1,358,588 research outputs found
Bioanalysis Young Investigator: Narahara Chari Dingari
No full text Supervisor’s supporting comments It gives me enormous pleasure to nominate Narahara Chari Dingari for the Bioanalysis Young Investigator 2011 award. Chari has been working with me since 2009 and we have worked together on numerous biomedical projects, including ones where he has put lots of effort into publishing new methods and findings in prestigious journals such as Analytical Chemistry, Journal of Biomedical Optics, Analytical and Bioanalytical Chemistry and Biomedical Optics Express. I have found him to be very diligent with high academic interests and intellectual ability. Chari is a promising scientist motivated to work in multidisciplinary research areas and is quite capable of setting up his own team and carrying out independent research. Chari’s current work bears direct impact in the diagnosis of important diseases such as breast cancer and malaria as well as in noninvasive blood glucose detection. He has excellent communication skills and is highly motivated in his pursuit of an advanced career in biomedical optics, spectroscopy and bioanalysis. I have extremely high expectations for him in the future as he continues to grow as an independent research scientist and a team leader. His eventual goal is to join the faculty of a major university and build a high-impact research laboratory. I strongly recommend him without any reservations for this prestigious award. </jats:p
Reply to Solow
No full textHere we reply to Robert Solow’s comment (forthcoming) on our work (Chari and Kehoe (2007)).Macroeconomics
Les briques cuites du Chari
No full textThe layers of burnt bricks of the Chari (Migri, Onoko, Mondo, Baigane, Mafaling and Bousso) seem to be the most southerly of West and Central Africa.
For the most part oblong, these bricks have one flat, and one curved, face. The puddling of the earth with an animal or vegetable fatty matter gives the bricks a particular texture and density.
The bricks were introduced by groups of the kouka-boulala which seized the cities of Chari probably around the 16th century.
The bricks served for the construction of certain habitations of chiefs, but principally to enclose their concessions.
They symbolized power in Chari, likewise in the rest of the Chadian bassin, and the submission of other cities on the banks of the Chari manifested itself in the periodic furnishing of a quota of bricks.
The conquest of the Chari by Massenya, under Mohammed El Amin called Mbang Hadji, in the middle of the 18th century, brought about the prohibition of firing bricks there.Les gisements de briques cuites du Chari (Migri, Onoko, Mondo, Baigane, Mafaling et Bousso) semblent être les plus méridionaux de l’Ouest et du Centre africains.
En majorité oblongues, ces briques présentent une face plate, l’autre bombée. Le corroyage de la terre avec une matière grasse d’origine animale ou végétale leur confère une texture et une densité particulières.
Elles furent introduites par des éléments kouka-boulala qui coiffèrent les cités du Chari vraisemblablement autour du XVIème siècle.
Ces briques servirent à construire certains éléments d’habitation des chefs, mais surtout à enclore leurs concessions.
Elles symbolisaient le pouvoir, comme du reste dans tout le bassin tchadien, et la soumission d’autres cités des rives du Chari se matérialisait par la fourniture périodique de leur quote-part de briques.
La conquête du Chari par Massenya sous Mohammed El Amin dit Mbang Hadji, au milieu du XVIIIème siècle, s’assortit de l’interdiction d’y cuire des briques.Seignobos Christian. Les briques cuites du Chari. In: 2000 ans d’histoire africaine. Le sol, la parole et l’écrit. Mélanges en hommage à Raymond Mauny. Tome I. Paris : Société française d'histoire d'outre-mer, 1981. pp. 265-279. (Bibliothèque d'histoire d'outre-mer. Études, 5-6-1
Les briques cuites du Chari
No full textThe layers of burnt bricks of the Chari (Migri, Onoko, Mondo, Baigane, Mafaling and Bousso) seem to be the most southerly of West and Central Africa.
For the most part oblong, these bricks have one flat, and one curved, face. The puddling of the earth with an animal or vegetable fatty matter gives the bricks a particular texture and density.
The bricks were introduced by groups of the kouka-boulala which seized the cities of Chari probably around the 16th century.
The bricks served for the construction of certain habitations of chiefs, but principally to enclose their concessions.
They symbolized power in Chari, likewise in the rest of the Chadian bassin, and the submission of other cities on the banks of the Chari manifested itself in the periodic furnishing of a quota of bricks.
The conquest of the Chari by Massenya, under Mohammed El Amin called Mbang Hadji, in the middle of the 18th century, brought about the prohibition of firing bricks there.Les gisements de briques cuites du Chari (Migri, Onoko, Mondo, Baigane, Mafaling et Bousso) semblent être les plus méridionaux de l’Ouest et du Centre africains.
En majorité oblongues, ces briques présentent une face plate, l’autre bombée. Le corroyage de la terre avec une matière grasse d’origine animale ou végétale leur confère une texture et une densité particulières.
Elles furent introduites par des éléments kouka-boulala qui coiffèrent les cités du Chari vraisemblablement autour du XVIème siècle.
Ces briques servirent à construire certains éléments d’habitation des chefs, mais surtout à enclore leurs concessions.
