1,997 research outputs found
A practical preparation of key intermediates for myo-inositol phosphates.
No full textA simple and practical synthetic procedure for the versatile intermediates, (±)-1,2:5,6-di-O-isopropylidene-myo-inositol and (±)-6-O-benzoyl-1,2:4,5-di-O-isopropylidene-myo-inositol, is described.11sci
Inositol phospholipid pathway inhibitors and regulators
No full textIn health and disease. physiological homeostasis depends on the ability: of cells to respond to the environment and other cells. Communications between cells are mediated by a variety of chemical signals such as hormones, growth factors, neurotransmitters or electric signals [1]. Although chemical signalling occurs by a. number of different mechanisms, signalling molecules can be classified into two general types according to their ability to permeate the plasma membrane. While hydrophobic hormones easily penetrate the lipid bilayer and directly act on intracellular or nuclear receptors, cell impermeant, hpdrophilic molecules bind to cell surface receptors embedded ill the lipid bilayer and thus generate second messengers that transmit the extracellular signal to the intracellular compartment. In many different cell types, this latter process, referred to as trans-membrane signalling or signal transduction, is mediated by protein phosphorylation cascades, ion fluxes, as well as changes in the levels of phospholipid breakdown products including diacylglycerol and myo-inositol containing second messengers [2]. Misregulation of inositol signalling pathways has been implicated in a variety of diseases, including hypertension, diabetes and neuronal disorders, prompting the development of pharmacological agents that re-establish normal inositol signalling. Here, we review the patent literature surrounding small molecule inositol derivatives and discuss the challenges that remain before therapeutic applications become practical.1114sciescopu
SYNTHESIS OF ALL POSSIBLE REGIOISOMERS OF MYOINOSITOL TETRAKISPHOSPHATES
No full textopen1131sciescopu
Syntheses of myo-inositol-1,2,3,5- and -2,4,5,6-tetrakisphosphates, unusual inhibitors of myo-inositol-1,4,5-trisphosphate 3-kinase
No full textX1111sciescopu
Inhibition and reversal of myogenic differentiation by purine-based microtubule assembly inhibitors
No full textUsing a muscle cell differentiation screen, we have identified myoseverin from a 2,6,9-trisubsituted purine library as a purine-based microtubule binding molecule [1]. Structure-activity relation studies of myoseverin identify positions N2 and N6 to be critical for inhibiting muscle differentiation. Inhibition of microtubule polymerization induced the reversion of terminally differentiated myotubes to mononucleated cells that were responsive to both growth and differentiation conditions, without any observable cytotoxicity. Comparison of myoseverin derivatives to taxol, vinblastine, nocodazole, and colchicine identify myoseverin's effect as being selectively reversible in addition to lacking the cytotoxic effects of these non-purine-based microtubule-disrupting molecules. Myoseverin, as a purine-based microtubule inhibitor, reverted terminal muscle-differentiated cells to a state that was responsive to environmental cues. These results suggest that myoseverin may have applications in muscle regeneration and stem cell differentiation.1161sciescopu
Molecular interactions of synthetic inositol phosphates with inositol 1,4,5-trisphosphate 3-kinase
No full text11sciescopu
Development of novel cell-permeable DNA sensitive dyes using combinatorial synthesis and cell-based screening
No full textA novel cell-permeable DNA fluorescence sensor was developed based on combinatorially-created styryl dyes and cell-based localization screening.1167sciescopu
- …
