39 research outputs found
CYY-1/Cyclin Y and CDK-5 Differentially Regulate Synapse Elimination and Formation for Rewiring Neural Circuits
No full textSummaryThe assembly and maturation of neural circuits require a delicate balance between synapse formation and elimination. The cellular and molecular mechanisms that coordinate synaptogenesis and synapse elimination are poorly understood. In C. elegans, DD motoneurons respecify their synaptic connectivity during development by completely eliminating existing synapses and forming new synapses without changing cell morphology. Using loss- and gain-of-function genetic approaches, we demonstrate that CYY-1, a cyclin box-containing protein, drives synapse removal in this process. In addition, cyclin-dependent kinase-5 (CDK-5) facilitates new synapse formation by regulating the transport of synaptic vesicles to the sites of synaptogenesis. Furthermore, we show that coordinated activation of UNC-104/Kinesin3 and Dynein is required for patterning newly formed synapses. During the remodeling process, presynaptic components from eliminated synapses are recycled to new synapses, suggesting that signaling mechanisms and molecular motors link the deconstruction of existing synapses and the assembly of new synapses during structural synaptic plasticity
Two Cyclin-Dependent Kinase Pathways Are Essential for Polarized Trafficking of Presynaptic Components
No full textSummaryPolarized trafficking of synaptic proteins to axons and dendrites is crucial to neuronal function. Through forward genetic analysis in C. elegans, we identified a cyclin (CYY-1) and a cyclin-dependent Pctaire kinase (PCT-1) necessary for targeting presynaptic components to the axon. Another cyclin-dependent kinase, CDK-5, and its activator p35, act in parallel to and partially redundantly with the CYY-1/PCT-1 pathway. Synaptic vesicles and active zone proteins mostly mislocalize to dendrites in animals defective for both PCT-1 and CDK-5 pathways. Unlike the kinesin-3 motor, unc-104/Kif1a mutant, cyy-1 cdk-5 double mutants have no reduction in anterogradely moving synaptic vesicle precursors (SVPs) as observed by dynamic imaging. Instead, the number of retrogradely moving SVPs is dramatically increased. Furthermore, this mislocalization defect is suppressed by disrupting the retrograde motor, the cytoplasmic dynein complex. Thus, PCT-1 and CDK-5 pathways direct polarized trafficking of presynaptic components by inhibiting dynein-mediated retrograde transport and setting the balance between anterograde and retrograde motors
Examining the role of attention deficits in the social problems and withdrawn behavior of children with sluggish cognitive tempo symptoms
No full text202110 bcvcVersion of RecordPublishedC
Repeated tactile stimulation promotes hippocampal neurogenesis and reduces depression-like behaviors
No full text2015-2016 > Other Outputs > Other outputsNot applicableCopyright retained by autho
Simplified analytic formulae for magneto-optical Kerr effects in ultrathin magnetic films
No full textExpressions are presented for various magneto-optical Kerr effects in the ultrathin film limit with arbitrary magnetization direction by considering the multiple reflections within an optically thin film. The Kerr effect of p- and s-polarization consists of products of two factors: the prefactor, dependent only on the optical parameters of the system, and the main factor of the polar Kerr effect for normal incidence in the ultrathin limit. (C) 1999 Elsevier Science B.V. All rights reserved.This work was supported by the Creative Research Initiatives of the Ministry of Science and Technology of Korea, and
one author (CYY) wishes to acknowledge the financial support of the Korea Research Foundation made in program
Year 1997, and the hospitality of Argonne National Laboratory. Argonne was supported by the US Department of
Energy, BES-Material Science, under contract No. W-31-109-ENG-38
Behavioural and autonomic regulation of response to sensory stimuli among children : a systematic review of relationship and methodology
No full text2017-2018 > Academic research: refereed > Publication in refereed journal201811_a bcma; 201808 bcrcVersion of RecordPublishedC
Event-related potential responses of individuals with Autism spectrum development to atypical auditory processing-a narrative review
No full text202505 bcwcVersion of RecordOthersInnovation and Technology Fund (ITF) of Hong Kong matching with Innovation Technology Company Limited; Peter T. C. Lee Endowed Professorship fundPublishedSpringer Nature (2025)T
Migration influences on the allostatic load of children : systematic review protocol
No full text202012 bcrcVersion of RecordPublishedC
Hamiltonian simulation with optimal sample complexity
No full text© 2017 Author(s). We investigate the sample complexity of Hamiltonian simulation: how many copies of an unknown quantum state are required to simulate a Hamiltonian encoded by the density matrix of that state? We show that the procedure proposed by Lloyd, Mohseni, and Rebentrost [Nat. Phys., 10(9):631-633, 2014] is optimal for this task. We further extend their method to the case of multiple input states, showing how to simulate any Hermitian polynomial of the states provided. As applications, we derive optimal algorithms for commutator simulation and orthogonality testing, and we give a protocol for creating a coherent superposition of pure states, when given sample access to those states. We also show that this sample-based Hamiltonian simulation can be used as the basis of a universal model of quantum computation that requires only partial swap operations and simple single-qubit states