Elles symbolisaient le pouvoir, comme du reste dans tout le bassin tchadien, et la soumission d’autres cités des rives du Chari se matérialisait par la fourniture périodique de leur quote-part de briques.
La conquête du Chari par Massenya sous Mohammed El Amin dit Mbang Hadji, au milieu du XVIIIème siècle, s’assortit de l’interdiction d’y cuire des briques.Seignobos Christian. Les briques cuites du Chari. In: 2000 ans d’histoire africaine. Le sol, la parole et l’écrit. Mélanges en hommage à Raymond Mauny. Tome I. Paris : Société française d'histoire d'outre-mer, 1981. pp. 265-279. (Bibliothèque d'histoire d'outre-mer. Études, 5-6-1
The Ribosome Cooperates with the Assembly Chaperone pICln to Initiate Formation of snRNPs
No full textSummaryThe formation of macromolecular complexes within the crowded environment of cells often requires aid from assembly chaperones. PRMT5 and SMN complexes mediate this task for the assembly of the common core of pre-mRNA processing small nuclear ribonucleoprotein particles (snRNPs). Core formation is initiated by the PRMT5-complex subunit pICln, which pre-arranges the core proteins into spatial positions occupied in the assembled snRNP. The SMN complex then accepts these pICln-bound proteins and unites them with small nuclear RNA (snRNA). Here, we have analyzed how newly synthesized snRNP proteins are channeled into the assembly pathway to evade mis-assembly. We show that they initially remain bound to the ribosome near the polypeptide exit tunnel and dissociate upon association with pICln. Coincident with its release activity, pICln ensures the formation of cognate heterooligomers and their chaperoned guidance into the assembly pathway. Our study identifies the ribosomal quality control hub as a site where chaperone-mediated assembly of macromolecular complexes can be initiated
Les progrès de la Riziculture dans L'Oubangui-Chari
No full textBaudon A. Les progrès de la Riziculture dans L'Oubangui-Chari. In: Revue de botanique appliquée et d'agriculture coloniale, 2ᵉ année, bulletin n°13, septembre 1922. pp. 478-482
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Macdonald Polynomials and Graded Characters of Generalized Demazure Modules of so(2n)[t]
No full textIn recent work published by Biswal, Chari, Shereen, and Wand the authors defined a family of symmetric polynomials indexed by pairs of dominant integral weights, G_{\nu, \lambda}(z,q) where z=(z_1, \cdots. z_{n+1})\in\C^{n+1}, and determined that G_{0, \lambda}(z,q) is the graded character of a level two Demazure module for sl_{n+1}[t]. The aim of this thesis is to construct analogues of these polynomials for the generalized Demazure modules for so_{2n}[t] as they are presented by Chari, Davis, and Moruzzi. We do this by constructing modules which interpolate from the presentation provided in that paper and local Weyl modules. We then create short exact sequences between them to relate their graded characters. This allows us to identify coefficients in the corresponding graded characters with the coefficients in G_{\nu,\lambda}(z,q)
Sample preparation of biological macromolecular assemblies for the determination of high-resolution structures by cryo-electron microscopy.
No full textSingle particle cryo-EM has recently developed into a powerful tool to determine the 3D structure of macromolecular complexes at near-atomic resolution, which allows structural biologists to build atomic models of proteins. All technical aspects of cryo-EM technology have been considerably improved over the last two decades, including electron microscopic hardware, image processing software and the ever growing speed of computers. This leads to a more widespread use of the technique, and it can be anticipated that further automation of electron microscopes and image processing tools will soon fully shift the focus away from the technological aspects, onto biological questions that can be answered. In single particle cryo-EM, no crystals of a macromolecule are required. In contrast to X-ray crystallography, this significantly facilitates structure determination by cryo-EM. Nevertheless, a relatively high level of biochemical control is still essential to obtain high-resolution structures by cryo-EM, and it can be anticipated that the success of the cryo-EM technology goes hand in hand with further developments of sample purification and preparation techniques. This will allow routine high-resolution structure determination of the many macromolecular complexes of the cell that until now represent evasive targets for X-ray crystallographers. Here we discuss the various biochemical tools that are currently available and the existing sample purification and preparation techniques for cryo-EM grid preparation that are needed to obtain high-resolution images for structure determination
Prospects and Limitations of High-Resolution Single-Particle Cryo-Electron Microscopy
No full textSingle particle cryo-electron microscopy (cryo-EM) has matured into a robust method for the determination of biological macromolecule structures in the past decade, complementing X-ray crystallography and nuclear magnetic resonance. Constant methodological improvements in both cryo-EM hardware and image processing software continue to contribute to an exponential growth in the number of structures solved annually. In this review, we provide a historical view of the many steps that were required to make cryo-EM a successful method for the determination of high-resolution protein complex structures. We further discuss aspects of cryo-EM methodology that are the greatest pitfalls challenging successful structure determination to date. Lastly, we highlight and propose potential future developments that would improve the method even further in the near future
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