1,721,165 research outputs found
Valle d’Aosta militare. Esercito, cultura e società in una regione di frontiera 1848-1940
Full text linkDopo un’introduzione dedicata alla figura del combattente valdostano nella letteratura e nel fumetto italiani, la tesi descrive, nella prima parte, le ragioni e le modalità della presenza militare in Valle d’Aosta, tra il 1848 e il 1940, e, nella seconda, le conseguenze di tale presenza sulla popolazione, a livello sociale, politico e culturale. Nelle conclusioni, si presentano le possibili spiegazioni del silenzio che ha interessato, dopo il 1945, la tradizione militare valdostan
PADGEM: an adhesion receptor for leukocytes on stimulated platelets and endothelial cells
No full text
Cancer associated venous thromboembolism
Full text linkCancer represents a well recognized risk factor for venous thromboembolism. Patients with cancer have a 4–7 fold higher risk for venous thromboembolism than patients without the disease. Some sites of cancer (e.g. pancreas, stomach) are associated with a higher risk than others (e.g. breast, prostate); advanced stage is also associated with a higher risk. Finally, numerous chemotherapeutic agents contribute to the development of venous thromboembolism. Despite the high incidence of thromboembolism, routine primary prophylaxis is not recommended in most cancer patients. Scores that evaluate site, stage and concomitant risk factors are being evaluated but have not gained widespread acceptance to date. Screening patients with venous thromboembolism for occult cancers has shown little impact on survival and in general is not recommended. The pathogenesis of thrombosis in cancer patients, although extremely complex, involves the synthesis of proinflammatory mediators by the host that contributes to the activation of the coagulation cascade, as well as the synthesis of the procoagulant and proangiogenic factor, tissue factor, by the tumor. Patients with venous thromboembolism and active cancer are usually treated with low molecular weight heparin for 6 months; after that, there are no clear guidelines to suggest the best therapeutic approach. The new direct oral anticoagulants are currently not indicated in these patients; however, clinical studies are in progress to evaluate their promising role in this setting.
Keywords: cancer, venous thromboembolism, vitamin K antagonists, low molecular weight heparin, direct oral anticoagulants, tissue facto
Aliskiren, a renin inhibitor, downregulates TNF-{alpha}-induced tissue factor expression in HUVECS
No full textMicroparticles and a P-selectin-mediated pathway of blood coagulation
No full textNo abstract available (review)
The paper describes a new paradigm for blood coagulation. According to this new interpretation, microparticle-bound, circulating tissue factor is concentrated to the site of endothelial activation through the interaction of P-selectin with its cognate ligand, PSGL.1
Pulmonary embolism: yet another cause of hypoxaemic respiratory failure in COVID-19
Full text linkPulmonary embolism represents an overlooked cause of worsening respiratory failure in COVID-19. A regular bedside evaluation for atypical features like pleuritic chest pain or pleural effusion could help identify suspected cases for appropriate management
Collecting symptoms and signs of pulmonary embolism: advantage of standardized questionnaire in respect to conventional interview
No full textBull. Europ. Physiopath. Res
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