2,089,330 research outputs found

    TACC3-ch-TOG track the growing tips of microtubules independently of clathrin and Aurora-A phosphorylation

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    The interaction between TACC3 (transforming acidic coiled coil protein 3) and the microtubule polymerase ch-TOG (colonic, hepatic tumor overexpressed gene) is evolutionarily conserved. Loading of TACC3–ch-TOG onto spindle microtubules requires the phosphorylation of TACC3 by Aurora-A kinase and the subsequent interaction of TACC3 with clathrin to form a microtubule binding surface. Whether there is a pool of TACC3–ch-TOG that is independent of clathrin in human cells, and what is the function of this pool, are open questions. Here, we report that TACC3 is recruited to the plus-ends of microtubules by its association with ch-TOG and that this pool is independent of phosphorylation and binding to clathrin. The plus-end binding of TACC3–ch-TOG persists in interphase and we propose that one cellular function of TACC3–ch-TOG is to modulate cell migration. We also describe the distinct subcellular pools of TACC3, ch-TOG and clathrin. TACC3 is often described as a centrosomal protein, but we show that there is no significant population of TACC3 at centrosomes. The delineation of distinct protein pools reveals a simplified view of how these proteins are organized and controlled by post-translational modification

    [Stammbuch Ch. D.] / Ch. D.

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    [STAMMBUCH CH. D.] / CH. D. [Stammbuch Ch. D.] / Ch. D. (1) Cover (1) Chapter (7) Einträge Bl. 1 - 20 (8) Einträge Bl. 21 - 40 (19) Einträge Bl. 41 - 79 (31) Einlage: Scherenschnitt (42

    Couleurs de Ch. Lorilleux & cie : spécimen typographique.

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    Catalogue des encres de couleur pour typographie de la maison Ch. Lorilleux.Comprend : Liste des prix-courant (2 p.) ; le logo de la marque de fabrique (1 p.) ; un modèle d'affiche "Encre d'imprimerie. Couleurs vernis. Ch. Lorilleux & cie, 16 rue Suger, Paris. 50 succursales & dépôts" et un modèle d'illustration avec une reproduction de la sculpture du Moïse de Michel-Ange, imprimés en différentes couleurs.La page de titre porte les mentions "Expositions universelles de Paris 1889 & 1900. Membre du jury - hors concours. Saint-Louis 1904 - Grand-prix.

    ch-sa/labelCloud: v0.6.9

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    First release with refined pip package structure. Installation via pip from PyPi is now possible. What's Changed Fix save perspective by @ch-sa in https://github.com/ch-sa/labelCloud/pull/33 Add modules to improve structure by @ch-sa in https://github.com/ch-sa/labelCloud/pull/38 Limit initial zoom to far_plane by @ch-sa in https://github.com/ch-sa/labelCloud/pull/40 Add necessary transformation to KITTI by @ch-sa in https://github.com/ch-sa/labelCloud/pull/43 Add 2D image viewer by @ChoHyoungSeo in https://github.com/ch-sa/labelCloud/pull/44 Prepare project for pip packaging by @ch-sa in https://github.com/ch-sa/labelCloud/pull/45 Update setup and docs by @ch-sa in https://github.com/ch-sa/labelCloud/pull/46 Fix paths in ui and settings by @ch-sa in https://github.com/ch-sa/labelCloud/pull/48 Optimize for pip packaging by @ch-sa in https://github.com/ch-sa/labelCloud/pull/49 Pip Refactoring by @ch-sa in https://github.com/ch-sa/labelCloud/pull/50 Fix package_data by @ch-sa in https://github.com/ch-sa/labelCloud/pull/51 New Contributors @ChoHyoungSeo made their first contribution in https://github.com/ch-sa/labelCloud/pull/44 Full Changelog: https://github.com/ch-sa/labelCloud/compare/v0.6.0...v0.6.

    ch-sa/labelCloud: v0.6.7

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    First release with refined pip package structure. Installation via pip from PyPi is now possible. What's Changed Fix save perspective by @ch-sa in https://github.com/ch-sa/labelCloud/pull/33 Add modules to improve structure by @ch-sa in https://github.com/ch-sa/labelCloud/pull/38 Limit initial zoom to far_plane by @ch-sa in https://github.com/ch-sa/labelCloud/pull/40 Add necessary transformation to KITTI by @ch-sa in https://github.com/ch-sa/labelCloud/pull/43 Add 2D image viewer by @ChoHyoungSeo in https://github.com/ch-sa/labelCloud/pull/44 Prepare project for pip packaging by @ch-sa in https://github.com/ch-sa/labelCloud/pull/45 Update setup and docs by @ch-sa in https://github.com/ch-sa/labelCloud/pull/46 Fix paths in ui and settings by @ch-sa in https://github.com/ch-sa/labelCloud/pull/48 Optimize for pip packaging by @ch-sa in https://github.com/ch-sa/labelCloud/pull/49 Pip Refactoring by @ch-sa in https://github.com/ch-sa/labelCloud/pull/50 New Contributors @ChoHyoungSeo made their first contribution in https://github.com/ch-sa/labelCloud/pull/44 Full Changelog: https://github.com/ch-sa/labelCloud/compare/v0.6.0...v0.6.

    ch-sa/labelCloud: v0.7.7

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    What's Changed Added navigation to custom pointcloud index by @francescofact in https://github.com/ch-sa/labelCloud/pull/71 Fix integration tests by @ch-sa in https://github.com/ch-sa/labelCloud/pull/72 Fix 2D image view by @ch-sa in https://github.com/ch-sa/labelCloud/pull/79 New Contributors @francescofact made their first contribution in https://github.com/ch-sa/labelCloud/pull/71 Full Changelog: https://github.com/ch-sa/labelCloud/compare/v0.7.6...v0.7.

    ch-sa/labelCloud: v0.7.3

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    What's Changed Set label_folder as Path by @ch-sa in https://github.com/ch-sa/labelCloud/pull/58 Full Changelog: https://github.com/ch-sa/labelCloud/compare/v0.7.2...v0.7.

    ch-sa/labelCloud: v0.7.2

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    What's Changed Fix icon point cloud path by @ch-sa in https://github.com/ch-sa/labelCloud/pull/56 Full Changelog: https://github.com/ch-sa/labelCloud/compare/v0.7.1...v0.7.
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