25 research outputs found
The performance of faecal immunochemical test and urinary volatile compounds in the detection of colorectal adenomas and their role in polyp surveillance : (FAST study)
Get PDFColorectal polyp surveillance plays a major role in the prevention of colorectal cancer. Non-invasive surveillance modalities, therefore, attract considerable attention.
In this study, the performance of FIT varied depending on the cut-off levels chosen. Overall, its sensitivity was higher at lower thresholds, whilst a steady decline was noted at higher cut-off levels. Higher specificity was observed at higher cut-off levels. FIT had shown a better performance in the detection of a high-risk finding. At the threshold of 10 ug/g faeces, the sensitivity and specificity of FIT for the detection of a high-risk finding were 0.54 (95% confidence interval (CI), 0.43 to 0.65) and 0.79 (95% CI, 0.73 to 0.84) respectively. Moreover, in our study, age, sex, proton pump inhibitor therapy, anticoagulation therapy, antiplatelet therapy and non-steroidal anti-inflammatory drugs did not have any effect on the performance of FIT.
The analysis of VOC demonstrated that a high-risk finding could be differentiated with the area under curve of 0.74 (sensitivity of 0.92 (95% CI, 0.86 to 0.97) and specificity of 0.62 (95% CI, 0.55 to 0.68). The combined performance of FIT and VOC, in a serial testing manner, was superior to either of those tests conducted alone.
The combination of FIT and VOC can be utilised in polyp surveillance, as a triage tool in risk-stratifying patients
Breath diagnostics in the era of SARS-CoV-2 – in clinical and research arena.
Get PDFThe emergence of the SARS-CoV-2 pandemic has transformed not just healthcare, but also the economic systems on a global scale. Despite significant efforts to contain the infection, it continues to spread. Stringent infection control measures have been taken to minimise the transmission between individuals and healthcare workers, especially those undertaking aerosols generating medical procedures. The uncertainties surrounding infection transmission through breath tests in particular, and to some extent faecal testing, will invariably cause concerns among both the patients and the healthcare workers. It is therefore pertinent that all of the necessary measures are adopted to minimise this risk of spreading. In this article, we summarise the physiology and virulence of SARS-CoV-2 and discuss the implications for breath testing (in both the clinical and research arena) as well as outlining methods to mitigate these risks
Additional file 1: of Colonic thickening on computed tomographyâdoes it correlate with endoscopic findings? A protocol for systematic review
No full textPRISMA-P (Preferred Reporting Items for Systematic review and Meta-Analysis Protocols) 2015 checklist: recommended items to address in a systematic review protocol*. (DOC 84.5 kb
A Systematic Review and Meta-Analysis: Volatile Organic Compound Analysis in the Detection of Hepatobiliary and Pancreatic Cancers
Get PDFBackground: Hepatobiliary cancers are notoriously difficult to detect, frequently leading to diagnosis in later stages of disease when curative treatment is not an option. The currently used biomarkers such as AFP (alpha-fetoprotein) and CA19.9 lack sensitivity and specificity. Hence, there is an unmet need for an alternative biomarker. Aim: To evaluate the diagnostic accuracy of volatile organic compounds (VOCs) for the detection of hepatobiliary and pancreatic cancers. Methods: A systematic review of VOCs’ use in the detection of hepatobiliary and pancreatic cancers was performed. A meta-analysis was performed using the software R. Heterogeneity was explored through meta-regression analysis. Results: A total of 18 studies looking at 2296 patients were evaluated. Pooled sensitivity and specificity of VOCs for the detection of hepatobiliary and pancreatic cancer were 0.79 (95% CI, 0.72−0.85) and 0.81 (97.5% CI, 0.76−0.85), respectively. The area under the curve was 0.86. Meta-regression analysis showed that the sample media used contributed to heterogeneity. Bile-based VOCs showed the highest precision values, although urine and breath are preferred for their feasibility. Conclusions: Volatile organic compounds have the potential to be used as an adjunct tool to aid in the early diagnosis of hepatobiliary cancers
Implementing an IGRA (interferon-gamma release assay) based TB screening pathway prior to starting biological treatments – Experience from a UK university hospital
No full textPTH-019 ‘missed’ oesophago- gastric cancers on gastroscopy: are we really missing them all?
No full text
Facilitating programming comprehension for novice learners with multimedia approach: A preliminary investigation
No full textPotential of Coffee Waste in Enzyme Production under Solid-State Fermentation using Penicillium sp
No full textThis Dissertation / Report is the outcome of investigation carried out by the creator(s) / author(s) at the department/division of Central Food Technological Research Institute (CFTRI), Mysore mentioned below in this page
P292 Proton pump inhibitors and faecal immunochemical tests for the detection of colorectal neoplasia in symptomatic-patients
No full text
