45,790 research outputs found
Materials for Chang et al. (2011), Chang & Yao (2016, 2019, 2024)
No full textTest materials for Chang and Yao (2024, "An individual-differences perspective on variation in heritage Mandarin speakers", The Phonetics and Phonology of Heritage Languages), as well as Chang and Yao (2019, "Production of neutral tone in Mandarin by heritage, native, and second language speakers", Proceedings of ICPhS 2019), Chang and Yao (2016, "Toward an understanding of heritage prosody: Acoustic and perceptual properties of tone produced by heritage, native, and second language speakers of Mandarin", Heritage Language Journal), and Chang, Yao, Haynes, and Rhodes (2011, "Production of phonetic and phonological contrast by heritage speakers of Mandarin", JASA), which are shareable publicly according to the study's IRB protocol: namely, the Language Background Questionnaire (provided in PDF format). The list of critical linguistic stimuli in Chang and Yao (2019) is provided in pinyin in the paper, and in simplified Chinese characters in Chang and Yao (2016). The other stimuli produced in the same experimental session are listed in Chang and Yao (2016), as well as in Chang, Yao, Haynes, and Rhodes (2011)
Datasets for Chang et al. (2011), Chang & Yao (2024)
No full textFull datasets for Chang and Yao (2024, "An individual-differences perspective on variation in heritage Mandarin speakers", The Phonetics and Phonology of Heritage Languages) as well as Chang, Yao, Haynes, and Rhodes (2011, "Production of phonetic and phonological contrast by heritage speakers of Mandarin", JASA): a phonetic dataset and a socio-demographic dataset. Both datasets are provided in text format (.txt). Detailed explanations of each variable in the socio-demographic dataset are provided in the R Markdown file on the "Visualizations and Code" page (https://osf.io/5hyjf/)
Datasets for Chang & Yao (2016, 2019)
No full textFull datasets for Chang and Yao (2019, "Production of neutral tone in Mandarin by heritage, native, and second language speakers", Proceedings of ICPhS 2019) as well as Chang and Yao (2016, "Toward an understanding of heritage prosody: Acoustic and perceptual properties of tone produced by heritage, native, and second language speakers of Mandarin", Heritage Language Journal), in Excel format (.xlsx) and tab-delimited text format (.txt). Sheet 1 of the Excel file provides the acoustic data; Sheet 2, the perceptual data related to tone quality, i.e. tone identification (tonal intelligibility) and perceived goodness; Sheet 3, the perceptual data related to socio-demographic classification of the talkers; Sheet 4, the demographic data for the talker participants; and Sheet 5, the demographic data for the listener (rater) participants. Sheet 6 provides a key explaining each column of the data spreadsheets in sheets 1-5
Visualizations and Code for Chang & Yao (2024)
No full textHigh-resolution, color versions of visualizations in Chang and Yao (2024, "An individual-differences perspective on variation in heritage Mandarin speakers", The Phonetics and Phonology of Heritage Languages), along with supplementary visualizations and the R code used to process the data and produce the visualizations
Materials for Yao et al. (2024, 2026)
No full textMaterials used in the speech production task and the social perception experiment reported in Yao, Li, Li, and Chang (2024, "Perceiving the social meanings of creaky voice in Mandarin Chinese", Speech Prosody 2024) and Yao, Li, and Chang (2026, "Social perception of creaky voice in Mandarin Chinese: Everyone's gender matters", Humanities and Social Sciences Communications), in Excel (.xlsx) and PDF format
Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease
