88,973 research outputs found
Opposite Roles of NMDA Receptors in Relapsing and Primary Progressive Multiple Sclerosis
No full textRossi S, Studer V, Moscatelli A, Centonze D. Opposite Roles of NMDA Receptors in Relapsing and Primary Progressive Multiple Sclerosis. PLoS ONE. 2013;8(6): e67357
Prevalence and management of panic attacks during infliximab infusion in psoriatic patients
No full textBACKGROUND:
Psoriasis is a chronic, inflammatory skin disease associated with anxiety and depression. Infliximab (IFX) is a human/mouse chimeric anti-TNF-α antibody effective in the treatment of psoriasis.
OBJECTIVE:
The aim of this study was to evaluate the prevalence of panic disorders in psoriatic patients during IFX infusions.
METHODS:
A retrospective study was performed on patients affected with psoriasis who were treated with IFX from 2002 to 2011 at a single center. Panic disorders were defined using the clinical criteria of the Diagnostic and Statistical Manual of Mental Disorders, 4th edition. A population of dermatological patients under treatment with IVG, rituximab, apheresis, intravenous corticosteroids and antibiotics was considered as the control group.
RESULTS:
A total of 141 patients were evaluated. Of these, 6 (4.25%) experienced panic attacks during the infusion; 16 (11.3%) had a medical history of panic attack and of those 5/16 (31%) experienced panic attacks during IFX infusion. In the control group panic attacks were not recorded.
CONCLUSION:
We describe 6 cases of patients in whom panic attacks were triggered by IFX infusion. Premedication with oral benzodiazepine and a slow rate of infusion is recommended
Peripheral and total parenteral nutritions as strongest risk factors for nosocomial candidemia among elderly patients: a case-control study
No full texteP803
Abstract (eposter session)
Peripheral and total parenteral nutritions as the strongest risk factors for nosocomial candidaemia
among elderly patients: a case-control study
R. Luzzati*, S. Cavinato, G. Granà, M. Giangreco, M. Deiana, S. Centonze, F. Barbone (Trieste, Verona, Udine,
IT)
Objectives: Although the highest rates of nosocomial candidemia occur at the extremes of age spectrum, few
data on elderly patients exist. We investigate characteristics and risk factors for candidemia in such patient
population. Methods: We analyzed all consecutive nosocomial candidemia episodes occurring from January
2008 to June 2011 in an Italian referral hospital. A case-control study to identify risk factors for candidemia
including comorbidities, invasive procedures, and medical therapies was performed. For each case, 2 controls
were randomly selected among other patients admitted to the same hospital, and individually matched by sex,
age, year and month of admission, ward, and duration of hospital admission. The statistical analysis was
conducted according to matched case-control methods. The adjusted odds ratio (OR) was calculated using
multiple conditional logistic regression. Results: We identified 145 episodes of candidemia occurring in 140
patients (67 females, 48%) with a median age of 80 years (IQR 69.0-85.5 years ). The overall incidence of
candidemia was 1.56 episodes per 10,000 patient-days per year. Ninety-three (67%) patients were hospitalized
in internal medicine units, 23 (16%) in surgery units, and 24 (17%) in intensive care units. Candida albicans (80
isolates) accounted for 55% of all candidemia episodes. From the multivariate logistic regression models which
also included terms for matching variables, candidemia remained statistically significantly associated with
duration > 7 days of both total [OR = 23.40; 95% confidence interval (CI): 3.81-143.59]and peripheral
parenteral nutrition [OR = 24.82; 95%CI: 6.23-98.82], central vascular catheter [OR = 5.61; 95%CI: 1.32-
23.82], and the following antibiotics for >= 2 days: glicopeptydes [OR = 6.23; 95%CI: 1.88-20.67],
aminoglycosides [OR = 2.75; 95%CI: 0.62-12.19], metronidazole [OR = 2.71; 95%CI: 0.80-9.17], and
antianaerobic betalactams [OR = 2.44; 95%CI: 1.00-5.94]. The 30-day crude mortality was 45.0% in
candidemia cases and 20.7% in controls. Conclusion: Our data show the incidence of candidemia to be high and
