300 research outputs found
INFLUENCE OF RETRENCHMENT STRATEGY ON PERFORMANCE OF SAMEER AFRICA IN NAIROBI CITY COUNTY, KENYA
No full text<p><strong>Abstract:</strong> The entry of new competition from imported tires and independent suppliers has had a significant impact on operating costs in Sameer Africa. This impact has manifested itself in the form of lower sales volumes leading to lower profits. This study examined the influence of retrenchment strategy on performance of Sameer Africa in Nairobi City County, Kenya. The study applied a descriptive research design. The unit of analysis was Samer Africa in Nairobi City County, Kenya, and the unit of observation was 630 employees drawn from the following departments; Sales and Marketing, Operations, Human Resources, Information and Technology, Imports and Clearing, Audit and Risk Management. Proportional stratified sampling was used in the study to select samples from various subsets of the target population in order to ensure adequate representation of all cases. Simple random sample selection was used to select the sample size of 245 respondents. With the help of a semi-structured questionnaire, primary data was gathered. The questionnaire was piloted on 25 respondents from the same organization who weren't part of the main study in order to test its validity and reliability. The means and standard deviations of descriptive statistics were used to analyze quantitative data. The data were presented using tables and graphics. Correlation analysis and multiple analysis were used in inferential statistics to ascertain the relationship between the independent and dependent variables. The study discovered that the performance of Sameer Africa in Nairobi City County, Kenya, is positively and significantly impacted by reemployment strategy. The study concluded that retrenchment is a cost-management strategy that removes goods and services from the market and lessens competition. The study recommended that the management of the company can for divestment strategy is the case of severity of competition and the inability of the organization to cope with it.</p>
<p><strong>Keywords:</strong> Retrenchment Strategy, Organizational Performance.</p>
<p><strong>Title:</strong> INFLUENCE OF RETRENCHMENT STRATEGY ON PERFORMANCE OF SAMEER AFRICA IN NAIROBI CITY COUNTY, KENYA</p>
<p><strong>Author:</strong> Doris Mueni Mengo, Dr Eliud Obere</p>
<p><strong>International Journal of Management and Commerce Innovations </strong></p>
<p><strong>ISSN 2348-7585 (Online)</strong></p>
<p><strong>Vol. 11, Issue 2, October 2023 - March 2024</strong></p>
<p><strong>Page No: 8-13</strong></p>
<p><strong>Research Publish Journals</strong></p>
<p><strong>Website: www.researchpublish.com</strong></p>
<p><strong>Published Date: 04-October-2023</strong></p>
<p><strong>DOI: <a href="https://doi.org/10.5281/zenodo.8406732">https://doi.org/10.5281/zenodo.8406732</a></strong></p>
<p><strong>Paper Download Link (Source)</strong></p>
<p><strong><a href="https://www.researchpublish.com/papers/influence-of-retrenchment-strategy-on-performance-of-sameer-africa-in-nairobi-city-county-kenya">https://www.researchpublish.com/papers/influence-of-retrenchment-strategy-on-performance-of-sameer-africa-in-nairobi-city-county-kenya</a></strong></p>International Journal of Management and Commerce Innovations, ISSN 2348-7585 (Online), Research Publish Journals, Website: www.researchpublish.co
A Bayesian model for dynamic functional connectivity estimation in the human brain with structural priors
Get PDFStudies of dynamic functional connectivity have demonstrated that anatomical linkage is related to persistent functional connectivity. Bayesian models can leverage this connection by regularizing estimates of functional connectivity according to the strength of the corresponding structural connectivity. We proposed and evaluated the ability of such a model to recover covariance matrices. The model performed well in a high dimensional, small sample simulated setting. In addition, it exhibited robustness to temporal transformations and an ability to recover simulated data generated according to both discrete and continuous temporal dynamics. Finally, it outperformed sliding window baselines and anatomically un-informed baselines on estimating instantaneous covariances according to out-of-sample log likelihood on two task datasets.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2021-08-01The student, Sameer Manchanda, accepted the attached license on 2019-07-19 at 10:46.The student, Sameer Manchanda, submitted this Thesis for approval on 2019-07-19 at 10:50.This Thesis was approved for publication on 2019-07-19 at 11:21.DSpace SAF Submission Ingestion Package generated from Vireo submission #14389 on 2019-11-26 at 13:06:25Made available in DSpace on 2019-11-26T20:49:36Z (GMT). No. of bitstreams: 2
