613 research outputs found
City levels: weaving urban flows.
No full textChan Chun Kit Kevin."Architecture Department, Chinese University of Hong Kong, Master of Architecture Programme 2004-2005, design report."Includes bibliographical references.Thesis StatementPrecedents of similar phenomenon in Hong KongRedevelopment Policy Highlights of theUrban Renewal AuthoritySite Study - Kowloon CitySite Study - CentralRecent redevelopment strategiesStrategies on LinkageSchematic strategiesSite study and analysisSite photosSite development under different strategiesPreliminary DesignDesign developmentDetailed design drawings and presentatio
Signal Processing for Optical Communication System Assisted by Computer Vision Techniques
No full textWe review the recent progress on the application of image processing techniques to optical communication systems. The focus is placed mainly on the implementation complexity and performance of the techniques for optical performance monitoring and the compensation of common phase error. We also briefly introduce several applications where machine learning algorithms could be beneficial to fiber-optic transmission system
CUHK electronic theses & dissertations collection
No full textby Chun-kit Chan.Thesis (Ph.D.)--Chinese University of Hong Kong, 1997.Includes bibliographical references (p. 143-158).Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.Mode of access: World Wide Web
Computational studies on biological membranes and viral capsids
No full textSubmission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-11-11 without embargo termsThe student, Chun Kit Chan, accepted the attached license on 2022-01-20 at 23:39.The student, Chun Kit Chan, submitted this Dissertation for approval on 2022-01-20 at 23:49.This Dissertation was approved for publication on 2022-02-11 at 14:41.DSpace SAF Submission Ingestion Package generated from Vireo submission #17480 on 2022-11-11 at 13:04:08Biological membranes are ubiquitous and often involved in complex processes. A well-known example are bioenergetic membranes, which use an array of integral membrane proteins and their complexes, small molecules, as well as soluble proteins to produce adenosine triphosphate (ATP), the molecular currency of energy in the cell for metabolism. This production of ATP requires transmembrane gradient of protons, which is generated by coupling proton translocation across the membrane to an electron transport chain. The electron transport chain employs small, lipophilic molecules and, often, small, soluble proteins to shuttle electrons between the integral membrane proteins. Disruption of electron shuttling mediated by these small molecules and/or soluble proteins frustrates the electron transport chain and subsequently prohibits the generation of ATP. Thus, elucidating the interaction between these electron shuttling agents and their redox partners is key to understanding conditions that facilitate/hinder cellular energy transduction. The diffusion of the electron shuttles is a stochastic pro- cess and therefore susceptible to environmental variations, including fluctuations in the environmental salinity, changes in the local lipid composition, and conformational changes of the redox partners. Also, the time span involved in their diffusion can range from a few hundred nanoseconds to several micro/milliseconds. Thus, computational techniques that can account for the important atomic details of electron shuttles and their redox partners, and at the same time can simulate their stochastic diffusion on relevant timescales are required for properly capture their mechanism. Molecular dynamics (MD) and Brownian dynamics (BD) are tools whose combination may satisfy these criteria. Employing MD and/or BD simulations, I have characterized the inter- actions between three commonly studied electron shuttles and their redox partners. These include cytochrome c2 (cyt. c2), quinones, and cytochrome c (cyt. c), and their redox partners cytochrome bc1 complex (bc1), cy- tochrome bo3 (cyt. bo3), and the yeast supercomplex (SC). In the first case, I illustrate the involvement of anionic lipids in cyt. c2 - bc1 interactions, and how sensitive it is to the environmental salinity whose variation can potentially enhance cyt. c2 - bc1 association when the redox states of the two proteins are complementary. In the second case, I demonstrate the role of a particular transmembrane helix of cyt. bo3 in stabilizing the protein interaction with quinones and in facilitating proton translocation from the cofactors to the bulk solu- tion. In the third case, I show the role of a flexible subunit in the SC in alleviating undesirable impacts from lipids on the diffusion of cyt. c as well as in regulating the affinity between cyt. c and individual subunits of SC during the cyt. c - mediated electron transport. Finally, I have used a combined MD/BD approach to study viral capsids. I have examined platelet factor 4 (PF4), which interacts with the capsid of ChAdOx1, a viral vector used in vaccines produced by AstraZeneca (AZ) to combat the SARS-CoV-2 virus. I illustrate that PF4 interaction with ChAdOx1 is electrostatically driven, and supported by their geometric complementarity. I have also characterized residues in ChAdOx1 that serve as hotspots for PF4 - ChAdOx1 association. With the help of experimental virologists, we use the information to devise strategies to interrupt PF4 - ChAdOx1 association and to further reduce the chance for the rare blood-clotting complication of AZ vaccines
Zhi hun he zai shuang ceng mo zhong de fen zi dong li xue mo ni
No full textHong, Chun Kit = 脂混合在雙層膜中的分子動力學模擬 / 洪俊傑.Thesis M.Phil. Chinese University of Hong Kong 2014.Includes bibliographical references (leaves 59-66).Abstracts also in Chinese.Title from PDF title page (viewed on 16, November, 2016).Hong, Chun Kit = Zhi hun he zai shuang ceng mo zhong de fen zi dong li xue mo ni / Hong Junjie
Supplemental Material, sj-docx-1-ptd-10.1177_08968608221110491 - Predictors and prognostic significance of persistent fluid overload: A longitudinal study in Chinese peritoneal dialysis patients
No full textSupplemental Material, sj-docx-1-ptd-10.1177_08968608221110491 for Predictors and prognostic significance of persistent fluid overload: A longitudinal study in Chinese peritoneal dialysis patients by Jack Kit-Chung Ng, Bonnie Ching-Ha Kwan, Gordon Chun-Kau Chan, Kai Ming Chow, Wing Fai Pang, Phyllis Mei-Shan Cheng, Chi Bon Leung, Philip Kam-Tao Li and Cheuk Chun Szeto in Peritoneal Dialysis International</p
A Smart Healthcare Kit for Home Healthcare
No full textAuthor Contributions: Writing—original draft preparation, Chun-Yang Chou, and Chun-Hung Chou; writing—review and editing, Chun-Yang Chou, Ding-Yang Hsu and Chun-Hung Chou All authors have read and agreed to the published version of the manuscript.</p
sj-docx-1-isp-10.1177_00207640231161301 – Supplemental material for Double stigma in mental health service use: Experience from ethnic minorities in Hong Kong
No full textSupplemental material, sj-docx-1-isp-10.1177_00207640231161301 for Double stigma in mental health service use: Experience from ethnic minorities in Hong Kong by Suen Yi Nam, Wong Yik Chun, Wong Tak Hing Michael, Chan Kit Wa Sherry, Hui Lai Ming Christy, Lee Ho Ming Edwin and Chen Yu Hai Eric in International Journal of Social Psychiatry</p
Supplemental Material, AD-short - Dealing With Death Taboo: Discussion of Do-Not-Resuscitate Directives With Chinese Patients With Noncancer Life-Limiting Illnesses
No full textSupplemental Material, AD-short for Dealing With Death Taboo: Discussion of Do-Not-Resuscitate Directives With Chinese Patients With Noncancer Life-Limiting Illnesses by Hon-Wai Benjamin Cheng, Pui-Shan Karen Shek, Ching-Wah Man, Oi-Man Chan, Chun-Hung Chan, Kit-Man Lai, Suk-Ching Cheng, Koon-Sim Fung, WK Lui, Carman Lam, Yuen-Kwan Ng, Wan-To Wong, and Cherry Wong in American Journal of Hospice and Palliative Medicine®</p
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