1,721,206 research outputs found
Th17 and Interleukin 23 in the Pathogenesis of Psoriatic Arthritis and Spondyloarthritis
No full textPsoriatic arthritis and spondyloarthritis (SpA) are complex immune-mediated diseases affecting peripheral and axial joints. T cells have been considered fundamental in triggering the disease and maintaining the process in the chronic phase. The recent discovery of the CD4+ Th17 lymphocyte subset and the interleukin 23/interleukin 17 axis has further contributed to the definition of unknown pathways, challenging previous models and the role of Th1/Th2 T cells in immune mediated diseases, including SpA
ENDOGENOUS AVIDIN-BINDING ACTIVITY IN EPITHELIAL-CELLS OF THE DUCTS OF HUMAN SALIVARY-GLANDS
No full textInterleukin-1, interleukin-1 receptor antagonist and macrophage populations in rheumatoid arthritis synovial membrane
No full textPsoriatic arthritis: genetics and pathogenesis
Full text linkPsoriatic arthritis is a complex disease affecting primarily peripheral and axial joints and entheses together with the skin. The pathogenesis is characterized by a genetic background and by inflammatory mechanisms which may be triggered by environmental factors. Several susceptibility genes have been investigated; they include HLA genes, genes within the HLA region and genes outside the HLA region. T cells, including the recently described subset Th17, are thought to play an important role in the acute and chronic phases of the disease. Some of these findings allowed novel therapeutic interventions or opened new promising approaches in treatment. The most relevant data of the literature are summarized and discussed
Quantification of cellular antigens by means of flow cytometry and its role in rheumatology
No full textDo B cells influence disease progression in chronic synovitis? Lessons from primary hypogammaglobulinaemia
No full textIs the geographic distribution of HLA-B27 and ankylosing spondylitis the outcome of genetic selection operated by malaria endemic? Clues for this hypothesis
No full textCYTOKINE AND ADHESION MOLECULE EXPRESSION IN THE MINOR SALIVARY-GLANDS OF PATIENTS WITH SJOGRENS-SYNDROME AND CHRONIC SIALOADENITIS
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