132 research outputs found
The effect of transcranial direct current stimulation in changing resting-state functional connectivity in patients with neurological disorders : a systematic review
No full text202104 bcvcVersion of RecordOthersP0014087PublishedC
Effects of transcranial direct current stimulation (tDCS) in the normalization of brain activation in patients with neuropsychiatric disorders : a systematic review of neurophysiological and neuroimaging studies
No full text202105 bcvcVersion of RecordOthersP0014087PublishedC
Differential mirror neuron system (MNS) activation during action observation with and without social-emotional components in autism : a meta-analysis of neuroimaging studies
No full text202011 bcrcVersion of RecordOthersP0000464PublishedC
The functional brain networks activated by music listening : a neuroimaging meta-analysis and implications for treatment
No full text202206 bcchAccepted ManuscriptOthersZE65PublishedGreen (AAM
Strategies to engage people with dementia and their informal caregivers in dyadic intervention : a scoping review
No full text202103 bcrcAccepted ManuscriptSelf-fundedPublishedGreen (AAM
Prognosis and treatment effects of HIV-associated talaromycosis in a real-world patient cohort.
No full textTalaromycosis is a leading cause of AIDS-associated opportunistic infections and death in Southeast Asia. We have recently shown in the Itraconazole versus Amphotericin for Talaromycosis (IVAP) trial that induction therapy with amphotericin B reduced mortality over 24 weeks, but not during the first 2 weeks. Antifungal treatment effects in real-world settings have not been rigorously evaluated. Using data obtained from patient records at the Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam from 2004 to 2009, we first developed a prognostic model using Bayesian logistic regression to identify predictors of death. Second, we developed a causal model using propensity score matching to assess the treatment effects of amphotericin B and itraconazole. Our prognostic model identified intravenous drug use (odds ratio [OR] = 2.01), higher respiratory rate (OR = 1.12), higher absolute lymphocyte count (OR = 1.62), a concurrent respiratory infection (OR = 1.67) or central nervous system infection (OR = 2.66) as independent predictors of death. Fever (OR = 0.56) was a protective factor. Our prognostic model exhibits good in-sample performance and out-of-sample validation, with a discrimination power of 0.85 and 0.91, respectively. Our causal model showed no significant difference in treatment outcomes between amphotericin B and itraconazole over the first 2 weeks (95% credible interval: 0.62, 2.50). Our prognostic model provides a simple tool based on routinely collected clinical data to predict individual patient outcome. Our causal model shows similar results to the IVAP trial at 2 weeks, demonstrating an agreement between real-world data and clinical trial data
Effects of working memory load on frontal connectivity in children with autism spectrum disorder : a fNIRS study
No full text202212 bckwVersion of RecordPublishedC
Realization of Thermally Stimulated Delayed Phosphorescence in Arylgold(III) Complexes and Efficient Gold(III) Based Blue-Emitting Organic Light-Emitting Devices
No full textTo address and overcome the difficulties associated with the increased reactivity and susceptibility of blue emitters to deactivation pathways arising from the high-lying triplet excited states, we have successfully demonstrated an innovative strategy of harvesting triplet emission via the “thermally stimulated delayed phosphorescence” mechanism, where thermal up-conversion of excitons from the lower-energy triplet excited states (T1) to higher-energy triplet excited states (T1′) are observed to generate blue emission. The lower-lying T1 excited state could serve as a mediator to populate the emissive T1′ state by up-conversion via reverse internal conversion, which could enhance the
photoluminescence quantum yield by over 20-folds. Organic light-emitting devices with respectable external quantum efficiencies of up to 7.7 % and sky-blue emission with CIE coordinates of (0.17, 0.37) have been realized. The operational stability for the device based on complex 1 has also been explored, and the device is found to show fairly respectable lifetime. This work opens up a new avenue to the design and synthesis of blue phosphorescent emitters.
References: 1. M.-C. Tang, M.-Y. Leung, S.-L. Lai, M. Mg, M.-Y. Chan, V. W.-W. Yam, J. Am.
Chem. Soc., 2018, 140, 13115.
†M.-C.T. and M.-Y.L. contributed equally to this work
Toe tap test (TTT) for assessing people with chronic stroke
No full textBACKGROUND AND RATIONALE: Impaired ankle control is common in stroke survivors (Ng & Hui-Chan 2012, 2013). Ankle control, including ankle dorsiflexion and plantarflexion, is important in regaining normal gait pattern after stroke. Indeed, ankle dorsiflexor strength was independently associated with the walking endurance (Ng & Hui-Chan 2013) and functional mobility (Ng & Hui-Chan2013) of stroke survivors. In order to reflect changes in ankle control during the rehabilitation process, a reliable, valid and comprehensive measurement tools for assessing ankle control are definitely needed. Toe tap test (TTT) was initially introduced as a simple toetapping test to determine speed of ankle control in healthy adults (Kent-Braun & Ng 1999). Each subject was required to sit with knee and hip at 90 degrees of flexion, and maintain their heel on floor. Then, subjects were instructed to tap the floor as rapid as possible for 10 seconds. The objectives of this study were to investigate: (1) the interrater and test-retest reliability, (2) the correlation of TTT counts with other measures of stroke-specific impairments (3) minimal detectable change (MDC) of TTT counts. METHODS: It was a cross-sectional study with 37 subjects with chronic stroke. The main outcome measured included: TTT counts, Fugl-Meyer Lower Extremity assessment (FMA-LE); ankle muscle strength; Five Times Sit-to-Stand Test (FTSTS) times; Berg Balance Scale (BBS) and Timed ‘Up and Go’ test (TUG) scores. RESULTS: Excellent intra-rater and test-retest reliability (ICC = 0.725–0.995)) of TTT counts were found. The TTT counts of paretic legs were significantly associated with FMA-LE, ankle dorsiflexor and plantarflexor strength, BBS score, FTSTS completion time and TUG score. The 95% MDC of TTT counts was 8.7 counts and 12.6 counts of the paretic and non-paretic legs, respectively. CONCLUSION: The TTT counts is a reliable and valid measurement tool for assessing the ankle control of subjects with chronic stroke.link_to_OA_fulltex
Neural substrates underlying effortful control deficit in autism spectrum disorder : a meta-analysis of fMRI studies
No full text202403 bcvcVersion of RecordothersHong Kong Polytechnic UniversityPublishedC
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