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Previous issue date: 2019-07-19Embargo set by: Seth Robbins for item 112988
Lift date: 2021-11-26T20:49:41Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemU of I Only Restriction Lifted for Item 112988 on 2021-11-27T10:15:09Z
Comparative study of Retinal Sensitivity through Microperimetry post intravitreal Avastin vs intravitreal triamcinolone acetonide for diabetic macular edema in pseudophakic eyes
No full textKaradi 3
No full textMusic, poetry, storytelling, and lively color come together to make each of these book/cassette pairs attractive. Each tape starts with a song in which Karadi introduces himself as a teller of stories. Here Kapi, the good king of the monkeys, has warned them not to let any mangoes float downriver towards Benares. Korung, a bad monkey, lets one float down, and soon enough the king has sent boats upriver to find this wonderful fruit. When the king and his hunters arrive, Kapi understands that he must form part of a bridge to freedom for his threatened people. He does this, and the king in admiration stops his men from firing arrows at Kapi. Korung, the last across, dashes Kapi down, but he revives. When the king assures Kapi that his people can return, he forgives Korung and welcomes him back. The book and audio cassette come together in a cellophane package. Though I will list each pair under both books and audio cassettes, I will keep them together in their packages under books.Script & Direction by Shobha Viswanat
Study of role of prognostic markers in the management of organophosphorus poisoning patients
Get PDFBackground: POP scale and serum cholinesterase levels may be effective indicators for mortality in organophosphorus poisoning. The objective of this study was to assess the POP scale score and serum cholinesterase levels at initial presentation in OP poisoning and its correlation with need for ventilator support and mortality.Methods: One hundred and fifty eligible participants were recruited, and POP scale and serum cholinesterase levels were assessed.Results: Total 32.7% patients died; of which 30 out of 75 belonged to moderate and 19 out of 22 patients belonged to severe group; as per POP scale score. 49 out of 75 in moderate poisoning and all patients in severe poisoning required ventilator support. With respect to serum cholinesterase level; 20 out of 23 and 29 out of 77 patients died in the severe and moderate poisoning categories respectively. Forty eight out of 77 in moderate poisoning and all patients in severe poisoning required ventilator support.Conclusions: Assessment by POP scale and serum cholinesterase levels is useful in assessing the need for ventilator support and are indicators of mortality in OP poisoning cases.</jats:p
Preference to co-author with other researchers based on socio-academic parameters.
No full textPreference to co-author with other researchers based on socio-academic parameters.</p
Understanding Parkinson’s disease: current trends and its multifaceted complications
Get PDFBackgroundParkinson’s disease (PD) is a multifactorial, progressive neurodegenerative disorder that primarily affects dopaminergic neurons in the substantia nigra. In addition to hallmark motor symptoms, it manifests a wide range of nonmotor complications, including cognitive decline, neuropsychiatric symptoms, autonomic dysfunction, and comorbid metabolic and infectious diseases.ObjectivesThis review aims to elucidate the molecular and cellular mechanisms underlying PD, explore the influence of genetic and environmental factors, evaluate current treatment limitations, and assess the clinical and socioeconomic burden globally. Emphasis is placed on emerging therapeutic avenues and innovative research directions.MethodsA structured literature review was conducted using PubMed, Scopus, and Web of Science databases. The search included articles published between 2010 and 2025, using keywords: “Parkinson’s disease,” “α-synuclein,” “dopaminergic degeneration,” “ferroptosis,” “deep brain stimulation,” “stem cell therapy,” and “AI in PD diagnosis.”ResultsThe review highlights a multifactorial etiology involving α-synuclein pathology, oxidative stress, mitochondrial dysfunction, genetic mutations (SNCA, LRRK2, VPS35), environmental toxins, and gut dysbiosis. Comorbidities such as HIV, diabetes, and cardiovascular disorders exacerbate disease burden. While Levodopa remains the gold standard, its limitations necessitate combination therapy and adjunct modalities such as deep brain stimulation and nanocarrier-based drug delivery. Emerging approaches—stem cell therapy, CRISPR-Cas9, and AI-enhanced diagnostics—show promise.ConclusionPD management requires a paradigm shift toward precision medicine. Advancing research into biomarkers, immunotherapy, and systems biology, coupled with equitable access to care and early diagnosis tools, is critical to mitigating the global impact of PD
