1,799 research outputs found
Effects of fluoxetine on 24h rhythms of melatonin and prolactin secretion in patients with premenstrual syndrome (PMS).
No full textTeaching abstract concepts in contemporary nursing through spirituality
No full textAuthor name used in this publication: Loretta Yuet Foon Chung2003-2004 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishedGreen (AAM
Sex differences in the prediction of the effectiveness of paroxetine for patients with major depressive disorder identified using a receiver operating characteristic curve analysis for early response [Corrigendum]
No full textTomita T, Norio YF, Sato Y, et al. Neuropsychiatr Dis Treat. 2014;10:599–606.On page 599, there is an error in the author list "Yasui-Furukori Norio" should read "Norio Yasui-Furukori".Read the original articl
Social Policy Study in Taiwan An Analysis of Postgraduate Degree Theses, 1990-2008
No full text[[abstract]]Welfare development in Taiwan has been accompanied by a significant growth of postgraduate programs after the 1990s. Yet, few previous papers have explored the changing academic studies in relation to policy development. Degree theses as an indicator of academic output should show the overall picture of shifts in social policy studies. We adopt secondary data analysis, based on the Dissertation and Thesis Abstract Database, which contains 2,089 degree theses from all of the 20 social work and social policy institutes in Taiwan. A three-dimensional framework is constructed to highlight important changes of theses in 1990-2008 and the implications to welfare development.[[note]]SSC
A critical study of the representation of women in the Shang dynasty through the lens of oracle bones and other written records = Cong wen zi cai liao kao cha Shang dai nü xing wen hua
No full textUnder the influence of Confucianism, “feebleness” is a keyword in discourse on the image of imperial Chinese women. They were bound by the “Three Obediences and Four Virtues” and duty to take care of a family. Surprisingly, the record shown on the Oracle Bones Inscriptions seems to illustrate a completely different image of Chinese women in the Shang dynasty – in addition to parenting, they were also part of the working force in society. Aside from agricultural production, they would also take part in important ritual performances. The most impressing phenomenon would be the women could go to battlefield to conquer against invasion at that time. These manifest a different dimension of women studies in ancient time. Hence, this study aims at a thorough investigation into women in Shang dynasty, based on different prevailing written records, including some secondary historical documents written after the Shang.
This research would first examine how matriarchy played an important role to or influenced Shang reign and the society. In this section, I will try to point out the association of Shang women with Mother Goddess and Totem culture, which might serve as the reason why women could enjoy a rather special status in Shang. This section will also highlight the relationship of xuan niao (玄鳥) and Shang women to indicate the possibility that the power and rights possessed by Shang women might be originated from their bird ancestors. A discussion of the close relationship between xuan niao and Shang women contributing to the special identity of women in Shang will be included in this part.
For the second section, some examples are cited from the oracle bones inscriptions to identify how Shang women actually engaged in the social activities, including agricultural production, preparation of battlefield, ritual performances, and giving birth. In this section, archaeological findings are also compiled in the studies to provide a more thorough picture of women in Shang. These records from the oracle bones inscriptions served as the powerful first hand sources to reveal women’s social responsibilities at that time.
For the third section, it is a focus on the study of the structure of oracles text itself – to bring to this study a critical dimension. The use of “Woman” character in the formation of the oracle bones text implies some special cultural meanings beyond. While these words are taken into account, the main concern is to manifest how their structures correlate with their representations. This chapter is an attempt to come up with a summary of findings based on the previous chapters. Clarifications and add-ons are also made upon the existing definitions of the words.published_or_final_versionChineseMasterMaster of Philosoph
Effects of iron overload on apoptosis and titin proteolysis in cardiomyocytes
No full textIron is one of the essential elements involved in various fundamental biological activities. However, excess iron may bypass the negative feedback regulatory systems, leading to the formation of iron overload. The increase of iron deposition generates cellular toxicity and subsequently damages vital organs. Primary and secondary iron overload are affecting patients worldwide. Iron overload cardiomyopathy is the primary cause of cardiac dysfunction and cardiovascular mortality in β-thalassaemia major patients. Current effective therapy includes chelation treatment with conventional and new iron chelators, while potential new therapies are currently under development.
The pathophysiology of iron overload cardiomyopathy remains unclear. Controversial findings on the mechanism of excessive iron entry into cardiomyocytes exist. Using novel real-time approach to trace iron entry into HL-1 cardiomyocytes, the only beating cardiac cell line with mature cardiac phenotype available currently, we visualized the patterns of iron entry following ferric iron incubation with and without ascorbate. Iron entry could be partly blocked by pretreatment with L-type calcium channel blockers but not T-type calcium channel blocker. Such blockage effect by L-type calcium channel blockers occurred in ferric iron overload. This finding suggested a role of L-type calcium channels for ferric iron uptake into cardiomyocytes under iron overload condition.
