86 research outputs found
Drug permeability in tissue engineered models and cytotoxicity evaluations
No full textThis dissertation is a compilation of studies at both the cellular and in vitro tissue levels. It explores the in vitro chemo- and photo-toxicity of compounds - fractionated melanin (Mel-HEV) and chlorpromazine (CPZ) - in two human cell lines – HDF and HEKn and compares the effects to mouse fibroblast cell line ‘Balb/c 3T3’, cell line recommended by the European Center of Validation of Alternative Methods (ECVAM). The cell lines Balb/c 3T3 and HEKn were found sensitive to the phototoxic potential of CPZ. However, HDF showed insensitivity to phototoxic evaluation. The test compound, Mel-HEV, was
found to be non-phototoxic. Following the cellular toxicity studies, the dissertation progresses into the understanding the permeation analysis of Naltrexone HCL (NTXHCL) across tissue engineered buccal and skin membranes. The effects of two surfactants
(Brij 58® and Tween 80®) and changes in solution pH on in vitro permeation of NTX were observed. It was observed that the flux of 10mg/ml NTX solution (pH 6.8)
increased from 1.9 ± 0.6 (×102) to 13.9 ± 2.2 (×102) μg/cm2/h (approximately 6 fold) in presence of 1% Brij 58®. Increasing pH of NTX-HCl solution was found to increase the drug flux from 1.9 ± 0.6 (×102) (pH 6.8) to 3.0 ± 0.6 (×102) (pH 7.4) and 8.0 ± 3.5 (×102)
(pH 8.2) μg/cm2/h respectively. In tissue engineered human skin studies, a novel full thickness Human Skin Equivalent (HSE) containing a polymer electrospun mesh in the dermal component was developed and tested for mechanical strength comparative to
currently available collagen based HSE, human and porcine skin. A comparison of its morphology and permeability characteristics with ex vivo human and porcine skin was also performed. The mean Young’s modulus of polymeric HSE (0.4 ± 0.3 MPa) was
found similar to that of excised human skin (0.5 ± 0.1 MPa), much higher than of collagen HSE (0.009 ± 0.009 MPa). The histological sections of polymeric HSE have
been shown to exhibit well-formed dermal and fully differentiated epidermal layers. Polymeric HSE exhibited barrier properties which are comparatively weaker than those of ex vivo human/pig tissues but comparable to the commercially available model (Epiderm FT®).Ph. D.Includes bibliographical referencesIncludes vitaby Vishwas Ra
As an Application Development Platform
No full textwhere he has worked for the last fourteen years. In his current role, he is responsible for assisting organizations in envisioning, designing, and implementing enterprise solutions that are based on the.NET technologies. Vishwas also serves as the Microsoft Regional Director for the Washington DC area. As a Microsoft endorsed expert, he is regularly consulted by clients for his insight and informed perspective on implementing.NET based solutions. A regular industry speaker and author, he has presented at a number industry conferences as well as communit
Le Data Usage Index (DUI): méthodologie bibliométrique et données factuelles
No full textDeux chercheurs travaillant en Scandinavie, Peter INGWERSEN et Vishwas CHAVAN, ont commis le 15 décembre 2011 un article dans BMC Bioinformatics, intitulé « Indicators for the Data Usage Index (DUI): an incentive for publishing primary biodiversity data through global information infrastructure ». Il s’agit d’appliquer des principes de calcul bibliométrique à des données factuelles issues de réservoirs spécialisés. Les logs d’un serveur de données taxonomiques servent de banc de mesure. Il s’..
Towards Next Generation (data inclusive) Publishing
No full text<p>This presentation was given at "DataCite Summer Meeting 2012" held in Copenhagen, Denmark on 14 June 2012.</p
False arrhythmia alarm suppression using ECG, ABP, and photoplethysmogram
No full textThesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2009.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Cataloged from student-submitted PDF version of thesis.Includes bibliographical references (p. 91-93).A signal quality assessment scheme for the photoplethysmogram waveform recorded by a pulse oximeter has been created. The signal quality algorithm uses statistical methods on time-series and spectral analysis to locate high-frequency segments of the photoplethysmogram waveform. A photoplethysmogram pulse onset detector has been implemented for heart rate estimation. Application of the signal quality metric and photoplethysmogram pulse onset detector are demonstrated in an algorithm which suppresses false electrocardiogram critical arrhythmia alarms issued by bedside monitors in hospital intensive care units.by Anagha Vishwas Deshmane.M.Eng
Internet vis-a-vis marine biology
No full text463-468Internet is an amalgum of networks which reaches to more than 100 million people across the globe.