Microchemical systems for kinetic studies of catalytic processes
Get PDFThesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 2002.Includes bibliographical references.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Silicon microfabrication techniques and scale-up by replication have for decades fueled spectacular advances in the electronics industry. More recently, with the rise of microfluidics, microfabrication has enabled the development of microchemical systems for a variety of chemical and biological applications. This work focuses on the development of these systems for improved gas phase heterogeneous catalysis research. The catalyst development process often requires fundamental information such as reaction rate constants, activation energies, and reaction mechanisms to gauge and understand catalyst performance. To this end, we have examined the ability of microreactors with a variety of geometries to efficiently obtain accurate kinetic information. This work primarily focuses on microfabricated packed-bed reactors that utilize standard catalyst particles and briefly explores the use of membrane based reactors to obtain kinetic information. Initial studies with microfabricated packed-beds led to the development of a microfabricated silicon reactor that incorporates a novel cross-flow design with a short pass multiple flow-channel geometry to reduce the gradients that often confound kinetics in macroscale reactors. The cross-flow geometry minimizes pressure drop though the particle bed and incorporates a passive flow distribution system composed of an array of shallow flow channels. Combined experiments and modeling confirm the even distribution of flow across the wide catalyst bed with a pressure drop [approx.] 1600 times smaller than typical microfabricated packed-bed configurations.(cont.) Coupled with the inherent heat and mass transfer advantages at the sub-millimeter length scale achievable through microfabrication, the cross-flow microreactor has been shown to operate in near-gradientless conditions and is an advantageous design for catalyst testing. The ability of microfabricated packed-beds to obtain accurate catalytic information has been demonstrated through experiments with phosgene generation over activated carbon, and CO oxidation and acetylene hydrogenation over a variety of noble metals on alumina. The advantages of using microreactors for catalyst testing is quantitatively highlighted throughout this work.by Sameer K. Ajmera.Ph.D
TRC210258, a novel TGR5 agonist, reduces glycemic and dyslipidemic cardiovascular risk in animal models of diabesity
No full textShitalkumar P Zambad, Davinder Tuli, Anoop Mathur, Sameer A Ghalsasi, Anita R Chaudhary, Shailesh Deshpande, Ramesh C Gupta, Vijay Chauthaiwale, Chaitanya DuttTorrent Research Centre, Torrent Pharmaceuticals Ltd, Gujarat, IndiaBackground: Patients with diabesity have a significantly increased risk of developing cardiovascular disease. Therefore, therapy addressing the multiple metabolic abnormalities linked with diabesity and leading to further reduction of cardiovascular risk is highly desirable. Activation of the TGR5 receptor holds therapeutic potential for diabesity. In the present study, we evaluated the efficacy of TRC210258, a novel TGR5 agonist, in clinically relevant animal models of diabesity.Methods: A novel small molecule, TRC210258 (N-(4-chlorophenyl)-2-(4-fluoro phenoxy)-N-methylimidazo (1, 2-a) pyrimidine-3-carboxamide), was synthesized. The in vitro TGR5 receptor activation potential of TRC210258 was assessed by cyclic adinosine monophosphate (cAMP) assay and cAMP-responsive element reporter assay using cells overexpressing the human TGR5 receptor. The effect of TRC210258 on glucagon-like peptide-1 release was evaluated in vitro using a human enteroendocrine cell line. The effect of TRC210258 on energy expenditure and glycemic control was evaluated in high-fat diet-induced obese mice. Additionally, the effect of TRC210258 on dyslipidemic parameters was determined in high fat-fed hamsters.Results: TRC210258 demonstrated potent TGR5 agonist activity, with enhanced glucagon-like peptide-1 release and energy expenditure. Treatment with TRC210258 resulted in better glycemic control and improved parameters of dyslipidemia such as plasma triglyceride, low-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol levels. Treatment with TRC210258 also improved emerging dyslipidemic cardiovascular risk parameters, including remnant cholesterol and triglyceride clearance.Conclusion: This study highlights the potential of TRC210258, a novel TGR5 agonist, to improve dyslipidemic cardiovascular risk beyond glycemic control in patients with type 2 diabetes.Keywords: TGR5, diabesity, atherogenic dyslipidemia, triglyceride clearance, remnant cholesterol, cardiovascular risk
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