40,859 research outputs found
Polaroid photo of Dr Chan Khye Meng
No full textPhotograph of sepia tone polaroid depicting Dr Chan, wearing white doctor's vest behind his desk. Taken by Lloyd Chan (his son) on March 1974. The top of the photo indicates Mar 74. Lloyd has an interest in photography and documented the final days of the clinic in June 2019. Dimensions: 6.2 x 8.7 cm. Accession number: 2019-0093</div
Not like my mother : truth and the author in creative nonfiction
No full textThis exegesis examines how a writer can effectively negotiate the relationship between author, character, fact and truth, in a work of Creative Nonfiction. It was found that individual truths, in a work of Creative Nonfiction, are not necessarily universal truths due to individual, cultural, historical and religious circumstances. What was also identified, through the examination of published Creative Nonfiction, is a necessity to ensure there are clear demarcation lines between authorial truth and fiction. The Creative Nonfiction works examined, which established this framework for the reader, ensured an ethical relationship between author and audience. These strategies and frameworks were then applied to my own Creative Nonfiction
My Faithful Friend
No full textThe author submitted this entry in the Open Verse Poetry category (Amateur division) for the 2024 On My Own Time (OMOT) Art Show.This was inspired from a situation that one of my family friend was going through. Prayers were offered while looking to God for an answer. This was my reflection of the situation and trust in God
Metabolizing enzyme toxicology assay chip (MetaChip) for high-throughput microscale toxicity analyses
No full textThe clinical progression of new chemical entities to pharmaceuticals remains hindered by the relatively slow pace of technology development in toxicology and clinical safety evaluation, particularly in vitro approaches, that can be used in the preclinical and early clinical phases of drug development. To alleviate this bottleneck, we have developed a metabolizing enzyme toxicology assay chip (MetaChip) that combines high-throughput P450 catalysis with cell-based screening on a microscale platform. The MetaChip concept is demonstrated by using sol-gel encapsulated P450s to activate the prodrug cyclophosphamide, which is the major constituent of the anticancer drug Cytoxan, as well as other compounds that are activated, by P450 metabolism. The MetaChip provides a high-throughput microscale alternative to currently used in vitro methods for human metabolism and toxicology screening based on liver slices, cultured human hepatocytes, purified microsomal preparations, or isolated and purified P450s. This technology creates opportunities for rapid and inexpensive assessment of ADME/Tox (absorption, distribution, metabolism, excretion/toxicology) at very early phases of drug development, thereby enabling unsuitable candidates to be eliminated from consideration much earlier in the drug discovery process
Integrative Body-Mind-Spirit Social Work: An Empirically Based Approach to Assessment and Treatment
No full textThe second edition represents a major revision from the original book, featuring numerous case studies and a robust companion website including demonstration videos and reproducible client handouts
Novel Excerpt: My Name Is Sweet Thing , Part 1 'Whose Little Girl Am I?'
No full textThe night I turned sixteen � in 1979 � I dreamt I swallowed all of my teeth, and Aunt Winnie said it meant disgrace was coming to the family. I forced a laugh but exchanged a concerned look with my cousin, Bernice, as a feeling like ice spread through my abdomen because Aunt Winnie was never wrong
My Thyme
No full textThe author submitted this entry in the AI Literature category (Amateur division) for the 2024 On My Own Time (OMOT) Art Show.This piece was inspired by the clock ticking away while I was cooking. Reading the poem out loud should make the connection clear. I used AI assistance for rhyme and meter
The Winter of My Soul
No full textThe author submitted this entry in the Open Verse Poetry category (Amateur division) for the 2023 On My Own Time (OMOT) Art Show.Describes the emptiness of love lost and the desire to find it again
My Queen
No full textThe author submitted this entry in the Open Verse Poetry category (Amateur division) for the 2024 On My Own Time (OMOT) Art Show.My inspiration for writing the poem "My Queen" was to model writing elegy poetry for my 7th grade ELA students. My mother had recently passed away and I decided it would be an honorable memory. I didn't have a lot of time to fully process the reality of life without her nor really grieve, because I had a main role in preparing as well as participating in her funeral services, and afterwards, I could not take more time off from work. Writing this poem was very therapeutic for me, and even more so when I read it aloud in class to my students. When I finished reading it, the entire class gave me a standing ovation and many of them (including me) were visibly filled with raw emotions (tears). When they completed their elegy poetry, it was very apparent that my previous moment of transparency had quite a positive influence on their commitment to produce amazing heart-warming poetry
Design, synthesis and functionalization of organic and metal-containing [pi]-conjugated push-pull chromophores : from photophysics to organic electronic application studies
No full textFully beta- and meso-substituted free base porpyhrins and metalloporphyrins have been successfully synthesized and characterized. Different types of substituents with various electronic nature have been successfully introduced onto the beta- and meso-positions of the porphyrin core. One of the metalloporphyrins has been structurally determined by X-ray crystallography, revealing a ruffling conformation. The photophysical, electrochemical and thermal properties of this series of porphyrins were studied in detail. Some of the target zinc(II) porphyrin complexes were found to be emissive in solution state with emission bands in the near-infrared region. The potential application of utilizing metalloporphyrins as active materials in organic resistive memory have been explored. Devices based on a nickel(II) porphyrin with push and pull beta-substituents were found to exhibit ternary resistive memory behavior while binary memory behavior was observed for devices prepared from push only and pull only counterparts.
A new class of axial- and peripheral-substituted boron subphthalocyanines has been designed and synthesized. Attachments of various donor-acceptor types of substituents on axial and peripheral positions have been achieved to modulate their molecular properties intrinsically. Their photophysical and electrochemical properties were found to be sensitive to the position of the functionalization. Axially-substituted boron subphthalocyanines were found to show efficient energy transfer from the boron subphthalocyanine core to the axial substituents. Distinct excited-state photophysical properties were observed for selected axial- and peripheral-substituted boron subphthalocyanines by using nanosecond and femtosecond transient absorption spectrocopy. While characterisic triplet-triplet transient absorptions of the boron subphthalocyanine core were shown by axially-substituted target compounds in the nanosecond time regime, peripherally substituted boron subphthalocyanines were found to show solvent-dependent photo-induced electron transfer from the peripheral substituents on the boron subphthalocyanine core in the femtosecond time range. In the examination of resistive memory properties, devices prepared from an axially-substituted derivative were found to exhibit multistate memory property while binary memory devices were obtained from a peripherally-substituted derivative.
Other than nature-inspired macrocyclic compounds, a new class of donor-acceptor bis-enediyne-containing pi-conjugated organic small molecules has been prepared and characterized. Their photophysical, electrochemical and thermal properties were examined. The excited state properties of this class of compound were investigated by femtosecond transient absorption spectrocopy. Selected representatives showed positive transient absorption signals at ca. 650 nm, which were tentatively assigned as the formation of cation radicals of the conjugated bis-enediyne backbones. The potential application of this class of compounds as donor materials in solution processable bulk-heterojunction solar cells has been explored by serving as co-donors with poly(3 hexylthiophene). By using [6,6]-phenyl-C61-butyric acid methyl ester as electron acceptor, a power conversion efficiency of up to 2.63 % was achieved by doping 10 wt % of a derivative into poly(3 hexylthiophene). In addition to the optoelectronic properties, the exploration of the resistive memory behavior on selected derivatives has also been attempted. Binary logic was observed for devices based on these derivatives.published_or_final_versionChemistryDoctoralDoctor of Philosoph
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