3,391 research outputs found
The fliU and fliV genes of Salmonella muenchen are expressed as a single ORF in Salmonella choleraesuis.
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Porcine congenital splayleg is characterised by muscle fibre atrophy associated with relative rise in MAFbx and fall in P311 expression
Full text link<p>Background: Porcine congenital splayleg (PCS) is the most important congenital condition of piglets, associated with lameness and immobility, of unknown aetiology and pathogenesis, hence the need to better understand the condition by defining, in the first instance, its histopathology and molecular pathology.</p>
<p>Results: Semitendinosus, longissimus dorsi, and gastrocnemius muscles were removed from 4 sets of 2-day-old splayleg piglets, each with a corresponding normal litter mate. Based on immunohistochemistry and histological image analysis, PCS piglets showed significantly smaller fibre size without any accompanying sign of inflammation. Although there was no dramatic change in fibre type composition in affected muscles, several structural myosin heavy chain genes were significantly down-regulated. MAFbx, a major atrophy marker, was highly up-regulated in nearly all PCS muscles, in comparison with controls from normal litter mates. In contrast, P311, a novel 8 kDa protein, was relatively down-regulated in all the PCS muscles. To investigate a functional role of P311 in skeletal muscle, its full-length cDNA was over-expressed in murine C2C12 muscle cells, which resulted in enhanced cell proliferation with reduced myotube formation. Hence, reduced P311 expression in PCS piglets might contribute to atrophy through reduced muscle cell proliferation. P311, predictably, was down-regulated by the over-expression of calcineurin, a key signalling factor of muscle differentiation.</p>
<p>Conclusion: We demonstrated that PCS is a condition characterised by extensive fibre atrophy and raised fibre density, and propose that the combined differential expression of MAFbx and P311 is of potential in the diagnosis of subclinical PCS.</p>
Tamper Detection and Restoring System for Medical Images Using Wavelet-based Reversible Data Embedding
No full textTransmission and clinical features of enterovirus 71 infections in household contacts in Taiwan
No full textFree boundary problems and the set-valued mappings
No full texthttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1983RD96000001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701MathematicsSCI(E)39ARTICLE11-284
Aminoguanidine prevents fructose-induced arterial stiffening in Wistar rats: aortic impedance analysis
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Study on the differentiation of the DNA fingerprint between the human-origin (RH) and pig-origin (GC/YC) strains of Toxyplasma gondii.
No full textOn the Nash point equilibria in the calculus of variations
No full textAbstractThe existence and partial regularity of the Nash point equilibria for a pair of multiple integrals J(u, v) = ∝Ω F(x, u, v, ▽u, ▽v) dx, K(u, v) = ∝Ω G(x, u, v, ▽u, ▽v) dx, are studied.The conditions as well as the results are similar to those for local minima obtained by Acerbi, Fusco and Giaquinta, Giusti
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