Get PDFChronic obstructive pulmonary disease (COPD) is a global health problem. The current therapies for COPD are poorly effective and the mainstays of pharmacotherapy are bronchodilators. A better understanding of the pathobiology of COPD is critical for the development of novel therapies. In the present review, we have discussed the roles of oxidative/aldehyde stress, inflammation/immunity, and chromatin remodeling in the pathogenesis of COPD. An imbalance of oxidants/antioxidants caused by cigarette smoke and other pollutants/biomass fuels plays an important role in the pathogenesis of COPD by regulating redox-sensitive transcription factors (e.g., NF-κB), autophagy and unfolded protein response leading to chronic lung inflammatory response. Cigarette smoke also activates canonical/alternative NF-κB pathways and their upstream kinases leading to sustained inflammatory response in lungs. Recently, epigenetic regulation has been shown to be critical for the development of COPD because the expression/activity of enzymes that regulate these epigenetic modifications have been reported to be abnormal in airways of COPD patients. Hence, the significant advances made in understanding the pathophysiology of COPD as described herein will identify novel therapeutic targets for intervention in COPD
Data & Supplementary Material for Yao et al. (2024, 2026)
No full textFull datasets for Yao, Li, Li, and Chang (2024, "Perceiving the social meanings of creaky voice in Mandarin Chinese", Speech Prosody 2024) and Yao, Li, and Chang (2026, "Social perception of creaky voice in Mandarin Chinese: Everyone's gender matters", Humanities and Social Sciences Communications) in text format (.txt). Detailed explanations of each variable in the dataset, along with R analysis code and full model outputs, are provided in the HTML file (knitted R Markdown). The data analysis files include high-resolution, color versions of visualizations that appear in the papers, as well as supplementary visualizations
Ben jing xu shu yao
No full text[V.1-6]. 本經疏證 -- [v.7-9]. 本經續疏 -- [v.9-12]. 本經序疏要.[V.1-6]. Ben jing shu zheng -- [v.7-9]. Ben jing xu shu -- [v.9-12]. Ben jing xu shu yao.鄒澍學 ; 常州常年醫局校栞. 本經續疏 : 六卷 / 鄒澍學 ; 胡杰校栞. 本經序疏要 : 八卷 / 鄒澍學 ; 許恩溥校栞.綫裝 .框16.3x12.7公分, 11行22字, 小字雙行同. 白口, 左右雙邊, 單黑魚尾. 版心上鐫題名, 中鐫卷次, 下鐫葉次.第一冊書名頁刻"鄒閏安先生本經疏證十二卷續疏六卷本經序疏要八卷" ; 又有紅色戳記"常州麟玉山房發兌"《本經序疏要》卷八末刻"常郡韓文煥齋鐫". 並有湯用中道光己酉[1849]跋.《中國中醫古籍總目》(02456)著錄.鈐"莊兆祥印", "莊兆祥".Xian zhuang .Kuang 16.3 x 12.7 gong fen, 11 hang 22 zi, xiao zi shuang hang tong. Bai kou, zuo you shuang bian, dan hei yu wei. Ban xin shang juan ti ming, zhong juan juan ci, xia juan ye ci.Detailed notes in vernacular field only.Detailed notes in vernacular field only.Detailed notes in vernacular field only.Zou Shu xue ; Changzhou Chang nian yi ju jiao kan. Ben jing xu shu : liu juan / Zou Shu xue ; Hu Jie jiao kan. Ben jing xu shu yao : ba juan / Zou Shu xue ; Xu Enpu jiao kan.Qian "Zhuang Zhaoxiang yin", "Zhuang Zhaoxiang"
Nrf2 deficiency influences susceptibility to steroid resistance via HDAC2 reduction
Get PDFAbnormal lung inflammation and oxidant burden are associated with a significant reduction in histone deacetylase 2 (HDAC2) abundance and steroid resistance. We hypothesized that Nrf2 regulates steroid sensitivity via HDAC2 in response to inflammation in mouse lung. Furthermore, HDAC2 deficiency leads to steroid resistance in attenuating lung inflammatory response, which may be due to oxidant/antioxidant imbalance. Loss of antioxidant transcription factor Nrf2 resulted in decreased HDAC2 level in lung, and increased inflammatory lung response which was not reversed by steroid. Thus, steroid resistance or inability of steroids to control lung inflammatory response is dependent on Nrf2-HDAC2 axis. These findings have implications in steroid resistance, particularly during the conditions of oxidative stress when the lungs are more susceptible to inflammatory response, which is seen in patients with chronic obstructive pulmonary disease, asthma, rheumatoid arthritis, and inflammatory bowel disease
The Role of Trade Wind Surges in Tropical Cyclone Formations in the Western North Pacific
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