791 research outputs found
Evaluating the effect of immune cells on the outcome of patients with mesothelioma
No full textMesothelioma is a rare cancer usually affecting the pleura. It is characteristically associated with inhalation of asbestos fibres and accounts for 1% of cancers in the United Kingdom. Median survival remains poor at 4-18 months despite treatment.Immunotherapy has established itself as an important treatment option in many solid tumours where survival benefit has been shown to be associated with CD8 infiltration. In mesothelioma, there are 3 small studies that suggest that CD8 infiltration may confer survival benefit.Here, a systematic assessment was undertaken of the prognostic and predictive value of infiltrating adaptive and innate immune cells in a large cohort of patients with advanced mesothelioma. A tissue microarray from 302 samples was constructed. Markers of adaptive immune response CD4+ T helper and CD8+ Cytotoxic T cells, FOXP3+Tregs, CD45RO+Memory T cells and B-cells (CD20+), and innate immune response; macrophages (CD68+), natural killer cells (CD56+) and neutrophils (NP57+) were evaluated.Surprisingly, CD8+ tumour infiltrating lymphocytes (TILs) did not predict for outcome. On multivariate analysis a high CD4+, high CD20+ and low NP57+ count were linked to better outcome in the epithelioid tumours. A low FOXP3+ predicted for good outcome in both epithelioid and non-epithelioid tumours.Next, multiplex immunohistochemistry was utilised to further evaluate CD4+ and CD8+ T cell subtypes. This established the presence of MHC class II expression on epithelioid mesothelioma tumour cells and confirmed that some CD4+ T cell subsets (Tissue resident memory cells and T follicular helper cells), were associated with better outcome in epithelioid mesothelioma. The intriguing question of why CD4 + T cells function as the outcome determining immune effectors in mesothelioma, remains to be determined.Mesothelioma-associated pleural fluid was evaluated to determine its utility as a surrogate for immune events in the solid tumour by transcriptomic analysis. T cells in the pleural fluid exhibited a phenotype characteristic of quiescent/naive cells
Location-Based Discovery and Network Handover Management for Heterogeneous IEEE 802.11ah IoT Applications
No full textThis research was funded by the Flemish IDEAL-IoT project (FWO SBO, grant nr. S004017N). The author Serena Santi is funded by the Flemish FWO SB grant (nr. 1S82120N). The author Filip Lemic was supported by the EU MSCA grant (nr. 893760). The computational resources were provided by the VSC (Flemish Supercomputer Center), funded by FWO and the Flemish Government -department EWI
Erratum: Lack of immunity against rubella among Italian young adults. [BMC Infect Dis., 17, (2017) (199)] Doi: 10.1186/s12879-017-2295-y
No full textAfter publication of this article [1], the authors noted that the given names and family names of all authors had been inverted, and are therefore incorrect in the original article. In the original article, the author names appear as the following: Gallone Maria Serena, Gallone Maria Filomena, Larocca Angela Maria Vittoria, Germinario Cinzia and Tafuri Silvio. However, this is incorrect, and the author names should appear as per the below: Maria Serena Gallone, Maria Filomena Gallone, Angela Maria Vittoria Larocca, Cinzia Germinario, Silvio Tafuri. The author names have been corrected in the author list and the citation for this Erratum
Justice, markets, and the family: an interview with Serena Olsaretti
No full textSerena Olsaretti (Naples, Italy, 1971) is a political philosopher at
Pompeu Fabra University (UPF), where she holds a research
professorship with the Catalan Institute of Research and Advanced
Studies (ICREA). Before moving to Barcelona, she was University Senior
Lecturer at the Faculty of Philosophy of Cambridge University. She
obtained a BA, MPhil, and DPhil degree in political philosophy from
Oxford University. Her DPhil thesis was supervised by G.A. Cohen.
Olsaretti’s research interests range widely, including the ethics of
markets, justice and the family, feminist philosophy, theories of
responsibility, and theories of well-being. She is the author of Liberty,
desert and the market (2004), and the editor of Desert and justice (2003),
Preferences and well-being (2006), and the Oxford handbook of
distributive justice (forthcoming). Her work has appeared in various
journals, including Analysis, Economics & Philosophy, Philosophy & Public
Affairs, and Proceedings of the Aristotelian Society. Olsaretti is one of the
editors of Law, Ethics, and Philosophy. She is the principal investigator
of Family justice: an analysis of the normative significance of procreation
and parenthood in a just society, a research project funded by a
European Research Council (ERC) consolidator grant.
