33 research outputs found

    e-Expense Claims System / Chong Chee Fui

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    This Project paper is prepared as to partially fulfill the requirement of the Bachelor of Computer Science. The development of e-Expense Claims System is highlighted in this document The e-Expense Claims System is to provide computerized and useful system for faculty administrators, lecturers and students in managing information more efficiently and effectively. It has to point out that the e-Expense Claims System will not be developed specific for small and medium size commercial companies. This is to ensure that the system can easily adapt to changes and can be customized for other organization with similar needs. The main purpose of the system is to computerize the manual system. This proposed electronic system enhances the expense claims application flows. The electronic Expense Claim application system to be located in company computer network center and accessible all authorized users connected to the company office. The expense claim is then submitted electronically. The system will calculate the total value of the expense claim and check each expense against the approval rules and set each expense's approval status appropriately. The decomposition of e-Expense Claims System into module and sub modules, function and features of each module are described in this docwnent as well. The system analysis, system design, system development and testing and maintenance are also focused

    Radial artery as an arterial graft in myocardial revascularisation surgery : laboratory and clinical assessments

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    Effects of hydrostatic distention on in vitro vasoreactivity of radial artery conduits

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    AbstractBackgroundSurgical preparation of coronary conduits may affect early and long-term patency through endothelial and smooth muscle injury. We investigated the effect of hydrostatic distention on the in vitro endothelial function and contractile properties of the human radial artery.MethodsHuman radial arteries were harvested and distended to physiologic pressure or suprasystemic pressure (>300 mm Hg) by using heparinized whole blood for 2 minutes. Distal segments were retrieved and prepared into 3-mm rings. These were mounted and stretched to optimum resting tension in oxygenated Krebs solution at 37°C. Contraction responses to potassium, norepinephrine, and serotonin and relaxation responses to acetylcholine and nitroprusside were evaluated. Undistended radial artery segments were used as controls.ResultsVasocontraction to all 3 contractile agonists was significantly different between groups. The radial artery subjected to suprasystemic pressure distention achieved the lowest percentage of maximum contraction (potassium, P < .001; norepinephrine, P < .05; serotonin, P < .05). The median effective concentration was also significantly reduced in this group, indicating increased sensitivity to all 3 agonists. Receptor-mediated contractility was significantly reduced in both distended groups when compared with controls. Relaxation to acetylcholine and nitroprusside was significantly reduced in the suprasystemic pressure–distended group, which had a tendency to vasospasm when exposed to a physiologic concentration of acetylcholine (10−6 mol/L). Median effective concentrations for both acetylcholine and nitroprusside were not different between groups.ConclusionsExcessive distention of the radial artery leads to a significant reduction in vasoreactivity, which may be attributed to a disruption of the vascular endothelium and media, with a propensity for graft spasm with exposure to acetylcholine

    Hyperglycemia and late onset seizures associated with quetiapine overdose

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    AbstractQuetiapine is an atypical antipsychotic agent which is being increasingly prescribed for psychotic disorders because it has fewer side effects than other antipsychotics. Consequently, overdoses of quetiapine have gained attention, given its widespread use. We report a 31-year-old man with schizophrenia who allegedly ingested 4 g of immediate-release quetiapine. He presented with common manifestations of quetiapine overdose such as sinus tachycardia, dry mouth and mucosa, hypotension, and coma. He also had hyperglycemia and late onset seizures (>24 hours post ingestion) which are not frequently reported. The patient was given activated charcoal while hypotension was managed with fluid resuscitation and intravenous noradrenaline. Intravenous diazepam and phenytoin were given for the seizure. The patient recovered without residual complications. Although a quetiapine overdose can result in serious medical complications, it can be managed by early intervention, mainly supportive care and close monitoring
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