, as-enue e-n-tf For *Uli* Ten Indian UCkfl hisas-y isylog strain. V Street »31 AddUon *it 6-19 2 Runner no. f ISlol) For Rent—Nit* tiont single bedroom 16 mo including !.-". .'.M Emerson street 5-31tf-db For Rent Furnished front room (npstalril. with or without bouse- ksseptng prlrlletes. 437 Kipling it s-:2-tf-ds MI.SCELLANKOUS F< >r Satp or and Pi B**ln , *or--< irr.tio-.;* objecton may cn- a s*i targa* ro., narno#1 t,j. mMn witti Arnerlcta • h-ap t! Itheo rQion aKains*t unitarian, Muasey Bldg . Washington i- \ \jt raio Alto liranrh hdq.. Sll Gllmaa st t 7-tf nilton avenue ■J-20-fil* !.»»' List he iai '. o* from the pr [ i Byre, Aihenon i.Um.-si reward .'oloreal Jersr* nilse-* of lUl-asrd jnenii* Alberto*- Mo Alto Aim ne* to l.oan pro*>erty P On O Improi-sd Box 142, S-Jl Palsy Palo tf I.I *. purae in Palo Quick serslre. Steam, srourtns; or French dry detains. Haia skapwd lo suit your ftca. Solares. Phone 2*. : Iberal Our prjraa ar* not .0 per cent I (Irs an* more Tou pay tor B.-id s nam* So- — lares reasonable cleaner Phon* 10 FARM LANDS Palntmj. tinting, paperhantlng Th* (uirrafmRi need) farmers as Now is tbg tlroe to ht*e jour boma sen as tight**-* T*o million three he* Hit fled. We Jo flrst-elass. tent ■ hundred tbousand strr* of Or*gon J.. ****** work use tha beat of mated. ICnlltoinufRsllroad Co (Irani l,*ru«* ••'*- "-d our prices ars most reeaon- ■ Tills, resetted in Polled States To ***•* ''hone as FUtlmstee free, li* opened for homestead* and sale [> K OrtBl Company. MS Hamll- Cimisining some of beu*t Und left In to" •*enu* Pbo*.* 2*tJ 3-24-tl* I'nlted Stale* 1-arge copyrbjhtM ' ~ ■ , man »howing land by sections and j desrrtptton of .oil. t-limaie rainfall. TESTING THE DENTIST. r lev a* lor- teni jieru t u ret, at' b> i-ounllr* Pom paid It Orant Land l^>t-aiing Co. Itoi 610 Portland. Ore »-21-3m .IH.VIHNI IU **-»•! t-Yen -1**-*. Fl-wni 1* ,11 3-* .«. led Sis. :ms iU. I... it. tt i .1 arm uf mer -* U. ,1 \ * u lib t ^le 210,. (-OUIl11.il i.r Wl Slam H er and ti tl ad other, at tnnoun e. hi iota for th« t»s*nl* four i..nn* of the <at n ts brotif.it uj. t ttnm, 31» _ Jl COONTRY HOME ill RUNNYiVIEDE 1 Iksii Itiej iiiake Is. 110 1 pa* | i Hit. ii- ... n^i . -um, ■■nigs 1 ■ , ALFRED J. ENGLE lttl l nlst-i-.it * Vst-niir Isr-isil Pat'-a Didn't Wtst ta Tsks Any Painfwi C*s**s**. To Illustrate orsentaJ bat*lts of thought Lord Crr>mer t*lls tn ib* Quar terly Review this story of tarn sll Vm*hm. khedlve of l.j*7;.f. It once happened that lamall was aulTerbig fivm ■■.*.■■-; tebc. lie sent for a Ear-.-pean dentist. Who tOld him thst he OITCht tO !:.vn tb* tooth .mi famail said Uat he was afnald It w.*siUl h* *ery ->atiirnL He was Inforiija-d lu repl* ihmi tf tie woald *U«w the di-nthu i« sittnlnlslrr Ian*fti InC gas to tilio be Woald feel nothing lie still dotil-ted hut tu-d lb* dentist to bring bis spparatus to the pwlacs*. TUe ilt-iii.-,: couipitrd and explained the pr.H-.-as I.. n,r klieJIvr Ismail then ium*ni.**eJ an stteudstii sod told blm to send ur list sentry wbo was at bis dour Wo*n i:.n o.jii srris*d tti* thedlT* ordrr**d btn to all down tn a rtislr and l>"iu**!.rd t**af .!.-,. ii.; Iu i.ke out a toa^h on either aide of bis iMw Ismal! ther, sskrd ihe man win-iLrr tie bad fell anytbtnti and ihr man |oM bitn ibsi in- bad n**t Bui la-usli w«s not rrr saOaaVd He aald that tb* sentry w»s a >..ut,» .irnvg a-isn and thai he would tike t.- •***.- ihr |.v,ir>rt-i-riit tried on s.-llir llir ..' "ri'.IT |a!:isli;ii.- Aes-***rdiBgli n* *i;.-i-.-n..;.t-j a sla*-w girl and had the tlrntlat estrtst two of her teelb. V uiitiig that sJke did us>t show r*,.;.■■-. ,. of ej,u-*ni* aUiTerlnji. u«* then 1.--..1-.. : :,-i ^ :.„, ujj, OWQ t^^-j oat
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