2,231 research outputs found
Toponymical lexics in the pre-war period of A.T. Tvardovskiy’s creative work
No full textThe pre-war period (1926-1940) of A.T. Tvaedovskiy’s creative work, the great poet of the 20yh century, born in the Smolensk Region, is a period of his rising as an insuperable master of word, a people’s tribune, the time when the main traits of his poetry were developed and when his formation as a founder of the Smolensk Poetic School occurred. One of the central themes of the SPS poets, and first of all, A.T. Tvardovskiy himself, was the theme of “the minor” and “the big”. Motherland, which was materialized in significant motives through a system of toponyms. i.e. the names of geograpphical places. The article analyzes a system of macro- and mictrotoponyms and demonstrates their part in revealing of the thematical content of numerous pre-war poems (A Trip to Zagorye, 1939, Station Pochinok, 1936, and others), as well the first epical poem of the author Strana Muraviya (1936)
Activatory and inhibitory Fcy receptors augment rituximab-mediated internalization of CD20 independent of signaling via the cytoplasmic domain
No full textType I anti-CD20 mAb such as rituximab and ofatumumab engage with the inhibitory Fc?R, Fc?RIIb on the surface of B cells, resulting in immunoreceptor tyrosine-based inhibitory motif (ITIM) phosphorylation. Internalization of the CD20·mAb·Fc?RIIb complex follows, the rate of which correlates with Fc?RIIb expression. In contrast, although type II anti-CD20 mAb such as tositumomab and obinutuzumab also interact with and activate Fc?RIIb, this interaction fails to augment the rate of CD20·mAb internalization, raising the question of whether ITIM phosphorylation plays any role in this process. We have assessed the molecular requirements for the internalization process and demonstrate that in contrast to internalization of IgG immune complexes, Fc?RIIb-augmented internalization of rituximab-ligated CD20 occurs independently of the Fc?RIIb ITIM, indicating that signaling downstream of Fc?RIIb is not required. In transfected cells, activatory Fc?RI, Fc?RIIa, and Fc?RIIIa augmented internalization of rituximab-ligated CD20 in a similar manner. However, Fc?RIIa mediated a slower rate of internalization than cells expressing equivalent levels of the highly homologous Fc?RIIb. The difference was maintained in cells expressing Fc?RIIa and Fc?RIIb lacking cytoplasmic domains and in which the transmembrane domains had been exchanged. This difference may be due to increased degradation of Fc?RIIa, which traffics to lysosomes independently of rituximab. We conclude that the cytoplasmic domain of Fc?R is not required for promoting internalization of rituximab-ligated CD20. Instead, we propose that Fc?R provides a structural role in augmenting endocytosis that differs from that employed during the endocytosis of immune complexes
Efficient implementation of the domain-integrated field relations method for quasi-static magnetic fields
No full textAuthor accepted manuscript of the 17th Annual Review of Progress in Applied Computational Electromagnetics, Monterey, pp. 337-344, 19 Mar 2001 → 23 Mar 2001Electrical Engineering, Mathematics and Computer Scienc
Kinetics of epoxy-asphalt oxidation
No full textIn-depth understanding of the temperature effect on oxidative aging in epoxy-asphalt blends is needed to enable accurate predictions on material response through their service life. Details of the significance of developing prediction models and tools on oxidative aging of pavement materials are presented in a companion paper (Apostolidis et al., Oxidation Simulation of Thin Bitumen Film. AM3P). In this research, the chemical compositional changes of epoxy modified asphalt binders, with and without filler, were analysed after oven-conditioning by means of Fourier transform infrared (FTIR) spectroscopy. With the carbonyl and sulfoxide compounds as aging indices, the sensitivity of chemical compositional changes of bituminous and epoxy-based systems due to the applied temperatures was observed.Accepted Author ManuscriptPavement Engineerin
Constraint Propagation and Reverse Multi-Agent Learning
No full textThe development of multi-agent reinforcement learning has been largely driven by the question of how to design learning algorithms to reach some particular notion of optimality of strategies, e.g. Nash equilibria. The set of optimal strategies is not known before the execution of the learning algorithm,however we can often immediately identify a set of clearly undesirable outcomes. Therefore, we propose to consider a dual problem: given a collection of agent algorithms and a collection of unwanted strategy profiles, can one identify a setof starting strategies that invariably lead there? This leads us to study the algorithmic problem of backpropagation of con-straints defining the forbidden region by learning dynamics,through the lens of set-valued maps and interval arithmetics.Accepted author manuscriptInteractive Intelligenc
Signal Integrity in Pulse-train Excited Array Antennas in Time and Space - A Full TD Analysis
No full textSignal integrity in the far-field radiation from pulse-train excited array antennas is studied via full timedomain instruments. The disturbance in the received signal is related to the fidelity factor. At any point in our analysis, the disturbance is evaluated based on a reduced, well defined set of parameters: pulse parameters and pulse repetition rate – temporal dependence, and elementary radiator location – spatial dependence. Their effect is examined by means of illustrative numerical experiments. These results are expedient for enhancing the detectability of the signals radiated by pulse-train excited array antennas, as needed in wireless digital transfer.Accepted author manuscriptEEMS - GeneralTera-Hertz Sensin
Wavefields and reciprocity: Proceedings of a symposium held in honour of Professor dr. A.T. de Hoop, November 20-21, 1996, Delft, the Netherlands
No full textElectrical Engineering, Mathematics and Computer Scienc
A time-domain finite-element method for the computation of three-dimensional acoustic wave fields in inhomogeneous fluids and solids
No full textElectrical Engineering, Mathematics and Computer Scienc
Transient diffusive electromagnetic fields in layerd anisotropic media
No full textElectrical Engineering, Mathematics and Computer Scienc
Scattering of electromagnetic waves by a class of waveguide discontinuities
No full textElectrical Engineering, Mathematics and Computer Scienc
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