237 research outputs found
Unravelling determinants and consequences of kidney function decline: A population-based approach
Full text linkThe high and increasing burden of the age-related condition chronic kidney disease (CKD) illustrates the need for improving the prediction and prevention of this impactful disease. In order to achieve this, there is a need for a better characterization of kidney function decline and for unravelling determinants of kidney function decline in the general population. In addition, kidney function and kidney function decline may be an important determinant of other non-communicable diseases which are related to ageing populations. Hence, the main aim of this thesis is to obtain insights into the determinants and effects of kidney function in the general population
A Step Forward in Understanding the Relevance of Genetic Variation in Type 2 Deiodinase
No full textThis article involves the study by Castagna et al. published in this issue of the Journal of Clinical Endocrinology & Metabolism on the association and functional analyses of genetic variation in DIO2.</jats:p
Glandula Thyreoidea et Senescens
Full text linkThyroid hormone action is crucial for the function of virtually all organs and tissues, but transport and metabolism of thyroid hormone is organ- and cell specific. Thyroid dysfunction is very common in the general population and prevalence can be up to 20% in elderly. Due to the large variation in clinical presentation and general absence of symptom specificity, the definition of thyroid dysfunction is predominantly biochemical, defined by the serum thyroid-stimulating hormone (TSH) and free thyroxine (FT4). This is despite the fact that thyroid diseases are associated with several clinical long-term consequences such as risk cardiovascular disease and dementia.
Because clinical thyroid disease is generally treated, long-term consequences of thyroid dysfunction have been mainly studied in the context of subclinical thyroid disorders. Some of these associations with mainly cardiovascular disease have also shown to extend within the currently defined reference ranges. Therefore a debate concerning the accuracy and usefulness in terms of clinical care and prevention of the reference ranges has emerged.
The aim of this thesis was to study the association of thyroid function, both TSH and FT4, with cardiovascular, neurological and other diseases of older age, beyond the current categorization for thyroid function and dysfunction. We hypothesized that risk of disease is not restricted to statistically defined reference ranges of thyroid function but represent a continuum of risk and as such also extends within these reference ranges
Response by Chaker et al to Letter Regarding Article, “Thyroid Function and Sudden Cardiac Death: A Prospective Population-Based Cohort Study”
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