199 research outputs found
Milstein: Houssay y los procesos formativos en ciencia
No full textCésar Milstein se refiere a la influencia que recibió de Stoppani y los premios nobel que lo precedieron: Houssay y Leloir, a la importancia de los procesos formativos en ciencia, de cómo se aprende la ciencia, la administración de la ciencia y la excelencia académica.
Este es un segmento de una entrevista realizada al Dr. Cesar Milstein con motivo de su reconocimiento con el Premio Konex de Brillante 1993 en Ciencia y Tecnología. Agradecemos la gentileza de la Fundación konex.copiaFil: No especifica. No especifíca;ColorRealización audiovisual Fundación Konex; Gráfica para este segmento: Sol DiesslervideoVideosUnidad documental simpl
Differential profile of ultrasound findings associated with malignancy in mixed and solid thyroid nodules in an elderly female population
No full textObjective. Ultrasonographic characteristics are associated with thyroid malignancy. Our aim was to compare the diagnostic value of ultrasound features in the detection of thyroid malignancy in both solid and mixed nodules. Methods. We prospectively studied female patients (≥50 years) referred to ultrasound-guided fine needle aspiration biopsy. Ultrasound features considered suspicious were hypoechogenicity, microcalcifications, irregular margins, high anteroposterior (AP)/axial-ratio, and absent halo. Associations were separately assessed in mixed and solid nodules. Results. In a group of 504 elderly female patients (age = years), the frequency of malignant cytology was 6%. Thirty-one percent of nodules were mixed and 60% were solid. The rate of malignant cytology was similar for mixed and solid nodules (7.4 versus 5.8%, : 0.56). While in mixed nodules none of the ultrasound characteristics were associated with malignant cytology, in solid nodules irregular margins and microcalcifications were significant (all ). The combination of irregular margins and/or microcalcifications significantly increased the association with malignant cytology only in solid nodules (OR: 2.76 (95% CI: 1.25–6.10), : 0.012). Conclusions. Ultrasound features were of poor diagnostic value in mixed nodules, which harbored malignant lesions as often as solid nodules. Our findings challenge the recommended minimal size for ultrasound-guided fine needle aspiration biopsy in mixed nodules.Fil: Vera, María Inés. Dr. Cesar Milstein Hospital; ArgentinaFil: Meroño, Tomás. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Urrutia, María Agustina. Dr. Cesar Milstein Hospital; ArgentinaFil: Parisi, Carina. Dr. Cesar Milstein Hospital; ArgentinaFil: Morosan, Yanina. Dr. Cesar Milstein Hospital; ArgentinaFil: Rosmarin, Melanie. Dr. Cesar Milstein Hospital; ArgentinaFil: Schnitman, Marta. Dr. Cesar Milstein Hospital; ArgentinaFil: Brites, Fernando Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Grisendi, Silvio. Dr. Cesar Milstein Hospital; ArgentinaFil: Serrano, María Sol. Dr. Cesar Milstein Hospital; ArgentinaFil: Luciani, Wilfredo. Dr. Cesar Milstein Hospital; ArgentinaFil: Serrano, Leonardo. Dr. Cesar Milstein Hospital; ArgentinaFil: Zuk, Carlos. Dr. Cesar Milstein Hospital; ArgentinaFil: de Barrio, Guillermo. Dr. Cesar Milstein Hospital; ArgentinaFil: Cejas, Claudia. Dr. Cesar Milstein Hospital; ArgentinaFil: Faingold, María Cristina. Dr. Cesar Milstein Hospital; ArgentinaFil: Brenta, Gabriela. Dr. Cesar Milstein Hospital; Argentin
Las investigaciones de César Milstein: cuestiones sobre la microsociologia de la investigación científica
No full textFil: Peyrú, Graciela. Universidad Nacional de Tres de Febrero; Argentina.En este texto, haré una revisión sistemática de las transformaciones verificadas en la prolífica
producción científica de Cesar Milstein a lo largo de su carrera, explorando las posibles
correlaciones entre distintos cambios significativos, tanto en la temática que va desarrollando,
como en los alcances y la complejidad de sus investigaciones, para analizar la posible
repercusión de aquellos factores socioeconómicos, geográficos y políticos que las acompañan. Se
