102,787 research outputs found
Artificial intelligence in dermatopathology: Updates, strengths, and challenges
No full textArtificial intelligence (AI) has evolved to become a significant force in various domains, including medicine. We explore the role of AI in pathology, with a specific focus on dermatopathology and neoplastic dermatopathology. AI, encompassing machine learning and deep learning, has demonstrated its potential in tasks ranging from diagnostic applications on whole slide imaging to predictive and prognostic functions in skin pathology. In dermatopathology, studies have assessed AI's ability to identify skin lesions, classify melanomas, and improve diagnostic accuracy. Results indicate that AI, particularly convolutional neural networks, can outperform human pathologists in terms of sensitivity and specificity. AI aids in predicting disease outcomes, identifying aggressive tumors, and differentiating between various skin conditions. Neoplastic dermatopathology showcases AI's prowess in classifying melanocytic lesions, discriminating between melanomas and nevi, and aids dermatopathologists in making accurate diagnoses. Studies emphasize the reproducibility and diagnostic aid that AI provides, especially in challenging cases. In inflammatory and lymphoproliferative dermatopathology, limited research exists, but studies show attempts to use AI to differentiate conditions such as mycosis fungoides and eczema. Although some results are promising, further exploration is needed in these areas. We highlight the extraordinary interest AI has garnered in the scientific community and its potential to assist clinicians and pathologists. Despite the advancements, we have stressed the importance of collaboration between medical professionals, computer scientists, bioinformaticians, and engineers to harness AI's benefits and acknowledging its limitations and risks. The integration of AI into dermatopathology holds great promise, positioning it as a valuable tool rather than as a replacement for human expertise
Side-effects and changes in systemic arterial pressure after administration of a single dose of lorazepam
No full textThe Rarity in the Rarity: Presentation of Three Cases of Cutaneous Carcinosarcoma with Clinical and Histopathological Insights
No full textfirst_page settings Order Article Reprints Open AccessCase Report The Rarity in the Rarity: Presentation of Three Cases of Cutaneous Carcinosarcoma with Clinical and Histopathological Insights by Gerardo Cazzato 1,* [ORCID] , Anna Colagrande 1 [ORCID] , Valentina Caputo 2 [ORCID] , Giuseppe Ingravallo 1 [ORCID] , Eliano Cascardi 1 [ORCID] , Francesco Fortarezza 3 [ORCID] , Emanuela Bonoldi 2 and Franco Rongioletti 4 [ORCID] 1 Section of Molecular Pathology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari “Aldo Moro”, 70124 Bari, Italy 2 U.O. Anatomia Patologica, ASST Grande Ospedale Metropolitano Niguarda, 20162 Milan, Italy 3 Surgical Pathology and Cytopathology Unit, University Hospital of Padova, 35100 Padova, Italy 4 Dermatology Clinic, Vita-Salute San Raffaele University, 20132 Milan, Italy * Author to whom correspondence should be addressed. Dermatopathology 2024, 11(3), 209-217; https://doi.org/10.3390/dermatopathology11030022 Submission received: 31 May 2024 / Revised: 10 July 2024 / Accepted: 12 July 2024 / Published: 15 July 2024 Download keyboard_arrow_down Browse Figures Review Reports Versions Notes Abstract A cutaneous carcinosarcoma (cCS) is a rare and aggressive skin cancer characterized by both carcinomatous (epithelial) and sarcomatous (mesenchymal) components, making it a biphasic tumor. Despite its occurrence in various organs, a cCS is exceptionally rare in the skin, predominantly affecting older males. The etiology of a cCS is unclear, but it may originate from a single progenitor cell capable of dual differentiation or from a collision of carcinoma and sarcoma cells. Clinically, a cCS presents as a rapidly growing, painful, ulcerated nodule or plaque on sun-exposed skin, with a high risk of local invasion and metastasis. Histopathologically, a cCS includes various epithelial components, such as squamous cell carcinoma and basal cell carcinoma, along with undifferentiated sarcomatous components resembling atypical fibroxanthoma. The tumor may also exhibit heterologous differentiation like angiosarcomatous or rhabdomyosarcomatous features. We present three cases of a cCS, highlighting their clinical and histological characteristics and comparing them with previously reported cases. Understanding a cCS is complicated by its rarity and diverse presentation, emphasizing the need for further research to elucidate its pathogenesis and optimal management
Travelling South: Charles Lister, Henry Vollan Morton, Patience Gray between Late Meridionism and Anti-Progressism
No full textThis chapter aims to examine the north-south European relationship through contemporary travel writing, especially that which depicts the Italian South. Italy and the Mediterranean have ‘always’ been the objective of Northern travellers. In the past, the European South was a sort of inner Orient, against which Northern European identity could perceive itself as a modern and, therefore superior world. Terms like “change”, “innovation”, “progress” on one hand, and “immobility”, “tradition” and “backwardness” on the other, have effortlessly been attributed to the two geo-cultural spaces. However, I would employ the term Meridionism (M. Pfister, L. Cazzato) rather than Orientalism (E. Said). If Orientalism was born as a cultural tool for the implementation of European colonialism, Meridionism was born as a cultural tool for the foundation of modern European identity.
The present essay first tries to reflect on the relationship between travel writing and cultural identity followed by an examination of some travelogues written in the second half of the 20th century by acclaimed English travel writers; specifically Charles Lister, Henry Vollan Morton and Patience Gray. I will attempt to reconstruct a multi-focalised perspective on ‘reality’, in order to observe the extent to which Meridionism is still working as a discursive tool for the negotiation of present cultural identity within Europe
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