180,562 research outputs found
Domenico e Pellegrino Tibaldi. Architettura e Arte a Bologna nel Secondo Cinquecento
No full textIdeazione e responsabilirà scientifica del primo convegno internazionale di studi sulla architettura del tardo Cinquecento a Bologna. F. Ceccarelli e D. Lenzi sono i curatori degli Atti del Convegn
L. Isebaert, R. Lebrun (éds), Quaestiones Homericae. Acta Colloquii Namurcensis habiti diebus 7-9 mensis Septembris anni 1995
No full textCeccarelli Paola. L. Isebaert, R. Lebrun (éds), Quaestiones Homericae. Acta Colloquii Namurcensis habiti diebus 7-9 mensis Septembris anni 1995. In: Gaia : revue interdisciplinaire sur la Grèce Archaïque, numéro 5, 2001. pp. 205-208
Heme Proteins: The Role of Solvent on the Dynamics of Gates and Portals Revealed by MD Simulations
No full textIn the family of respiratory proteins, hemoglobins and myoglobins have been the first to be crystallized in ‘50. Despite the availability of 3D structures, issues regarding the microscopic functioning remain open, such as, for instance, the R to T switching mechanism in hemoglobin or the ligand escape process in myoglobin. Due to the relatively small number of residues, myoglobin is the suitable candidate to investigate the more general structure-function paradigm, being defined as the hydrogen atom of biology. In this work, to complement our recent study on the dynamics of internal cavities of myoglobin[1], the effect of solvation on these intrinsic pathways has been explored. In particular, 60ns-long molecular dynamics simulation of horse heart met-myoglobin was further analyzed and the dynamics of waters residing around/inside the protein with average residence times of up to tens of nanoseconds was monitored. Together with the knowledge obtained previously[1], the analysis of solvent revealed that myoglobin has in fact only few stable hydration sites in which a water molecule can stay for time longer than 2 ns. Strikingly, all of these sites are close to protein/solvent portals observed in previous studies focused on the entry/escape and migration of various ligands in myoglobin[2-4].
1. Scorciapino, M. A.; Robertazzi, A.; Casu, M.; Ruggerone, P.; Ceccarelli, M. J. Am. Chem. Soc. 2009, 131, 11825-11832.
2. Cohen, J.; Arkhipov, A.; Braun, R.; Schulten, K. Biophys. J. 2006, 91, 1844-1857.
3. Ruscio, J. Z.; Kumar, D.; Shukla, M.; Prisant, M. G.; Murali, T. M.; Onufriev, A. V. Proc. Natl. Acad. Sci. USA 2008, 105, 9204-9209.
4. Ceccarelli, M.; Anedda, R.; Casu, M.; Ruggerone, P. Proteins 2008, 71, 1231-1236
Re-thinking diabetic nephropathy: Microalbuminuria is just a piece of the diagnostic puzzle
No full textThe decline of the estimated glomerular filtration rate (eGFR) and the presence of albuminuria are the typical hallmarks of kidney disease arising as one of the most frequent diabetic complications over a long period of time, generally known as diabetic nephropathy or diabetes kidney disease (DKD). However, a decline in the renal function may occur in diabetic patients for other reasons unrelated to glycemic control, and this condition is known as non-diabetic kidney disease (NDKD). In this opinion paper we will review these conditions, and we outline the importance of other investigations, such as kidney biopsy and the measurement of novel biomarkers, in order to identify the disease progression early, and to allow a timely intervention. We will also focus on the actual limits of the quantitative measurements of albumin in urine, especially with regards to potential interferences due to the treatment of patients with statins
FROM BIODIVERSITY SAFEGUARD TO WOOD FIRE PREVENTION: THE ANATOMY APPLIED TO THE ANIMAL WELL BEING
No full textAnatomical researches, supporting eco-vegetational investigation focussed on the pastural ecosystem biodiversity maintainance, allowed the validation of BCS as representative parameter of morphofunctional modifications which are strictly related to ecological-productive variations of the grassland systems (Ceccarelli, It J Anat Embryol 114, 2009). A cause of wood fire primer is the presence of necromass in the wood/pasture fringes characterized by a strong covering of Brachypodium rupestre (Br. r.), a tall grass lowly palatable for ovine because of its silicate rich and high fibrousness leaves. However, sheep closed in fences on Br. r. highly covered zone, exploit all forage resources, preventing the fire primer. So, a sheep experimental group was taken to graze for twenty days on Br. r. highly covered plot; during this period, the ruminal mucosa keratinization degree and the body state modifications (BCS and body weight) were monitored in order to determine the animal stay length without negatively affect their well being. Data were then compared with those of sheep control group grazing on a natural semi-mesophylic pasture. Experimental group showed a body weight mean decrease of 1,79 kg and a marked BCS decrement (-1,10). In control group BCS slightly decreased (-0,13) and body weight increased of 0,62 kg. Keratinization degree changed more in experimental group (17,2%-31,7% in rumen atrium, 20%-37,3% in rumen ventral sac) than in control one (17%-19,5% in rumen atrium, 20,2%-22,1% in rumen ventral sac). Considering that the high keratinization degree was quickly reached, while the most negative effects on BCS and body weight occurred after twenty days of grazing on Br. r. pasture, it seems advisable for animals to stay on this pasture not more than 10-15 days
Toward a New Historiography
No full textThe history of evolutionary biology presents well-established categorizations and
labels that have significantly influenced the imaginary of evolutionism. The
somewhat uncritical understanding and use of such labels demand a thorough
reconsideration of traditional narratives, thus paving the way for new research
avenues to emerge
From biodiversity safeguard to wood fire prevention: the anatomy applied to the animal well being
No full textAnatomical researches, supporting eco-vegetational investigation focussed on the
pastural ecosystem biodiversity maintainance, allowed the validation of BCS as representative
parameter of morphofunctional modifications which are strictly related to
ecological-productive variations of the grassland systems (Ceccarelli, It J Anat Embryol
114, 2009). A cause of wood fire primer is the presence of necromass in the wood/
pasture fringes characterized by a strong covering of Brachypodium rupestre (Br. r.), a
tall grass lowly palatable for ovine because of its silicate rich and high fibrousness
leaves. However, sheep closed in fences on Br. r. highly covered zone, exploit all forage
resources, preventing the fire primer. So, a sheep experimental group was taken
to graze for twenty days on Br. r. highly covered plot; during this period, the ruminal
mucosa keratinization degree and the body state modifications (BCS and body
weight) were monitored in order to determine the animal stay length without negatively
affect their well being. Data were then compared with those of sheep control
group grazing on a natural semi-mesophylic pasture. Experimental group showed
a body weight mean decrease of 1,79 kg and a marked BCS decrement (-1,10). In
control group BCS slightly decreased (-0,13) and body weight increased of 0,62 kg.
Keratinization degree changed more in experimental group (17,2%-31,7% in rumen
atrium, 20%-37,3% in rumen ventral sac) than in control one (17%-19,5% in rumen
atrium, 20,2%-22,1% in rumen ventral sac). Considering that the high keratinization
degree was quickly reached, while the most negative effects on BCS and body weight
occurred after twenty days of grazing on Br. r. pasture, it seems advisable for animals
to stay on this pasture not more than 10-15 days
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