129 research outputs found
Determination of methylmercury in environmental matrixes by on-line flow injection and atomic fluorescence spectrometry
No full textImmune responses against SARS-CoV-2 variants after heterologous and homologous ChAdOx1 nCoV-19/BNT162b2 vaccination
No full textAbstract Currently approved viral vector-based and mRNA-based vaccine approaches against coronavirus disease 2019 (COVID-19) consider only homologous prime-boost vaccination. After reports of thromboembolic events, several European governments recommended using AstraZeneca’s ChAdOx1-nCov-19 (ChAd) only in individuals older than 60 years, leaving millions of already ChAd-primed individuals with the decision to receive either a second shot of ChAd or a heterologous boost with mRNA-based vaccines. However, such combinations have not been tested so far. We used Hannover Medical School’s COVID-19 Contact Study cohort of healthcare professionals to monitor ChAd-primed immune responses before and 3 weeks after booster with ChAd ( n = 32) or BioNTech/Pfizer’s BNT162b2 ( n = 55). Although both vaccines boosted prime-induced immunity, BNT162b2 induced significantly higher frequencies of spike-specific CD4 + and CD8 + T cells and, in particular, high titers of neutralizing antibodies against the B.1.1.7, B.1.351 and P.1 variants of concern of severe acute respiratory syndrome coronavirus 2.Abstract Currently approved viral vector-based and mRNA-based vaccine approaches against coronavirus disease 2019 (COVID-19) consider only homologous prime-boost vaccination. After reports of thromboembolic events, several European governments recommended using AstraZeneca’s ChAdOx1-nCov-19 (ChAd) only in individuals older than 60 years, leaving millions of already ChAd-primed individuals with the decision to receive either a second shot of ChAd or a heterologous boost with mRNA-based vaccines. However, such combinations have not been tested so far. We used Hannover Medical School’s COVID-19 Contact Study cohort of healthcare professionals to monitor ChAd-primed immune responses before and 3 weeks after booster with ChAd ( n = 32) or BioNTech/Pfizer’s BNT162b2 ( n = 55). Although both vaccines boosted prime-induced immunity, BNT162b2 induced significantly higher frequencies of spike-specific CD4 + and CD8 + T cells and, in particular, high titers of neutralizing antibodies against the B.1.1.7, B.1.351 and P.1 variants of concern of severe acute respiratory syndrome coronavirus 2
Biogeochemical Cycling of Methylmercury in New York / New Jersey Harbor Estuary
No full textMonomethylmercury (MMHg) is a toxic byproduct of mercury (Hg) pollution in many coastal regions, and is of concern in the anthropogenically impacted (current and past) NY/NJ Harbor estuarine system. The general goal of this research is to investigate the biogeochemical factors affecting the production, distribution, and mobilization of MMHg from sediments in NY/NJ Harbor estuary.Final report to the Hudson River Foundation (HRF). HRF Fellowship: GF/01/04.Purpose: To investigate biogeochemical factors affecting the production, distribution and mobilization of MMHg from sediments in NY/NJ Harbor estuary
Biogeochemical Cycling of Methylmercury in New York / New Jersey Harbor Estuary
No full textMonomethylmercury (MMHg) is a toxic byproduct of mercury (Hg) pollution in many coastal regions, and is of concern in the anthropogenically impacted (current and past) NY/NJ Harbor estuarine system. The general goal of this research is to investigate the biogeochemical factors affecting the production, distribution, and mobilization of MMHg from sediments in NY/NJ Harbor estuary.Final report to the Hudson River Foundation (HRF). HRF Fellowship: GF/01/04.Purpose: To investigate biogeochemical factors affecting the production, distribution and mobilization of MMHg from sediments in NY/NJ Harbor estuary
Author response
No full textThe molecular pathways underlying tumor suppression are incompletely understood. Here, we identify cooperative non-cell-autonomous functions of a single gene that together provide a novel mechanism of tumor suppression in basal keratinocytes of zebrafish embryos. A loss-of-function mutation in atp1b1a, encoding the beta subunit of a Na,K-ATPase pump, causes edema and epidermal malignancy. Strikingly, basal cell carcinogenesis only occurs when Atp1b1a function is compromised in both the overlying periderm (resulting in compromised epithelial polarity and adhesiveness) and in kidney and heart (resulting in hypotonic stress). Blockade of the ensuing PI3K-AKT-mTORC1-NFκB-MMP9 pathway activation in basal cells, as well as systemic isotonicity, prevents malignant transformation. Our results identify hypotonic stress as a (previously unrecognized) contributor to tumor development and establish a novel paradigm of tumor suppression
Investigating Toxicological Effects of Short-Term Resuspension of Metal-Contained Freshwater and Marine Sediments