For the pathophysiology of iron cardiac toxicity, we assessed the iron overload induced apoptosis using both in vitro and in vivo approaches. The results demonstrated that iron-overloaded mouse HL-1 atrial cardiomyocytes and human embryonic stem cell derived ventricular cardiomyocytes underwent apoptosis via the mitochondria-mediated caspase-3 dependent pathway. Supportive data was found in iron-overloaded mouse myocardium by an increase in DNA fragmentation. However, despite the blockage of iron entry, L-type calcium channel blockers did not significantly prevent iron induced apoptosis in vitro.
The mechanism of cardiac contractile dysfunction caused by iron overload on cardiomyopathy has not yet been fully characterized. Given the central role of titin, the giant myofilament protein, as the main determinant in myocardial passive tension, stiffness, diastolic and systolic cardiac function, as well as myocardial twisting and untwisting motion, we investigated its expression in iron-overloaded cardiomyocytes in vitro and in vivo. Our results indicated that significant degradation of cardiomyocytes titin was induced by iron overload. This was associated with the cleavage at the elastic domain. Its potential upstream protease, calpain, was further identified to be activated under iron overload. The specific role of titin proteolysis in iron-overloaded cardiomyocytes merited further investigation.
The findings in this project provided new insights to the pathophysiology of iron overload cardiomyopathy, in terms of the route for iron entry, iron induced cardiac apoptosis, and titin proteolysis. Novel therapeutic approaches for prevention and treatment of iron overload cardiomyopathy can focus on inhibiting excessive iron uptake, as well as by targeting pathways involved in cardiac apoptosis and titin proteolysis.published_or_final_versionPaediatrics and Adolescent MedicineDoctoralDoctor of Philosoph
Search for missing charmonium states in B-meson decays
No full textThe recent progress in experiments at B-factories suggests an opportunity to search for the missing charmonium states eta'(c)(2(1)S(0)) and h(c)(1 P-1(1)). The feasibility of such a search in B-meson decays are discussed. (C) 2002 Elsevier Science B.V All rights reserved.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000176725100002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Physics, MultidisciplinarySCI(E)6ARTICLE1-26-1053
Connection between the closeness of classical orbits and the factorization of the radial Schrodinger equation
No full textIt is shown that the Runge-Lenz vector of a hydrogen atom is equivalent to the raising and lowering operators derived from the factorization of the radial Schrodinger equation. A similar situation exists for an isotropic harmonic oscillator. It is seen that there exists an intimate relation between the conserved quantities responsible for the closeness of classical orbits on the one side and the quantum-mechanical raising and lowering operators on the other side, which is physically connected with the dynamical symmetry of the system considered. Some discussions are made about the factorization of a one-dimensional system. [S1050-2947(98)06308-2].http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000075386200016&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701OpticsPhysics, Atomic, Molecular & ChemicalSCI(E)5ARTICLE2862-8685
MOLECULAR LINE STUDIES OF DENSE CORE MOTIONS
No full textMolecular lines have revealed various supporting motions in dense cores. Line widths and emission region sizes of NH3 and CS in the same kind of cores or of the same line in cores with or without sources are different and can not be explained with the line width- size relationship. Outflows in dense cores show rich characteristics which can account for the NH3 emission difference between the two kinds of the cores; CS emission is consistent with the chemical effects in shocked regions. Rotation exists in both kinds of cores and may be related to the observed polarities and collimations of outflows.Astronomy & AstrophysicsSCI(E)0ARTICLE150217-22
A mathematical model for describing the mechanical behaviour of root canal instruments
No full textZhang EW, Cheung GSP, Zheng YF. A mathematical model for describing the mechanical behaviour of root canal instruments. International Endodontic Journal, 44, 72-76, 2011.Aim The purpose of this study was to establish a general mathematical model for describing the mechanical behaviour of root canal instruments by combining a theoretical analytical approach with a numerical finite-element method.Method Mathematical formulas representing the longitudinal (taper, helical angle and pitch) and cross-sectional configurations and area, the bending and torsional inertia, the curvature of the boundary point and the (geometry of) loading condition were derived. Torsional and bending stresses and the resultant deformation were expressed mathematically as a function of these geometric parameters, modulus of elasticity of the material and the applied load. As illustrations, three brands of NiTi endodontic files of different cross-sectional configurations (ProTaper, Hero 642, and Mani NRT) were analysed under pure torsion and pure bending situation by entering the model into a finite-element analysis package (ANSYS).Results Numerical results confirmed that mathematical models were a feasible method to analyse the mechanical properties and predict the stress and deformation for root canal instruments during root canal preparation.Conclusions Mathematical and numerical model can be a suitable way to examine mechanical behaviours as a criterion of the instrument design and to predict the stress and strain experienced by the endodontic instruments during root canal preparation. © 2010 International Endodontic Journal.link_to_subscribed_fulltex
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