elderly patients admitted into internal medicine wards to be especially affected by that infection. The longer
durations of both total and peripheral parenteral nutritions were found to be the strongest risk factors for
candidemia. Prospective studies are warranted to show whether candidemia can be prevented by earlier
application of enteral feeding in elderly patients
Search for heavy Majorana or Dirac neutrinos and right-handed W gauge bosons in final states with charged leptons and jets in pp collisions at sqrt(s) = 13 TeV with the ATLAS detector
No full textA search for heavy right-handed Majorana or Dirac neutrinos NR and heavy right-handed gauge bosons WR is performed in events with energetic electrons or muons, with the same or opposite electric charge, and energetic jets. The search is carried out separately for topologies of clearly separated final-state products (“resolved” channel) and topologies with boosted final states with hadronic and/or leptonic products partially overlapping and reconstructed as a large-radius jet (“boosted” channel). The events are selected from pp collision data at the LHC with an integrated luminosity of 139 fb-1 collected by the ATLAS detector at sqrt(s) = 13 TeV. No significant deviations from the Standard Model predictions are observed. The results are interpreted within the theoretical framework of a left-right symmetric model, and lower limits are set on masses in the heavy right-handed WR boson and NR plane. The excluded region extends to about M(WR) = 6.4 TeV for both Majorana and Dirac NR neutrinos at M(WR) < 1 TeV. NR with masses of less than 3.5 (3.6) TeV are excluded in the electron (muon) channel at M(WR) = 4.8 TeV for the Majorana neutrinos, and limits of m(NR) up to 3.6 TeV for m(WR) = 5.2 (5.0) TeV in the electron (muon) channel are set for the Dirac neutrinos. These constitute the most stringent exclusion limits to date for the model considered
Search for direct pair production of sleptons and charginos decaying to two leptons and neutralinos with mass splittings near the W-boson mass in sqrt(s) = 13 TeV pp collisions with the ATLAS detector
No full textA search for the electroweak production of pairs of charged sleptons or charginos decaying into two-lepton final states with missing transverse momentum is presented. Two simplified models of R-parity-conserving supersymmetry are considered: direct pairproduction of sleptons ( ̃l` ̃l`), with each decaying into a charged lepton and a ̃ 01 neutralino, and direct pair-production of the lightest charginos ( ̃ ±1 ̃ 1 ), with each decaying into a Wboson and a ̃ 01. The lightest neutralino ( ̃ 01) is assumed to be the lightest supersymmetric particle (LSP). The analyses target the experimentally challenging mass regions where m( ̃`)−m( ̃ 01) and m( ̃ ±1 )−m( ̃ 01) are close to the W-boson mass (‘moderately compressed’ regions). The search uses 139 fb−1 of p sqrt(s) = 13TeV proton-proton collisions recorded by the ATLAS detector at the Large Hadron Collider. No significant excesses over the expected background are observed. Exclusion limits on the simplified models under study are reported in the ( ̃`, ̃ 01) and ( ̃ ±1 , ̃ 01) mass planes at 95% confidence level (CL). Sleptons with masses up to 150 GeV are excluded at 95% CL for the case of a mass-splitting between sleptons and the LSP of 50 GeV. Chargino masses up to 140 GeV are excluded at 95% CL for the case of a mass-splitting between the chargino and the LSP down to about 100 GeV
Search for long-lived, massive particles in events with displaced vertices and multiple jets in pp collisions at sqrt(s) = 13 TeV with the ATLAS detector
No full textA search for long-lived particles decaying into hadrons is presented. The analysis uses 139 fb−1 of pp collision data collected at sqrt(s) = 13 TeV by the ATLAS detector at the LHC using events that contain multiple energetic jets and a displaced vertex. The search employs dedicated reconstruction techniques that significantly increase the sensitivity to long-lived particles decaying in the ATLAS inner detector. Background estimates for Standard Model processes and instrumental effects are extracted from data. The observed event yields are compatible with those expected from background processes. The results are used to set limits at 95% confidence level on model-independent cross sections for processes beyond the Standard Model, and on scenarios with pair-production of supersymmetric particles with long-lived electroweakinos that decay via a small R-parity-violating coupling. The pair-production of electroweakinos with masses below 1.5 TeV is excluded for mean proper lifetimes in the range from 0.03 ns to 1 ns. When produced in the decay of m(g∼) = 2.4 TeV gluinos, electroweakinos with m(χ∼01) = 1.5 TeV are excluded with lifetimes in the range of 0.02 ns to 4 ns