No full textSediments in navigation-dominated waterways are frequently contaminated with a wide range of chemicals and are subject to resuspension events. There is little information documenting whether adverse ecological effects result from these resuspension of contaminated sediments. I studied the mobilization of metals (Zn, Cu, Cd, Pb, Ni and Cr) during resuspensions of freshwater and marine sediments and whether or not this resulted in toxicity to organisms. Sediment resuspension events were simulated using sediment flux exposure chambers (SeFEC) to resuspend metal-contaminated sediments from Lake DePue (IL) and two Portsmouth (ME) Naval Shipyard sites. Various resuspension events of environmentally relevant suspended particulate matter concentrations (200-1,000 mg/L) were performed. Short-term resuspension events (4 h) resulted in metal- and sediment-specific mobilization. Toxic effects on organisms were limited (Hyalella azteca and Daphnia magna survival, Neanthes arenaceodentata survival, growth and body burden, Pyrocystis lunula bioluminescence) over both the time period of the exposure and during a 4 to 10-d post-recovery period. I conclude that sediment resuspension events at relevant suspended particulate matter concentrations do not release large amounts of dissolved metals, most likely due to the oxidation of reduced iron, manganese and amorphous sulfide species and subsequent readsorption to iron and manganese oxides and organic matter, therefore limiting organisms’ exposure and effects. The redeposition of suspended sediments and associated metal speciation changes, from sulfides to oxides, has the potential to increase metal bioavailability and toxicity to sensitive benthic organisms. While the release of dissolved metals are low, resuspension events still pose the risk of causing toxic responses due to mobilization of contaminated sediments.Master of Science (MS)Natural Resources and EnvironmentUniversity of Michiganhttp://deepblue.lib.umich.edu/bitstream/2027.42/99548/1/KJF_Thesis_draft_080913_FINAL.pd
Echoes and reflections of an author
No full textEcos y refejos de un autor[Claudia Hammerschmidt. “Mi genio es un enano llamadoWalter Ego”. Estrategias de autoría en Guillermo Cabrera Infante.Trad. Beatriz Galán y Claudia Hammerschmidt.Madrid/Frankfurt: Iberoamericana/Vervuert, 2015,412 p.]The title of this recent monograph -translation of "My genius isa dwarf named Walter Ego. " Strategien von Autorschaft beiGuillermo Cabrera Infante (2002) - comes from an interview inthe one that Cabrera Infante talks about his creative idiosyncrasy with Isabel Álvarez-Borland. The author converts the words thatSilvestre, writer-narrator of Tres tristes tigres , pronouncesbe reflected in a mirror - "Is it me who looks at me throughof the mirror? Or is it my alter ego? Walter Ego "( Three sad tigers,Barcelona, Seix Barral, 1991, 349) - in a personal definitionwhen he states categorically: "My genius is a dwarf called Walter Ego "(Álvarez-Borland, Hispamérica: Revista deLiterature 31, 1982, 54).<br/
Echoes and reflections of an author
No full textEcos y refejos de un autor[Claudia Hammerschmidt. “Mi genio es un enano llamadoWalter Ego”. Estrategias de autoría en Guillermo Cabrera Infante.Trad. Beatriz Galán y Claudia Hammerschmidt.Madrid/Frankfurt: Iberoamericana/Vervuert, 2015,412 p.]The title of this recent monograph -translation of "My genius isa dwarf named Walter Ego. " Strategien von Autorschaft beiGuillermo Cabrera Infante (2002) - comes from an interview inthe one that Cabrera Infante talks about his creative idiosyncrasy with Isabel Álvarez-Borland. The author converts the words thatSilvestre, writer-narrator of Tres tristes tigres , pronouncesbe reflected in a mirror - "Is it me who looks at me throughof the mirror? Or is it my alter ego? Walter Ego "( Three sad tigers,Barcelona, Seix Barral, 1991, 349) - in a personal definitionwhen he states categorically: "My genius is a dwarf called Walter Ego "(Álvarez-Borland, Hispamérica: Revista deLiterature 31, 1982, 54).<br/
Concentrations of dissolved and particulate mercury species collected on the US GEOTRACES Arctic cruise (HLY1502, GN01) from August to October 2015
No full textDataset: GN01 Dissolved and Particulate MercuryConcentrations of dissolved and particulate mercury species, including elemental, total, monomethyl- and dimethylmercury, collected on GN01 (HLY1502) from August to October 2015 as part of the U.S. GEOTRACES Arctic project.
For a complete list of measurements, refer to the full dataset description in the supplemental file 'Dataset_description.pdf'. The most current version of this dataset is available at: https://www.bco-dmo.org/dataset/827530NSF Division of Ocean Sciences (NSF OCE) OCE-1434653, NSF Division of Ocean Sciences (NSF OCE) OCE-153431
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