revisará de este modo la aplicabilidad del análisis microsociológico realizado por Mario Biagioli
en dos de sus textos básicos sobre Galileo, a los distintos cambios verificados en la producción
de otro científico relevante ..Fil: Peyrú, Graciela. Universidad Nacional de Tres de Febrero; Argentina
An efficient tamed Milstein Scheme for the Stochastic Allen-Cahn equation with multiplicative noise
No full text©The Author(s) 2026.The version of record of this article, first published in [Journal of Scientific Computing], is available online at Publisher’s website: http://dx.doi.org/10.1007/s10915-026-03218-7This paper investigates the strong convergence of a fully discrete scheme for the stochastic Allen–Cahn equation with multiplicative noise, combining a tamed Milstein method for the temporal discretization with the finite element method in space. The proposed method is shown to be unconditionally stable in spatial dimensions d ∈{1,2,3}. Beyond the inherent challenges caused by, see, e.g., [1], the cubic non-globally Lipschitz drift term and multiplicative driving noise in the convergence analysis, the Milstein scheme further complicates the error estimation of the noise term compared to the Euler-Maruyama discretization. By introducing a novel auxiliary process, we rigorously establish strong convergence rates in both space and time under mild assumptions for d ∈{1,2}. Our analysis shows that the temporal convergence order is doubled compared to that of tamed Euler-Maruyama scheme. Numerical experiments are provided to confirm the theoretical results and to demonstrate that the proposed scheme exhibits improved robustness over the pure semi-implicit Milstein method
Resurgence of canine parvovirus 2a strain in the domestic dog population from Argentina
No full textNinety-three rectal swab samples were taken, from dogs suspected of canine parvovirus (CPV) infectionand analyzed by PCR. A fragment of the VP2 gene, was amplified in 41 (44%) of them, resulting CPVpositive samples. Sequencing analysis of these PCR products showed that 37 samples (90.2%) belongedto the CPV2c type, whereas four samples (9.8%) were identified as CPV2a, which has not been found since2008.It was also found that 24 out of 37 CPV2c samples (65%), carried the mutation Thr440Ala, whereas thismutation was absent in the four CPV2a strains reported herein.Using phylogenetic analysis of the full length VP2 gene, which was amplified by PCR in six local samples,it was seen that CPV2a Argentine strains reported in this study, were genetically closer to a previouslocal CPV2a isolate (year 2003) and to a South African CPV2a strain, than to any of the recently reportedUruguayan CPV2a strains.The results obtained in this work, together with those reported previously in Uruguay strongly suggestthat, in spite of the geographical proximity, wild type CPV strains undergo different evolutive pathwaysin each country, resulting in the prevalence of different strains in related dog populations.Further extensive epidemiological studies are needed in order to improve the understanding of CPVevolution.Fil: Gallo Calderon, Marina Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencias y Tecnología "Dr. Cesar Milstein"; ArgentinaFil: Romanutti, Carina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencias y Tecnología "Dr. Cesar Milstein"; ArgentinaFil: Wilda, Maximiliano. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencias y Tecnología "Dr. Cesar Milstein"; ArgentinaFil: D'antuono, Alejandra Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencias y Tecnología "Dr. Cesar Milstein"; ArgentinaFil: Keller, Leticia. Fundación de Estudios en Virología Animal; ArgentinaFil: Giacomodonato, Mónica Nancy. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica; ArgentinaFil: Mattion, Nora Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencias y Tecnología "Dr. Cesar Milstein"; ArgentinaFil: la Torre, Jose Leonardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencias y Tecnología "Dr. Cesar Milstein"; Argentin
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