Search for neutral long-lived particles that decay into displaced jets in the ATLAS calorimeter in association with leptons or jets using pp collisions at sqrt(s) = 13 TeV
No full textA search for neutral long-lived particles (LLPs) decaying in the ATLAS hadronic calorimeter using 140 fb of proton-proton collisions at sqrt(s) = 13 TeV delivered by the LHC is presented. The analysis is composed of three channels. The first targets pair-produced LLPs, where at least one LLP is produced with sufficiently low boost that its decay products can be resolved as separate jets. The second and third channels target LLPs respectively produced in association with a or boson that decays leptonically. In each channel, different search regions target different kinematic regimes, to cover a broad range of LLP mass hypotheses and models. No excesses of events relative to the background predictions are observed. Higgs boson branching fractions to pairs of hadronically decaying neutral LLPs larger than 1% are excluded at 95% confidence level for proper decay lengths in the range of 30 cm to 4.5 m depending on the LLP mass, a factor of three improvement on previous searches in the hadronic calorimeter. The production of long-lived dark photons in association with a Z boson with cross-sections above 0.1 pb is excluded for dark photon mean proper decay lengths in the range of 20 cm to 50 m, improving previous ATLAS results by an order of magnitude. Finally, long-lived photo-phobic axion-like particle models are probed for the first time by ATLAS, with production cross-sections above 0.1 pb excluded in the 0.1 mm to 10 m range
Measurement of single top-quark production in the s-channel in proton–proton collisions at sqrt(s) = 13 TeV with the ATLAS detector
No full textA measurement of single top-quark production in the s-channel is performed in proton–proton collisions at a centre-of-mass energy of 13 TeV with the ATLAS detector at the CERN Large Hadron Collider. The dataset corresponds to an integrated luminosity of 139 fb−1. The analysis is performed on events with an electron or muon, missing transverse momentum and exactly two b-tagged jets in the final state. A discriminant based on matrix element calculations is used to separate single-top-quark s-channel events from the main background contributions, which are top-quark pair production and W-boson production in association with jets. The observed (expected) signal significance over the background-only hypothesis is 3.3 (3.9) standard deviations, and the measured cross-section is σ=8.2+3.5−2.9 pb, consistent with the Standard Model prediction of σSM=10.32+0.40−0.36 pb
Constraints on simplified dark matter models involving an s-channel mediator with the ATLAS detector in pp collisions at sqrt(s) = 13 TeV
No full textThis paper reports a summary of searches for a fermionic dark matter candidate in the context of theoretical models characterised by a mediator particle exchange in the s-channel. The data sample considered consists of pp collisions delivered by the Large Hadron Collider during its Run 2 at a centre-of-mass energy of sqrt(s) = 13 TeV and recorded by the ATLAS detector, corresponding to up to 140 fb^-1. The interpretations of the results are based on simplified models where the new mediator particles can be spin-0, with scalar or pseudo-scalar couplings to fermions, or spin-1, with vector or axial-vector couplings to fermions. Exclusion limits are obtained from various searches characterised by final states with resonant production of Standard Model particles, or production of Standard Model particles in association with large missing transverse momentum
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