The satellite-telecommunicationbased computer network web hosts information on every aspect of life.
Marine biology related information too is being hosted on Internet by leading research organizations
worldwide. Present paper reviews the marine biology related informationavailable on Internet and Internet
potentials for marine biologistsfrom developingand underdevelopednations is discussed
A Tiny Tot Presentation
No full textThis booklet of sixteen pages contains three stories: The Snake and the Crows, The Monkeys and the Demon, and The Monkey and the Log. In this version of the first story, the clever fox advises the crows to pick up a princess' gold necklace and drop it into the snake's hole. The demon in the second story forbids the monkeys to drink from his lake, but apparently he himself cannot leave the lake. So the clever monkey-king devises a long tube from bamboo reeds and drinks out of the lake at a distance. In the third story, the curious monkey who pulls the wedge out of the tree is crushed to death. In most versions, just one part of his anatomy is--painfully--caught in the veritable vice that closes when the wedge is removed. The illustrations are large, simple cartoons. The monkeys' faces seem quite human. I am including for author and illustrator names that appeared when I did a websearch for the book.Sadhna Kapur
The data paper: a mechanism to incentivize data publishing in biodiversity science
No full text Background Free and open access to primary biodiversity data is essential for informed decision-making to achieve conservation of biodiversity and sustainable development. However, primary biodiversity data are neither easily accessible nor discoverable. Among several impediments, one is a lack of incentives to data publishers for publishing of their data resources. One such mechanism currently lacking is recognition through conventional scholarly publication of enriched metadata, which should ensure rapid discovery of 'fit-for-use' biodiversity data resources. Discussion We review the state of the art of data discovery options and the mechanisms in place for incentivizing data publishers efforts towards easy, efficient and enhanced publishing, dissemination, sharing and re-use of biodiversity data. We propose the establishment of the 'biodiversity data paper' as one possible mechanism to offer scholarly recognition for efforts and investment by data publishers in authoring rich metadata and publishing them as citable academic papers. While detailing the benefits to data publishers, we describe the objectives, work flow and outcomes of the pilot project commissioned by the Global Biodiversity Information Facility in collaboration with scholarly publishers and pioneered by Pensoft Publishers through its journals Zookeys, PhytoKeys, MycoKeys, BioRisk, NeoBiota, Nature Conservation and the forthcoming Biodiversity Data Journal. We then debate further enhancements of the data paper beyond the pilot project and attempt to forecast the future uptake of data papers as an incentivization mechanism by the stakeholder communities. Conclusions We believe that in addition to recognition for those involved in the data publishing enterprise, data papers will also expedite publishing of fit-for-use biodiversity data resources. However, uptake and establishment of the data paper as a potential mechanism of scholarly recognition requires a high degree of commitment and investment by the cross-sectional stakeholder communities.</p
Indicators for the Data Usage Index (DUI): an incentive for publishing primary biodiversity data through global information infrastructure
No full textAbstract Background A professional recognition mechanism is required to encourage expedited publishing of an adequate volume of 'fit-for-use' biodiversity data. As a component of such a recognition mechanism, we propose the development of the Data Usage Index (DUI) to demonstrate to data publishers that their efforts of creating biodiversity datasets have impact by being accessed and used by a wide spectrum of user communities. Discussion We propose and give examples of a range of 14 absolute and normalized biodiversity dataset usage indicators for the development of a DUI based on search events and dataset download instances. The DUI is proposed to include relative as well as species profile weighted comparative indicators. Conclusions We believe that in addition to the recognition to the data publisher and all players involved in the data life cycle, a DUI will also provide much needed yet novel insight into how users use primary biodiversity data. A DUI consisting of a range of usage indicators obtained from the GBIF network and other relevant access points is within reach. The usage of biodiversity datasets leads to the development of a family of indicators in line with well known citation-based measurements of recognition.</p
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