3,505 research outputs found
The development of a set of key points to aid clinicians and researchers in designing and conducting n-of-1 trials
No full textIntroduction
n-of-1 trials are undertaken to optimise the evaluation of health technologies in individual patients. They involve a single patient receiving treatments, both interventional and control, consecutively over set periods of time, the order of which is decided at random. Although n-of-1 trials are undertaken in medical research it could be argued they have the utility to be undertaken more frequently. We undertook the National Institute for Health Research (NIHR) commissioned DIAMOND (Development of generalisable methodology for n-of-1 trials delivery for very low volume treatments) project to develop key points to assist clinicians and researchers in designing and conducting n-of-1 trials.
Methods
The key points were developed by undertaking a stakeholder workshop, followed by a discussion within the study team and then a stakeholder dissemination and feedback event. The stakeholder workshop sought to gain the perspectives of a variety of stakeholders (including clinicians, researchers and patient representatives) on the design and use of n-of-1 trials. A discussion between the study team was held to reflect on the workshop and draft the key points. Lastly, the stakeholders from the workshop were invited to a dissemination and feedback session where the proposed key points were presented and their feedback gained.
Results
A set of 22 key points were developed based on the insights from the workshop and subsequent discussions. They provide guidance on when an n-of-1 trial might be a viable or appropriate study design and discuss key decisions involved in the design of n-of-1 trials, including determining an appropriate number of treatment periods and cycles, the choice of comparator, recommended approaches to randomisation and blinding, the use of washout periods and approaches to analysis.
Conclusions
The key points developed in the project will support clinical researchers to understand key considerations when designing n-of-1 trials. It is hoped they will support the wider implementation of the study design
Happy Hour with Robin Sacks
No full textRobin Sacks is the author of Get Off My Bus!: How to Get Clarity, Get in the Driver\u27s Seat, and Get Moving in Your Life! Introduction by Kristen Kuhlman, LSW, LHNA, MBA/HCM DHA Candidate
Public management : Reinventing Government: a symposium. by Robin Butler
No full texttag=1 data=Public management : Reinventing Government: a symposium. by Robin Butler
tag=2 data=Butler, Robin
tag=3 data=Public Administration,
tag=4 data=72
tag=5 data=2
tag=6 data=Summer 1994
tag=7 data=263-270.
tag=8 data=MANAGEMENT%PUBLIC SERVICE
tag=10 data=The author indicates how the major themes of the book [Reinventing Government] can be seen to correspond with many of the recent management initiatives in UK government.
tag=11 data=1994/6/8
tag=12 data=94/0490
tag=13 data=CABThe author indicates how the major themes of the book [Reinventing Government] can be seen to correspond with many of the recent management initiatives in UK government
Robin Becker, 16th Annual ODU Literary Festival
No full textRobin Becker is the author of Giacometti’s Dog, published in 1990 by the University of Pittsburgh Press. Her previous books are Backtalk and Personal Effects, both published by Alice James Books She has received fellowships in poetry from the Massachusetts Artists Foundation and the National Endowment for the Arts. Her poems appear in many journals including Agni, The American Poetry Review, The Kenyon Review, and Ploughshares. She has published book reviews in Belles Lettres, The Boston Globe, The Boston Review, Prairie Schooner and The Women’s Review of Books She teaches in the Program in Writing and Humanistic Studies at Massachusetts Institute of Technology. This year she is Visiting Poet at Pennsylvania State University. Robin Becker serves as Poetry Editor for The Women’s Review of Books and as a member of the board of directors of Associated Writing Programs
Author Robin Silbergleid reads from her memoir "Texas girl," and her soon to be published book of poetry, "The baby book" at the Michigan Writers Series
No full textAuthor Robin Silbergleid reads from her memoir "Texas girl," and her soon to be published book of poetry, "The Baby Book." Introductory remarks are provided by MSU Professor Telaina Eriksen and MSU Librarian Michael Rodriguez. Part of the MSU Libraries' Michigan Writers Series. Held at the MSU Main Library and sponsored by the MSU Department of English and the Center for Gender in Global Context
Writer Robin Lippincott reads from novel In the Meantime
No full textIncludes descriptive metadata provided by producer in MP3 file: "Listen to writer Robin Lippincott read from his new novel In the Meantime, which tracks the intertwined lives of three friends for six decades. Lippincott is also the author of Mr. Dalloway. The reading was part of the Gertrude Vanderbilt and Harold S. Vanderbilt Visiting Writers Program at Vanderbilt University. It was recorded on Oct. 31, 2007.
The Robin\u27s Petition
No full textA Robin asks for shelter during the winter.https://egrove.olemiss.edu/kgbsides_uk/2259/thumbnail.jp
- …
