1,721,082 research outputs found
Effetto delle proprietà chimico-fisiche sull’internalizzazione di nanovettori in cellule endoteliali
No full textA computational model for single cell Lamin-A structural organization after microfluidic compression
No full textA multi-functional scaffold for tissue regeneration: The need to engineer a tissue analogue
No full textIn designing scaffolds for tissue regeneration, the principal objective is to recapitulate extracellular matrix (ECM) function in a temporally coordinated and spatially organised structure. A key issue is to encode required biological signals within the scaffold so that all aspects of cell response-adhesion and migration, proliferation and phenotype choice-can be controlled. In achieving this objective nanotechnology, bottom-up design approach and solid free-form fabrication (SFF) will play key roles, along with self-assembly processes. For scaffold materials, there must be the correct balance between architectural features notably, porosity and chemical, physical and biological properties. This paper reviews the main achievements in biomaterials design and the future challenges
Coating process and early stage adhesion evaluation of poly(2-hydroxy-ethyl-methacrylate) hydrogel coating of 316L steel surface for stent applications
No full textIn this study, a spray-coating method has been set up with the aim to control the coating of poly(2-hydroxy-ethyl-methacrylate) (pHEMA), an hydrophilic polymeric hydrogel, onto the complex surface of a 316L steel stent for percutaneous coronary intervention (PCI). By varying process parameters, tuneable thicknesses, from 5 to 20 μm, have been obtained with uniform and homogeneous surface without crack or bridges. Surface characteristics of pHEMA coating onto metal surface have been investigated through FTIR-ATR, contact angle measurement, SEM, EDS and AFM. Moreover, results from Single-Lap-Joint and Pull-Off adhesion tests as well as calorimetric analysis of glass transition temperature suggested that pHEMA deposition is firmly adhered on metallic surface. The pHEMA coating evaluation of roughness, wettability together with its morphological and chemical stability after three cycles of expansion-crimping along with preliminary results after 6 months demonstrates the suitability of the coating for surgical implantation of sten
Determinants of cell–material crosstalk at the interface: towards engineering of cell instructive materials
No full textThe development of novel biomaterials able to control cell activities and direct their fate is
warranted for engineering functional biological tissues, advanced cell culture systems,
single-cell diagnosis as well as for cell sorting and differentiation. It is well established that
crosstalk at the cell –material interface occurs and this has a profound influence on cell behaviour. However, the complete deciphering of the cell –material communication code is still far
away. A variety of material surface properties have been reported to affect the strength and
the nature of the cell –material interactions, including biological cues, topography and mechanical properties. Novel experimental evidence bears out the hypothesis that these three
different signals participate in the same material –cytoskeleton crosstalk pathway via
adhesion plaque formation dynamics. In this review, we present the relevant findings on
material-induced cell response along with the description of cell behaviour when exposed
to arrays of signals—biochemical, topographical and mechanical. Finally, with the aid of
literature data, we attempt to draw unifying elements of the material –cytoskeleton –cell
fate chain
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