The Erasmus Journal for Philosophy and Economics (EJPE)
interviewed Olsaretti about becoming a political philosopher, her work
on the ethics of markets and justice and the family, the ERC-project that
she directs, her views on teaching, and her advice for political
philosophy graduates aspiring to an academic career.This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 Research and Innovation programme (Grant Agreement Number: 648610)
Supp_minor_revision – Supplemental material for Association of central arterial stiffness with the presence and severity of diabetic retinopathy in Asians with type 2 diabetes
No full textSupplemental material, Supp_minor_revision for Association of central arterial stiffness with the presence and severity of diabetic retinopathy in Asians with type 2 diabetes by Xiao Zhang, Su Chi Lim, Subramaniam Tavintharan, Lee Ying Yeoh, Chee Fang Sum, Keven Ang, Darren Yeo, Serena Low and Neelam Kumari in Diabetes & Vascular Disease Research</p
Giurisprudenza romana nei papiri. Tracce per una ricerca
No full textThe volume presents a collection of essays devoted to circulation and transmission of Roman
legal knowledge in Late Antiquity, focusing on the description, edition and commentary of legal
fragments, on papyrus and parchment, from III to V c. AD; this period, between the classical age of
Roman legal jurisprudence and the great enterprise of the Digest of Justinian, is usually considered of
decadence in the traditional legal scholarship. The papyrus and parchment fragments, mostly found
in archaeological excavation in the Eastern Part of the Roman Empire or kept in Western Libraries
for centuries, contain texts different in topics and lengths: some are copies of works of classical
legal literature (e.g., Ulpian), some others are Greek or Latin-Greek legal commentaries; a few of
them bear text which are not known from other sources, therefore is not possible to guess if they are
original works or commentaries in somebody else work; there are excerpts from different authors
and works, interlinear and marginal glosses of considerable length. The same variety can be seen
in their book formats (from fine parchments books to re-used papyrus leaves, from pocket books to
wide margin pages, suitable to host long annotations) and scripts (from Latin legal uncial to cursive
scripts; a considerable bilingual and digraphical evidence is here discussed, too). All this diversity is
a significant witness of the lively word of Roman legal scholarship in Late Antiquity. Scholars from
different Italian and foreign universities (Bari, Naples, Parma, Pavia, Rome, Siena, Zurich) present
in this book the results of their investigations in the frame of the PRIN 2009 project ‘Legal literature
in Late Antiquity (III-V c. AD). History and Geography’. Ulrico Agnati (Parma) e Serena Ammirati
(Roma Tre-Pavia) present a re-edition and commentary of P.Oxy. XVII 2089, whose text is about
marital legacies. Author and title of the work are unknown. Sergio Alessandrì offer a new exegesis
of PSI XIV 1449, from book 32 of Ulpian, Ad edictum; Andrea Lovato discusses the contents of
P.Fay. 10 and P.Berol. inv. 11533, a papyrus fragment about imperial dispositions on the legacy of
the soldiers; and of Cod. Vind. 1b, which bears Ulpian Institutions; the essay of Federico Battaglia
(Zurich) focuses on the structure and the definitions of PSI XIII 1348; to Valerio Marotta (Pavia)
we owe a new commentary on P.Berol. inv. 6757, known as Fragmentum de iudiciis; Stefania
Pietrini (Siena)’s paper is about the meaning of the marginal glosses preserved through P.Ant. III
152, on dowry and the related legal actions; Jolanda Ruggiero (Roma, Sapienza) presents the wellknown
Fragments with the Sententiae of Paul, Leiden, BPL 2589. Fragments different in content
are nonetheless very important to reconstruct the legal thinking of Late Antiquity: Maria Chiara
Scappaticcio (Naples) edits and comments the legal glosses in P.Ryl. III 477, a papyrus collection
of Cicero’s speeches; Serena Ammirati offers a survey of bilingual Greek-Latin glossaries and their
graphic and textual interaction with legal fragments; Dario Mantovani (Pavia)’s reflections about the
origin of Digest offer a new insight on the continuity in the transmission of Roman classical legal
scholarship, which helps to frame all the fragments discussed in the book
Fig.-S1A.DPI_300 – Supplemental material for Association of central arterial stiffness with the presence and severity of diabetic retinopathy in Asians with type 2 diabetes
No full textSupplemental material, Fig.-S1A.DPI_300 for Association of central arterial stiffness with the presence and severity of diabetic retinopathy in Asians with type 2 diabetes by Xiao Zhang, Su Chi Lim, Subramaniam Tavintharan, Lee Ying Yeoh, Chee Fang Sum, Keven Ang, Darren Yeo, Serena Low and Neelam Kumari in Diabetes & Vascular Disease Research</p
Justice, markets, and the family: an interview with Serena Olsaretti
No full textSerena Olsaretti (Naples, Italy, 1971) is a political philosopher at
Pompeu Fabra University (UPF), where she holds a research
professorship with the Catalan Institute of Research and Advanced
Studies (ICREA). Before moving to Barcelona, she was University Senior
Lecturer at the Faculty of Philosophy of Cambridge University. She
obtained a BA, MPhil, and DPhil degree in political philosophy from
Oxford University. Her DPhil thesis was supervised by G.A. Cohen.
Olsaretti’s research interests range widely, including the ethics of
markets, justice and the family, feminist philosophy, theories of
responsibility, and theories of well-being. She is the author of Liberty,
desert and the market (2004), and the editor of Desert and justice (2003),
Preferences and well-being (2006), and the Oxford handbook of
distributive justice (forthcoming). Her work has appeared in various
journals, including Analysis, Economics & Philosophy, Philosophy & Public
Affairs, and Proceedings of the Aristotelian Society. Olsaretti is one of the
editors of Law, Ethics, and Philosophy. She is the principal investigator
of Family justice: an analysis of the normative significance of procreation
and parenthood in a just society, a research project funded by a
European Research Council (ERC) consolidator grant.
The Erasmus Journal for Philosophy and Economics (EJPE)
interviewed Olsaretti about becoming a political philosopher, her work
on the ethics of markets and justice and the family, the ERC-project that
she directs, her views on teaching, and her advice for political
philosophy graduates aspiring to an academic career
Fig.-S1B.DPI_300 – Supplemental material for Association of central arterial stiffness with the presence and severity of diabetic retinopathy in Asians with type 2 diabetes
No full textSupplemental material, Fig.-S1B.DPI_300 for Association of central arterial stiffness with the presence and severity of diabetic retinopathy in Asians with type 2 diabetes by Xiao Zhang, Su Chi Lim, Subramaniam Tavintharan, Lee Ying Yeoh, Chee Fang Sum, Keven Ang, Darren Yeo, Serena Low and Neelam Kumari in Diabetes & Vascular Disease Research</p
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